SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3swh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 4 VAL A1387
ALA A1318
LEU A1367
PHE A1321
 None
 1.26A 1q97B-3swhA:
undetectable		 1q97B-3swhA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 MET A1231
ASN A1210
GLN A1208
 None
 0.94A 1xoqB-3swhA:
undetectable		 1xoqB-3swhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 8 LEU A1181
LEU A1275
ASN A1271
LEU A1268
 None
 1.20A 2xn3A-3swhA:
undetectable
2xn3B-3swhA:
undetectable		 2xn3A-3swhA:
23.57
2xn3B-3swhA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 7 ARG A1174
SER A1239
ARG A1233
PHE A1234
 None
 0.99A 3ln1C-3swhA:
undetectable		 3ln1C-3swhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 VAL A1395
LEU A1367
VAL A1387
ALA A1318
SER A1320
 None
 1.09A 3rr3C-3swhA:
undetectable		 3rr3C-3swhA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 VAL A1395
LEU A1367
VAL A1387
ALA A1318
SER A1320
 None
 1.08A 3rr3D-3swhA:
undetectable		 3rr3D-3swhA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 7 LYS A1186
SER A1201
PHE A1189
ASP A1252
 None
 1.33A 4ndnC-3swhA:
undetectable		 4ndnC-3swhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 LEU A1477
ALA A1357
MET A1399
ILE A1403
GLY A1333
 None
 1.18A 5gs4A-3swhA:
undetectable		 5gs4A-3swhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 LEU A1477
ALA A1357
MET A1399
ILE A1403
GLY A1333
 None
 1.11A 5gtrA-3swhA:
undetectable		 5gtrA-3swhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 5 LEU A1268
LEU A1275
PHE A1189
LEU A1181
 None
 0.89A 5gtrA-3swhA:
1.5		 5gtrA-3swhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 11 VAL A1264
ASP A1184
LEU A1268
ASN A1270
ASN A1271
 None
 1.04A 5x6yA-3swhA:
undetectable		 5x6yA-3swhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3swh PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 11 VAL A1264
ASP A1184
LEU A1268
ASN A1270
ASN A1271
 None
 1.03A 5x6yC-3swhA:
undetectable		 5x6yC-3swhA:
19.00