SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3swl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 180
ALA A 176
LEU A 181
THR A 174
 None
 1.01A 1ictB-3swlA:
undetectable		 1ictB-3swlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 206
LEU A 181
LEU A 210
LEU A 108
LEU A 144
 None
 1.34A 1ya4B-3swlA:
undetectable		 1ya4B-3swlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 205
LEU A 144
ASP A 177
ALA A 213
ALA A 215
 None
 1.06A 2bm9F-3swlA:
undetectable		 2bm9F-3swlA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 180
ALA A 176
LEU A 181
THR A 174
 None
 1.07A 2roxB-3swlA:
undetectable		 2roxB-3swlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 180
ALA A 176
LEU A 181
THR A 174
 None
 1.06A 4i89A-3swlA:
undetectable		 4i89A-3swlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 204
ILE A 199
ASP A 141
THR A 145
 None
 0.83A 4mmcA-3swlA:
undetectable		 4mmcA-3swlA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 180
ALA A 176
LEU A 181
THR A 174
 None
 1.06A 5bojA-3swlA:
undetectable		 5bojA-3swlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		4 / 6 PRO A 224
LEU A  64
PHE A  26
LEU A  30
 None
 1.20A 5tl8A-3swlA:
undetectable		 5tl8A-3swlA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A 199
GLN A 188
VAL A 187
ILE A 110
 None
 0.68A 6cduF-3swlA:
undetectable
6cduG-3swlA:
undetectable		 6cduF-3swlA:
21.56
6cduG-3swlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens) 		4 / 8 ILE A 199
GLN A 188
VAL A 187
ILE A 110
 None
 0.55A 6cduG-3swlA:
undetectable
6cduH-3swlA:
undetectable		 6cduG-3swlA:
21.56
6cduH-3swlA:
21.56