SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3swo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 330
HIS A 313
ILE A 317
 None
 0.71A 1s9pB-3swoA:
1.4		 1s9pB-3swoA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 159
ALA A 241
ALA A 246
GLN A 189
 None
 0.79A 2nyrB-3swoA:
undetectable		 2nyrB-3swoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 246
LEU A 238
PHE A 114
SER A 110
LEU A  74
 None
 1.23A 2oipC-3swoA:
undetectable		 2oipC-3swoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A 219
LEU A 217
SER A 216
VAL A  47
 None
FDA  A 500 (-4.3A)
None
None
 0.96A 3d2tB-3swoA:
undetectable		 3d2tB-3swoA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 248
PRO A 247
LEU A 251
 EDO  A 505 (-4.9A)
None
EDO  A 505 (-4.3A)
 0.53A 3hcrA-3swoA:
undetectable		 3hcrA-3swoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLU A  59
GLU A  63
TRP A  50
 None
 1.34A 3hrdA-3swoA:
undetectable
3hrdE-3swoA:
undetectable
3hrdF-3swoA:
undetectable		 3hrdA-3swoA:
23.53
3hrdE-3swoA:
23.53
3hrdF-3swoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 137
GLY A  65
LYS A  62
VAL A 183
ASP A 136
 None
 1.07A 3m6vA-3swoA:
undetectable		 3m6vA-3swoA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 137
GLY A  65
LYS A  62
VAL A 183
ASP A 136
 None
 1.10A 3m6vB-3swoA:
undetectable		 3m6vB-3swoA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  43
LEU A  67
ARG A  42
GLY A  68
LEU A  60
 None
 1.25A 3okxB-3swoA:
undetectable		 3okxB-3swoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  53
ASP A  98
ASP A 268
 None
 0.76A 3uj7A-3swoA:
undetectable		 3uj7A-3swoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 SER A 103
GLY A 100
THR A 222
ASP A  98
 EDO  A 503 ( 4.0A)
None
FDA  A 500 ( 3.9A)
None
 1.09A 4eohA-3swoA:
undetectable		 4eohA-3swoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  53
ASP A  98
ASP A 268
 None
 0.78A 4mwzA-3swoA:
undetectable		 4mwzA-3swoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  85
ALA A 311
PHE A 256
 None
 0.71A 4olbA-3swoA:
undetectable		 4olbA-3swoA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  85
ALA A 311
PHE A 256
 None
 0.64A 4w5nA-3swoA:
undetectable		 4w5nA-3swoA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 264
LEU A 263
ASP A  21
VAL A  85
PHE A 260
 None
 1.06A 4wnwA-3swoA:
undetectable		 4wnwA-3swoA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  85
ALA A 311
PHE A 256
 None
 0.71A 4z4iA-3swoA:
undetectable		 4z4iA-3swoA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  85
ALA A 311
PHE A 256
 None
 0.70A 5js1A-3swoA:
undetectable		 5js1A-3swoA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3swo GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  56
GLU A  95
ALA A  90
GLY A  88
TYR A  87
 None
 0.89A 5uxdB-3swoA:
2.2		 5uxdB-3swoA:
22.93