SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3swt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 7 THR A 230
THR A  99
GLY A 204
ASP A 205
 None
 0.94A 1bu5A-3swtA:
undetectable		 1bu5A-3swtA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 8 THR A 230
THR A  99
GLY A 204
ASP A 205
 None
 0.92A 1bu5B-3swtA:
undetectable		 1bu5B-3swtA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 7 ASP A 280
VAL A 190
GLY A 197
THR A 130
 None
 0.83A 1t7iB-3swtA:
undetectable		 1t7iB-3swtA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 7 ASP A 280
VAL A 190
GLY A 197
THR A 130
 None
 0.82A 1t7jB-3swtA:
undetectable		 1t7jB-3swtA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 6 ARG A 251
TYR A 107
THR A 253
ALA A 252
 None
 1.44A 2ql8A-3swtA:
undetectable
2ql8B-3swtA:
undetectable		 2ql8A-3swtA:
19.37
2ql8B-3swtA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 8 LEU A 144
LEU A 141
LEU A 201
ALA A 203
 None
 0.85A 2vcvP-3swtA:
undetectable		 2vcvP-3swtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		5 / 12 LEU A 144
LEU A 148
ALA A 150
PHE A 210
THR A 130
 None
 1.11A 3gwuA-3swtA:
undetectable		 3gwuA-3swtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 5 ASN A 129
ALA A 131
ALA A 133
LYS A 142
 None
 1.40A 3kp2B-3swtA:
0.9		 3kp2B-3swtA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_E_ACTE601_0
(CHOLINE OXIDASE)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 4 TRP A 127
ILE A  45
TRP A 248
VAL A 245
 None
 1.49A 3nneE-3swtA:
0.0		 3nneE-3swtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		3 / 3 GLU A 195
ILE A 247
ALA A 252
 None
 0.37A 4wnwB-3swtA:
undetectable		 4wnwB-3swtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		5 / 11 PHE A  46
ASP A 249
TRP A 127
ILE A 247
ALA A 246
 None
 1.10A 5lg3A-3swtA:
undetectable		 5lg3A-3swtA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		5 / 12 VAL A  44
SER A  22
LEU A  23
VAL A 245
LEU A  53
 None
 1.10A 5ubbA-3swtA:
undetectable		 5ubbA-3swtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		3 / 3 GLU A 198
HIS A 193
ARG A 191
 None
 0.86A 5uunA-3swtA:
undetectable		 5uunA-3swtA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 5 HIS A  98
ASP A 100
HIS A 255
ARG A 270
 FE  A 299 (-3.3A)
FE  A 299 (-2.8A)
FE  A 299 (-3.3A)
FE  A 299 (-4.1A)
 0.84A 6dchA-3swtA:
24.4		 6dchA-3swtA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD
(Mycobacterium
marinum) 		4 / 7 GLN A 226
GLY A 204
HIS A  98
VAL A 101
 None
None
FE  A 299 (-3.3A)
None
 0.94A 6hu9S-3swtA:
undetectable
6hu9q-3swtA:
undetectable		 6hu9S-3swtA:
13.43
6hu9q-3swtA:
17.67