SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3swv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
5 / 12 LEU A 682
GLU A 676
LEU A 665
LEU A 671
GLY A 672
None
1.38A 1d4fA-3swvA:
undetectable
1d4fA-3swvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
5 / 12 LEU A 682
GLU A 676
LEU A 665
LEU A 671
GLY A 672
None
1.37A 1d4fB-3swvA:
undetectable
1d4fB-3swvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
5 / 12 LEU A 682
GLU A 676
LEU A 665
LEU A 671
GLY A 672
None
1.37A 1d4fD-3swvA:
undetectable
1d4fD-3swvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
3 / 3 ARG A 752
SER A 775
TYR A 774
None
0.69A 1x70A-3swvA:
undetectable
1x70A-3swvA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
5 / 11 ILE A 822
LEU A 730
ILE A 827
TYR A 797
THR A 781
None
1.09A 2w9sB-3swvA:
undetectable
2w9sB-3swvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
5 / 10 ILE A 822
LEU A 730
ILE A 827
TYR A 797
THR A 781
None
1.08A 2w9sD-3swvA:
undetectable
2w9sD-3swvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
5 / 10 ILE A 822
LEU A 730
ILE A 827
TYR A 797
THR A 781
None
1.10A 2w9sF-3swvA:
undetectable
2w9sF-3swvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
4 / 4 PHE A 763
THR A 761
LEU A 810
TYR A 814
None
1.44A 3pgyB-3swvA:
undetectable
3pgyB-3swvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
4 / 5 LEU A 810
ILE A 776
ALA A 769
PHE A 722
None
1.08A 4dc3B-3swvA:
undetectable
4dc3B-3swvA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
4 / 6 ALA A 679
GLN A 680
LEU A 682
LEU A 671
None
1.11A 4xoyA-3swvA:
undetectable
4xoyA-3swvA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
4 / 6 ALA A 679
GLN A 680
LEU A 682
LEU A 671
None
1.22A 4xp3A-3swvA:
undetectable
4xp3A-3swvA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo
sapiens)
4 / 4 ILE A 822
ILE A 827
ARG A 727
LEU A 783
None
1.39A 5dzkh-3swvA:
undetectable
5dzkn-3swvA:
undetectable
5dzkv-3swvA:
undetectable
5dzkh-3swvA:
21.20
5dzkn-3swvA:
21.20
5dzkv-3swvA:
0.50