SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3swx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.15A 1gtnB-3swxA:
undetectable
1gtnC-3swxA:
undetectable
1gtnB-3swxA:
14.72
1gtnC-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.11A 1gtnH-3swxA:
undetectable
1gtnI-3swxA:
undetectable
1gtnH-3swxA:
14.72
1gtnI-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 11 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.12A 1gtnM-3swxA:
undetectable
1gtnN-3swxA:
undetectable
1gtnM-3swxA:
14.72
1gtnN-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.16A 1gtnU-3swxA:
undetectable
1gtnV-3swxA:
undetectable
1gtnU-3swxA:
14.72
1gtnV-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 11 LEU A  41
ALA A 197
ALA A  53
LEU A 116
ARG A 216
None
1.38A 1iiuA-3swxA:
undetectable
1iiuA-3swxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 11 GLY A  59
PRO A  60
HIS A 189
GLY A  19
ILE A 194
None
1.18A 1jzsA-3swxA:
undetectable
1jzsA-3swxA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 12 LEU A  41
ALA A 197
ALA A  53
LEU A 116
ARG A 216
None
1.33A 1kt5A-3swxA:
undetectable
1kt5A-3swxA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.16A 1utdT-3swxA:
undetectable
1utdU-3swxA:
undetectable
1utdT-3swxA:
14.72
1utdU-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
3 / 3 ASP A  93
GLU A 115
ARG A 152
None
0.85A 1wopA-3swxA:
undetectable
1wopA-3swxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
4 / 7 MET A  33
ARG A  26
PRO A  89
GLY A 113
None
1.25A 2pnjB-3swxA:
undetectable
2pnjB-3swxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
4 / 6 ARG A 149
PHE A 150
ILE A 179
PHE A 169
None
1.25A 2qeiA-3swxA:
undetectable
2qeiA-3swxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 PHE A 169
PHE A 150
ILE A 177
GLY A 178
THR A 153
None
1.30A 3t3rD-3swxA:
undetectable
3t3rD-3swxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 12 GLY A  94
ALA A 218
GLY A 222
ASN A 214
GLN A 229
None
1.20A 3v3oA-3swxA:
undetectable
3v3oA-3swxA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
4 / 5 ILE A 179
ALA A 154
HIS A 175
ARG A 176
None
1.18A 4ac9B-3swxA:
2.6
4ac9C-3swxA:
undetectable
4ac9B-3swxA:
19.87
4ac9C-3swxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
4 / 5 ILE A 179
ALA A 154
HIS A 175
ARG A 176
None
1.20A 4acaB-3swxA:
2.1
4acaC-3swxA:
2.5
4acaB-3swxA:
19.87
4acaC-3swxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 12 ALA A  64
ASP A  30
PHE A  62
LEU A  37
LEU A  55
None
0.87A 4m2xA-3swxA:
undetectable
4m2xA-3swxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
4 / 6 ARG A  51
ILE A 200
GLN A 203
ASP A 242
None
1.04A 4w5tA-3swxA:
2.5
4w5tA-3swxA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
4 / 6 ARG A  51
ILE A 200
GLN A 203
ASP A 242
None
1.09A 4z4cA-3swxA:
undetectable
4z4cA-3swxA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.14A 5eeuF-3swxA:
undetectable
5eeuG-3swxA:
undetectable
5eeuF-3swxA:
14.72
5eeuG-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 12 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.15A 5eeuI-3swxA:
undetectable
5eeuJ-3swxA:
undetectable
5eeuI-3swxA:
14.72
5eeuJ-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.16A 5eeuO-3swxA:
undetectable
5eeuP-3swxA:
undetectable
5eeuO-3swxA:
14.72
5eeuP-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.20A 5eeuQ-3swxA:
undetectable
5eeuR-3swxA:
undetectable
5eeuQ-3swxA:
14.72
5eeuR-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.14A 5eevF-3swxA:
undetectable
5eevG-3swxA:
undetectable
5eevF-3swxA:
14.72
5eevG-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 12 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.15A 5eevI-3swxA:
undetectable
5eevJ-3swxA:
undetectable
5eevI-3swxA:
14.72
5eevJ-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.16A 5eevO-3swxA:
undetectable
5eevP-3swxA:
undetectable
5eevO-3swxA:
14.72
5eevP-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.20A 5eevQ-3swxA:
undetectable
5eevR-3swxA:
undetectable
5eevQ-3swxA:
14.72
5eevR-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.13A 5eewF-3swxA:
undetectable
5eewG-3swxA:
undetectable
5eewF-3swxA:
14.72
5eewG-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 12 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.15A 5eewI-3swxA:
undetectable
5eewJ-3swxA:
undetectable
5eewI-3swxA:
14.72
5eewJ-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.16A 5eewO-3swxA:
undetectable
5eewP-3swxA:
undetectable
5eewO-3swxA:
14.72
5eewP-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.20A 5eewQ-3swxA:
undetectable
5eewR-3swxA:
undetectable
5eewQ-3swxA:
14.72
5eewR-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.13A 5eexF-3swxA:
undetectable
5eexG-3swxA:
undetectable
5eexF-3swxA:
14.72
5eexG-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.16A 5eexO-3swxA:
undetectable
5eexP-3swxA:
undetectable
5eexO-3swxA:
14.72
5eexP-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.13A 5eeyF-3swxA:
undetectable
5eeyG-3swxA:
undetectable
5eeyF-3swxA:
14.72
5eeyG-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.16A 5eeyO-3swxA:
undetectable
5eeyP-3swxA:
undetectable
5eeyO-3swxA:
14.72
5eeyP-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.13A 5eezF-3swxA:
undetectable
5eezG-3swxA:
undetectable
5eezF-3swxA:
14.72
5eezG-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.16A 5eezO-3swxA:
undetectable
5eezP-3swxA:
undetectable
5eezO-3swxA:
14.72
5eezP-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.13A 5ef0F-3swxA:
undetectable
5ef0G-3swxA:
undetectable
5ef0F-3swxA:
14.72
5ef0G-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.15A 5ef0O-3swxA:
undetectable
5ef0P-3swxA:
undetectable
5ef0O-3swxA:
14.72
5ef0P-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.13A 5ef1F-3swxA:
undetectable
5ef1G-3swxA:
undetectable
5ef1F-3swxA:
14.72
5ef1G-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.15A 5ef1O-3swxA:
undetectable
5ef1P-3swxA:
undetectable
5ef1O-3swxA:
14.72
5ef1P-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.13A 5ef2F-3swxA:
undetectable
5ef2G-3swxA:
undetectable
5ef2F-3swxA:
14.72
5ef2G-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.15A 5ef2O-3swxA:
undetectable
5ef2P-3swxA:
undetectable
5ef2O-3swxA:
14.72
5ef2P-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 ALA A 120
GLY A 178
ALA A 117
THR A 153
ILE A 179
None
1.13A 5ef3F-3swxA:
undetectable
5ef3G-3swxA:
undetectable
5ef3F-3swxA:
14.72
5ef3G-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 10 GLY A 178
ALA A 117
THR A 153
ILE A 179
ALA A 120
None
1.15A 5ef3O-3swxA:
undetectable
5ef3P-3swxA:
undetectable
5ef3O-3swxA:
14.72
5ef3P-3swxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 12 ALA A 256
PHE A 258
GLY A 260
THR A  48
GLU A 241
None
1.37A 5hfjC-3swxA:
undetectable
5hfjC-3swxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
5 / 12 ALA A 256
PHE A 258
GLY A 260
THR A  48
GLU A 241
None
1.38A 5hfjG-3swxA:
undetectable
5hfjG-3swxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
3 / 3 VAL A  92
LEU A   7
MET A  33
None
0.86A 5ikrA-3swxA:
undetectable
5ikrA-3swxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus)
3 / 3 PHE A 258
ARG A  51
GLN A 203
None
0.85A 6g1pB-3swxA:
undetectable
6g1pB-3swxA:
23.36