SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 4 ILE A 211
MET A 233
VAL A 174
GLY A 205
 NAD  A 300 (-3.8A)
None
None
NAD  A 300 (-3.3A)
 1.42A 1e06B-3sx2A:
undetectable		 1e06B-3sx2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 4 SER A 155
ILE A 154
VAL A 206
THR A 216
 None
NAD  A 300 (-4.7A)
NAD  A 300 (-4.1A)
None
 1.17A 1u70A-3sx2A:
undetectable		 1u70A-3sx2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		7 / 11 ALA A  55
ASP A  42
LEU A  43
ASP A  80
VAL A  81
ALA A 108
VAL A 126
 NAD  A 300 (-3.3A)
NAD  A 300 (-2.9A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.5A)
NAD  A 300 (-4.1A)
 1.34A 1uayA-3sx2A:
28.6		 1uayA-3sx2A:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		8 / 11 GLY A  18
ALA A  20
ASP A  42
LEU A  43
ASP A  80
VAL A  81
ALA A 108
VAL A 126
 NAD  A 300 (-3.4A)
NAD  A 300 ( 3.9A)
NAD  A 300 (-2.9A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.5A)
NAD  A 300 (-4.1A)
 0.52A 1uayA-3sx2A:
28.6		 1uayA-3sx2A:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ALA A  55
ASP A  42
LEU A  43
ASP A  80
VAL A  81
ALA A 108
VAL A 126
 NAD  A 300 (-3.3A)
NAD  A 300 (-2.9A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.5A)
NAD  A 300 (-4.1A)
 1.39A 1uayB-3sx2A:
28.9		 1uayB-3sx2A:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		8 / 10 GLY A  18
ALA A  20
ASP A  42
LEU A  43
ASP A  80
VAL A  81
ALA A 108
VAL A 126
 NAD  A 300 (-3.4A)
NAD  A 300 ( 3.9A)
NAD  A 300 (-2.9A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.5A)
NAD  A 300 (-4.1A)
 0.57A 1uayB-3sx2A:
28.9		 1uayB-3sx2A:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 12 GLY A  18
ASP A  42
ASP A  80
ASN A 107
ALA A 108
 NAD  A 300 (-3.4A)
NAD  A 300 (-2.9A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.3A)
NAD  A 300 (-3.5A)
 0.93A 2bm9E-3sx2A:
5.0		 2bm9E-3sx2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 11 HIS A  27
ILE A  16
ALA A 252
ASN A 249
VAL A  67
 None
 1.33A 2gl0B-3sx2A:
undetectable
2gl0C-3sx2A:
undetectable		 2gl0B-3sx2A:
23.47
2gl0C-3sx2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 12 THR A 208
ASN A 127
VAL A 247
ALA A 248
VAL A 152
 NAD  A 300 (-2.8A)
NAD  A 300 ( 4.6A)
None
None
None
 1.11A 2nniA-3sx2A:
undetectable		 2nniA-3sx2A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  55
GLY A  18
ASP A  80
VAL A  81
ARG A  82
 NAD  A 300 (-3.3A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
None
 0.79A 2qe6A-3sx2A:
undetectable		 2qe6A-3sx2A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ILE A 196
ALA A 188
LEU A 153
ILE A 151
THR A 263
 None
 1.21A 2w9sD-3sx2A:
undetectable		 2w9sD-3sx2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ILE A 196
ALA A 188
LEU A 153
ILE A 151
THR A 263
 None
 1.22A 2w9sF-3sx2A:
undetectable		 2w9sF-3sx2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 12 GLY A  18
ALA A  26
ASP A  80
VAL A  81
VAL A 126
 NAD  A 300 (-3.4A)
None
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
NAD  A 300 (-4.1A)
 0.98A 3dmfA-3sx2A:
6.9		 3dmfA-3sx2A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 5 PRO A 112
THR A 134
VAL A 131
GLY A 130
 None
 1.08A 3elzA-3sx2A:
undetectable		 3elzA-3sx2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 6 PHE A  15
HIS A 133
THR A 134
VAL A 137
 None
 1.31A 3lb3A-3sx2A:
undetectable		 3lb3A-3sx2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 7 PHE A  15
ALA A 106
THR A  17
LEU A  87
 None
 0.67A 3t3sC-3sx2A:
undetectable		 3t3sC-3sx2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 7 GLY A 159
SER A 156
PHE A 273
LEU A 274
 None
NAD  A 300 ( 3.9A)
None
None
 0.89A 3v7pA-3sx2A:
3.9		 3v7pA-3sx2A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 11 GLY A 172
SER A 165
ASP A 167
VAL A 163
ASN A 127
 None
None
None
None
NAD  A 300 ( 4.6A)
 1.21A 3v8vB-3sx2A:
3.4		 3v8vB-3sx2A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 5 ILE A 103
ALA A  36
HIS A  27
ARG A  30
 None
 0.83A 4ac9B-3sx2A:
5.9
4ac9C-3sx2A:
4.5		 4ac9B-3sx2A:
20.95
4ac9C-3sx2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 5 ILE A 103
ALA A  36
HIS A  27
ARG A  30
 None
 0.86A 4acaB-3sx2A:
4.6
4acaC-3sx2A:
6.0		 4acaB-3sx2A:
20.95
4acaC-3sx2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 12 SER A  49
VAL A  50
GLN A  23
THR A 208
ASN A 127
 None
None
NAD  A 300 (-3.3A)
NAD  A 300 (-2.8A)
NAD  A 300 ( 4.6A)
 1.44A 4c49C-3sx2A:
undetectable		 4c49C-3sx2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		3 / 3 ARG A  84
HIS A 133
SER A  88
 None
 0.72A 4mjwA-3sx2A:
4.0
4mjwB-3sx2A:
3.7		 4mjwA-3sx2A:
19.78
4mjwB-3sx2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		3 / 3 SER A  88
ARG A  84
HIS A 133
 None
 0.69A 4mjwA-3sx2A:
4.0
4mjwB-3sx2A:
3.7		 4mjwA-3sx2A:
19.78
4mjwB-3sx2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 12 VAL A  81
LEU A  60
ALA A  20
THR A 134
ALA A  76
 NAD  A 300 (-3.6A)
None
NAD  A 300 ( 3.9A)
None
None
 1.22A 4x1kA-3sx2A:
6.6
4x1kB-3sx2A:
6.6		 4x1kA-3sx2A:
20.28
4x1kB-3sx2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		4 / 5 TYR A  52
GLY A 109
TYR A 173
GLY A 172
 None
NAD  A 300 (-3.5A)
NAD  A 300 (-4.6A)
None
 0.84A 5ayfA-3sx2A:
undetectable		 5ayfA-3sx2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 12 GLY A  22
GLY A  24
ALA A 248
ALA A 243
ALA A 108
 NAD  A 300 (-3.6A)
None
None
None
NAD  A 300 (-3.5A)
 1.18A 5bw4B-3sx2A:
5.3		 5bw4B-3sx2A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE
(Mycobacterium
avium) 		5 / 12 VAL A 152
ALA A 250
ILE A 211
MET A 210
ILE A 154
 None
None
NAD  A 300 (-3.8A)
NAD  A 300 (-3.7A)
NAD  A 300 (-4.7A)
 1.20A 5hbsA-3sx2A:
undetectable		 5hbsA-3sx2A:
17.44