SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		5 / 10 GLU A 386
ALA A 362
LEU A 375
GLU A 379
GLU A 382
 None
 1.34A 1a29A-3sxfA:
3.5		 1a29A-3sxfA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.41A 1k2sA-3sxfA:
undetectable
1k2sB-3sxfA:
undetectable		 1k2sA-3sxfA:
20.38
1k2sB-3sxfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.39A 1k2sA-3sxfA:
undetectable
1k2sB-3sxfA:
undetectable		 1k2sA-3sxfA:
20.38
1k2sB-3sxfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2U_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.43A 1k2uA-3sxfA:
undetectable
1k2uB-3sxfA:
undetectable		 1k2uA-3sxfA:
20.38
1k2uB-3sxfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		3 / 3 GLU A 148
LYS A 275
VAL A 277
 None
 0.75A 1l2iA-3sxfA:
undetectable		 1l2iA-3sxfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 1m00A-3sxfA:
undetectable
1m00B-3sxfA:
undetectable		 1m00A-3sxfA:
20.38
1m00B-3sxfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 ASP A 453
GLY A 456
SER A 459
THR A 461
 None
 0.88A 1m4iA-3sxfA:
undetectable		 1m4iA-3sxfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 5 GLU A 139
LEU A 180
LEU A 136
LEU A 181
 None
 1.17A 1np1A-3sxfA:
undetectable		 1np1A-3sxfA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.43A 1om5A-3sxfA:
undetectable
1om5B-3sxfA:
undetectable		 1om5A-3sxfA:
20.57
1om5B-3sxfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 1p6hA-3sxfA:
undetectable
1p6hB-3sxfA:
undetectable		 1p6hA-3sxfA:
20.57
1p6hB-3sxfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 1p6kA-3sxfA:
undetectable
1p6kB-3sxfA:
undetectable		 1p6kA-3sxfA:
20.45
1p6kB-3sxfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 5 ILE A 285
TRP A 274
LEU A 289
PRO A 249
 None
 1.24A 1s8fA-3sxfA:
undetectable
1s8fB-3sxfA:
undetectable		 1s8fA-3sxfA:
18.06
1s8fB-3sxfA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		3 / 3 ASP A 107
GLU A 183
ARG A 156
 None
 0.88A 1wopA-3sxfA:
undetectable		 1wopA-3sxfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		6 / 9 LEU A  57
VAL A  65
LYS A  80
LEU A 114
LEU A 126
LEU A 198
 BK5  A 701 ( 4.2A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.5A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
BK5  A 701 ( 4.9A)
 0.52A 1xkkA-3sxfA:
24.2		 1xkkA-3sxfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 1zzqA-3sxfA:
undetectable
1zzqB-3sxfA:
undetectable		 1zzqA-3sxfA:
20.46
1zzqB-3sxfA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 2g6hA-3sxfA:
undetectable
2g6hB-3sxfA:
undetectable		 2g6hA-3sxfA:
20.58
2g6hB-3sxfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 2g6mA-3sxfA:
undetectable
2g6mB-3sxfA:
undetectable		 2g6mA-3sxfA:
20.58
2g6mB-3sxfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 2g6mA-3sxfA:
undetectable
2g6mB-3sxfA:
undetectable		 2g6mA-3sxfA:
20.58
2g6mB-3sxfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 ASP A 368
ASP A 372
GLU A 423
SER A 425
 None
 1.12A 2q0iA-3sxfA:
undetectable		 2q0iA-3sxfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 ILE A 154
LEU A 244
LEU A 323
PHE A 146
 None
 0.90A 2vctC-3sxfA:
1.1		 2vctC-3sxfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 SER A 199
VAL A 222
TYR A 227
ASP A 174
 None
 1.11A 2x45A-3sxfA:
undetectable		 2x45A-3sxfA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 SER A 199
VAL A 222
TYR A 227
ASP A 174
 None
 1.08A 2x45B-3sxfA:
undetectable		 2x45B-3sxfA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 SER A 199
VAL A 222
TYR A 227
ASP A 174
 None
 1.11A 2x45C-3sxfA:
undetectable		 2x45C-3sxfA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 3b3mA-3sxfA:
undetectable
3b3mB-3sxfA:
undetectable		 3b3mA-3sxfA:
20.77
3b3mB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 3b3mA-3sxfA:
undetectable
3b3mB-3sxfA:
undetectable		 3b3mA-3sxfA:
20.77
3b3mB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.42A 3b3pA-3sxfA:
undetectable
3b3pB-3sxfA:
undetectable		 3b3pA-3sxfA:
20.77
3b3pB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
LEU A 198
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
BK5  A 701 ( 4.9A)
 0.89A 3bbtD-3sxfA:
23.9		 3bbtD-3sxfA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 SER A 199
VAL A 222
TYR A 227
ASP A 174
 None
 1.14A 3bu1A-3sxfA:
undetectable		 3bu1A-3sxfA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		5 / 10 VAL A 158
ALA A 299
ILE A 297
ILE A 285
ILE A 155
 None
 1.16A 3clbD-3sxfA:
undetectable		 3clbD-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		3 / 3 GLY A 265
PRO A 249
LEU A 289
 None
 0.46A 3hcpB-3sxfA:
undetectable		 3hcpB-3sxfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 3hspA-3sxfA:
undetectable
3hspB-3sxfA:
undetectable		 3hspA-3sxfA:
20.77
3hspB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		3 / 3 GLU A 183
GLY A 133
THR A 132
 None
 0.55A 3iazA-3sxfA:
undetectable		 3iazA-3sxfA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.47A 3jt3A-3sxfA:
undetectable
3jt3B-3sxfA:
undetectable		 3jt3A-3sxfA:
20.77
3jt3B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.48A 3jt4A-3sxfA:
undetectable
3jt4B-3sxfA:
undetectable		 3jt4A-3sxfA:
20.77
3jt4B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 3jt4A-3sxfA:
undetectable
3jt4B-3sxfA:
undetectable		 3jt4A-3sxfA:
20.77
3jt4B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 3jt6A-3sxfA:
undetectable
3jt6B-3sxfA:
undetectable		 3jt6A-3sxfA:
20.77
3jt6B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 3jwvA-3sxfA:
undetectable
3jwvB-3sxfA:
undetectable		 3jwvA-3sxfA:
20.77
3jwvB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 3jx0A-3sxfA:
undetectable
3jx0B-3sxfA:
undetectable		 3jx0A-3sxfA:
20.65
3jx0B-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3jx0A-3sxfA:
undetectable
3jx0B-3sxfA:
undetectable		 3jx0A-3sxfA:
20.65
3jx0B-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.48A 3jx1A-3sxfA:
undetectable
3jx1B-3sxfA:
undetectable		 3jx1A-3sxfA:
20.65
3jx1B-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 3jx4A-3sxfA:
undetectable
3jx4B-3sxfA:
undetectable		 3jx4A-3sxfA:
20.65
3jx4B-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		5 / 12 ILE A 327
GLY A 246
LEU A 323
ILE A 285
LEU A 240
 None
 1.00A 3mb5A-3sxfA:
undetectable		 3mb5A-3sxfA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 LEU A 159
ARG A 300
THR A 163
ALA A 299
 None
 1.34A 3mbgA-3sxfA:
undetectable
3mbgB-3sxfA:
undetectable		 3mbgA-3sxfA:
15.92
3mbgB-3sxfA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3n5yA-3sxfA:
0.0
3n5yB-3sxfA:
undetectable		 3n5yA-3sxfA:
20.77
3n5yB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.47A 3n5zA-3sxfA:
undetectable
3n5zB-3sxfA:
undetectable		 3n5zA-3sxfA:
20.77
3n5zB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 3nlmA-3sxfA:
undetectable
3nlmB-3sxfA:
undetectable		 3nlmA-3sxfA:
20.77
3nlmB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.47A 3nlmA-3sxfA:
undetectable
3nlmB-3sxfA:
undetectable		 3nlmA-3sxfA:
20.77
3nlmB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 3nloA-3sxfA:
undetectable
3nloB-3sxfA:
undetectable		 3nloA-3sxfA:
20.77
3nloB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3nlvA-3sxfA:
undetectable
3nlvB-3sxfA:
undetectable		 3nlvA-3sxfA:
20.77
3nlvB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 3nlwA-3sxfA:
undetectable
3nlwB-3sxfA:
undetectable		 3nlwA-3sxfA:
20.77
3nlwB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 3nlxA-3sxfA:
undetectable
3nlxB-3sxfA:
undetectable		 3nlxA-3sxfA:
20.77
3nlxB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.47A 3nlxA-3sxfA:
undetectable
3nlxB-3sxfA:
undetectable		 3nlxA-3sxfA:
20.77
3nlxB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.48A 3nlzA-3sxfA:
undetectable
3nlzB-3sxfA:
undetectable		 3nlzA-3sxfA:
20.77
3nlzB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3nlzA-3sxfA:
undetectable
3nlzB-3sxfA:
undetectable		 3nlzA-3sxfA:
20.77
3nlzB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 3nm0A-3sxfA:
undetectable
3nm0B-3sxfA:
undetectable		 3nm0A-3sxfA:
20.77
3nm0B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3nm0A-3sxfA:
undetectable
3nm0B-3sxfA:
undetectable		 3nm0A-3sxfA:
20.77
3nm0B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 3nnzA-3sxfA:
undetectable
3nnzB-3sxfA:
undetectable		 3nnzA-3sxfA:
20.77
3nnzB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.48A 3pneA-3sxfA:
undetectable
3pneB-3sxfA:
undetectable		 3pneA-3sxfA:
20.77
3pneB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3pneA-3sxfA:
undetectable
3pneB-3sxfA:
undetectable		 3pneA-3sxfA:
20.77
3pneB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 3pnfA-3sxfA:
undetectable
3pnfB-3sxfA:
undetectable		 3pnfA-3sxfA:
20.77
3pnfB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3pnfA-3sxfA:
undetectable
3pnfB-3sxfA:
undetectable		 3pnfA-3sxfA:
20.77
3pnfB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 3pngA-3sxfA:
undetectable
3pngB-3sxfA:
undetectable		 3pngA-3sxfA:
20.77
3pngB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 3rqjA-3sxfA:
undetectable
3rqjB-3sxfA:
undetectable		 3rqjA-3sxfA:
20.77
3rqjB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3rqjA-3sxfA:
undetectable
3rqjB-3sxfA:
undetectable		 3rqjA-3sxfA:
20.77
3rqjB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 3rqmA-3sxfA:
undetectable
3rqmB-3sxfA:
undetectable		 3rqmA-3sxfA:
20.77
3rqmB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3rqmA-3sxfA:
undetectable
3rqmB-3sxfA:
undetectable		 3rqmA-3sxfA:
20.77
3rqmB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3rqnA-3sxfA:
undetectable
3rqnB-3sxfA:
undetectable		 3rqnA-3sxfA:
20.77
3rqnB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 3tylA-3sxfA:
undetectable
3tylB-3sxfA:
undetectable		 3tylA-3sxfA:
20.77
3tylB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 3tyoA-3sxfA:
undetectable
3tyoB-3sxfA:
undetectable		 3tyoA-3sxfA:
20.77
3tyoB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 3ufsA-3sxfA:
undetectable
3ufsB-3sxfA:
undetectable		 3ufsA-3sxfA:
20.77
3ufsB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 3ufsA-3sxfA:
undetectable
3ufsB-3sxfA:
undetectable		 3ufsA-3sxfA:
20.77
3ufsB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 3ufuA-3sxfA:
undetectable
3ufuB-3sxfA:
undetectable		 3ufuA-3sxfA:
20.77
3ufuB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 3ufvA-3sxfA:
undetectable
3ufvB-3sxfA:
undetectable		 3ufvA-3sxfA:
20.77
3ufvB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4c39A-3sxfA:
undetectable
4c39B-3sxfA:
undetectable		 4c39A-3sxfA:
20.77
4c39B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 4caqA-3sxfA:
undetectable
4caqB-3sxfA:
undetectable		 4caqA-3sxfA:
20.77
4caqB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		6 / 11 LEU A  57
GLY A  58
GLY A  60
VAL A  65
ALA A  78
LEU A 181
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 ( 4.6A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
None
 0.65A 4ckiA-3sxfA:
22.0		 4ckiA-3sxfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4ctpA-3sxfA:
undetectable
4ctpB-3sxfA:
undetectable		 4ctpA-3sxfA:
20.77
4ctpB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4ctqA-3sxfA:
0.0
4ctqB-3sxfA:
undetectable		 4ctqA-3sxfA:
20.77
4ctqB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.47A 4ctqA-3sxfA:
undetectable
4ctqB-3sxfA:
undetectable		 4ctqA-3sxfA:
20.77
4ctqB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.49A 4cttA-3sxfA:
undetectable
4cttB-3sxfA:
undetectable		 4cttA-3sxfA:
20.77
4cttB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 4cttA-3sxfA:
undetectable
4cttB-3sxfA:
undetectable		 4cttA-3sxfA:
20.77
4cttB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.47A 4ctvA-3sxfA:
undetectable
4ctvB-3sxfA:
undetectable		 4ctvA-3sxfA:
20.77
4ctvB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 4ctwA-3sxfA:
undetectable
4ctwB-3sxfA:
undetectable		 4ctwA-3sxfA:
20.77
4ctwB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 4cx5A-3sxfA:
undetectable
4cx5B-3sxfA:
undetectable		 4cx5A-3sxfA:
20.77
4cx5B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4cx6A-3sxfA:
undetectable
4cx6B-3sxfA:
undetectable		 4cx6A-3sxfA:
20.77
4cx6B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 4cx6A-3sxfA:
undetectable
4cx6B-3sxfA:
undetectable		 4cx6A-3sxfA:
20.77
4cx6B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 4d1nC-3sxfA:
undetectable
4d1nD-3sxfA:
undetectable		 4d1nC-3sxfA:
20.19
4d1nD-3sxfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4d31A-3sxfA:
undetectable
4d31B-3sxfA:
undetectable		 4d31A-3sxfA:
20.77
4d31B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 4fvwA-3sxfA:
undetectable
4fvwB-3sxfA:
undetectable		 4fvwA-3sxfA:
20.77
4fvwB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 4fvxA-3sxfA:
undetectable
4fvxB-3sxfA:
undetectable		 4fvxA-3sxfA:
20.77
4fvxB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 4fvxA-3sxfA:
undetectable
4fvxB-3sxfA:
undetectable		 4fvxA-3sxfA:
20.77
4fvxB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 4fvyA-3sxfA:
undetectable
4fvyB-3sxfA:
undetectable		 4fvyA-3sxfA:
20.77
4fvyB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 4fvzA-3sxfA:
undetectable
4fvzB-3sxfA:
undetectable		 4fvzA-3sxfA:
20.77
4fvzB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		8 / 12 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
 0.85A 4i22A-3sxfA:
23.1		 4i22A-3sxfA:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		12 / 12 GLY A  58
VAL A  65
ALA A  78
LYS A  80
MET A 112
LEU A 114
LEU A 126
GLY A 134
GLU A 135
LEU A 181
ILE A 194
LEU A 198
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
None
None
None
BK5  A 701 ( 3.5A)
BK5  A 701 ( 4.9A)
 0.32A 4ifgA-3sxfA:
54.1		 4ifgA-3sxfA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 GLY A  58
VAL A  65
LYS A  80
LEU A 114
LEU A 126
GLU A 178
ILE A 194
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.5A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 ( 3.5A)
 1.23A 4ifgA-3sxfA:
54.1		 4ifgA-3sxfA:
99.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.42A 4imtA-3sxfA:
undetectable
4imtB-3sxfA:
undetectable		 4imtA-3sxfA:
20.77
4imtB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 4jsfA-3sxfA:
undetectable
4jsfB-3sxfA:
undetectable		 4jsfA-3sxfA:
20.77
4jsfB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 4jsgA-3sxfA:
undetectable
4jsgB-3sxfA:
undetectable		 4jsgA-3sxfA:
20.77
4jsgB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 4jshA-3sxfA:
undetectable
4jshB-3sxfA:
undetectable		 4jshA-3sxfA:
20.77
4jshB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 4jsiA-3sxfA:
undetectable
4jsiB-3sxfA:
undetectable		 4jsiA-3sxfA:
20.77
4jsiB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4jsjA-3sxfA:
undetectable
4jsjB-3sxfA:
undetectable		 4jsjA-3sxfA:
20.77
4jsjB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 4k5dA-3sxfA:
undetectable
4k5dB-3sxfA:
undetectable		 4k5dA-3sxfA:
20.77
4k5dB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 4k5fA-3sxfA:
undetectable
4k5fB-3sxfA:
undetectable		 4k5fA-3sxfA:
20.77
4k5fB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 4k5gA-3sxfA:
undetectable
4k5gB-3sxfA:
undetectable		 4k5gA-3sxfA:
20.77
4k5gB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 4k5gA-3sxfA:
undetectable
4k5gB-3sxfA:
undetectable		 4k5gA-3sxfA:
20.77
4k5gB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4kcnA-3sxfA:
undetectable
4kcnB-3sxfA:
undetectable		 4kcnA-3sxfA:
20.77
4kcnB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 4kcnA-3sxfA:
undetectable
4kcnB-3sxfA:
undetectable		 4kcnA-3sxfA:
20.77
4kcnB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 4luxA-3sxfA:
undetectable
4luxB-3sxfA:
undetectable		 4luxA-3sxfA:
20.77
4luxB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		8 / 11 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LYS A  80
ASN A 179
LEU A 181
ASP A 195
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
None
BK5  A 701 (-4.0A)
 0.93A 4o0sA-3sxfA:
26.7		 4o0sA-3sxfA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 VAL A  65
ALA A  78
LYS A  80
LEU A 181
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
 0.42A 4o0uA-3sxfA:
9.2		 4o0uA-3sxfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		5 / 6 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LEU A 181
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
None
 0.41A 4o0wA-3sxfA:
26.6		 4o0wA-3sxfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 LEU A  57
VAL A  65
ILE A 111
ILE A 193
 BK5  A 701 ( 4.2A)
BK5  A 701 (-4.2A)
None
None
 0.32A 4tyjA-3sxfA:
21.4		 4tyjA-3sxfA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 4uchA-3sxfA:
undetectable
4uchB-3sxfA:
undetectable		 4uchA-3sxfA:
20.00
4uchB-3sxfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 4ugzA-3sxfA:
undetectable
4ugzB-3sxfA:
undetectable		 4ugzA-3sxfA:
20.77
4ugzB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 4ugzA-3sxfA:
undetectable
4ugzB-3sxfA:
undetectable		 4ugzA-3sxfA:
20.77
4ugzB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 4uh0A-3sxfA:
undetectable
4uh0B-3sxfA:
undetectable		 4uh0A-3sxfA:
20.77
4uh0B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4uh2A-3sxfA:
undetectable
4uh2B-3sxfA:
undetectable		 4uh2A-3sxfA:
20.77
4uh2B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 4uh2A-3sxfA:
undetectable
4uh2B-3sxfA:
undetectable		 4uh2A-3sxfA:
20.77
4uh2B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 4uh3A-3sxfA:
undetectable
4uh3B-3sxfA:
undetectable		 4uh3A-3sxfA:
20.77
4uh3B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 4uh4A-3sxfA:
undetectable
4uh4B-3sxfA:
undetectable		 4uh4A-3sxfA:
20.77
4uh4B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4uh5A-3sxfA:
undetectable
4uh5B-3sxfA:
undetectable		 4uh5A-3sxfA:
19.81
4uh5B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 4uh6A-3sxfA:
undetectable
4uh6B-3sxfA:
undetectable		 4uh6A-3sxfA:
19.81
4uh6B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 GLU A 148
ASP A 150
ARG A 143
PRO A 321
 None
 1.22A 4uhxA-3sxfA:
undetectable		 4uhxA-3sxfA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 GLU A 148
ASP A 150
ARG A 143
PRO A 321
 None
 1.22A 4uhxA-3sxfA:
undetectable		 4uhxA-3sxfA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 4upmA-3sxfA:
undetectable
4upmB-3sxfA:
undetectable		 4upmA-3sxfA:
20.77
4upmB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 4v3uA-3sxfA:
undetectable
4v3uB-3sxfA:
undetectable		 4v3uA-3sxfA:
20.19
4v3uB-3sxfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 4v3uC-3sxfA:
undetectable
4v3uD-3sxfA:
undetectable		 4v3uC-3sxfA:
20.19
4v3uD-3sxfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 4v3yA-3sxfA:
undetectable
4v3yB-3sxfA:
undetectable		 4v3yA-3sxfA:
20.77
4v3yB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ILE A 140
PHE A 146
ARG A 143
ILE A 154
 None
 1.39A 4zzcA-3sxfA:
undetectable
4zzcB-3sxfA:
undetectable		 4zzcA-3sxfA:
19.96
4zzcB-3sxfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ILE A 140
PHE A 146
ARG A 143
ILE A 154
 None
 1.36A 4zzcB-3sxfA:
undetectable
4zzcC-3sxfA:
undetectable		 4zzcB-3sxfA:
19.96
4zzcC-3sxfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.50A 5ad4A-3sxfA:
undetectable
5ad4B-3sxfA:
undetectable		 5ad4A-3sxfA:
20.77
5ad4B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5ad4A-3sxfA:
undetectable
5ad4B-3sxfA:
undetectable		 5ad4A-3sxfA:
20.77
5ad4B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.43A 5ad5A-3sxfA:
undetectable
5ad5B-3sxfA:
undetectable		 5ad5A-3sxfA:
20.77
5ad5B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5ad5A-3sxfA:
undetectable
5ad5B-3sxfA:
undetectable		 5ad5A-3sxfA:
20.77
5ad5B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD7_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 5ad7A-3sxfA:
0.0
5ad7B-3sxfA:
0.0		 5ad7A-3sxfA:
20.77
5ad7B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5ad8A-3sxfA:
0.0
5ad8B-3sxfA:
0.0		 5ad8A-3sxfA:
20.77
5ad8B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.42A 5ad8A-3sxfA:
undetectable
5ad8B-3sxfA:
undetectable		 5ad8A-3sxfA:
20.77
5ad8B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5adaA-3sxfA:
undetectable
5adaB-3sxfA:
undetectable		 5adaA-3sxfA:
20.77
5adaB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5adaA-3sxfA:
undetectable
5adaB-3sxfA:
undetectable		 5adaA-3sxfA:
20.77
5adaB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.41A 5adbA-3sxfA:
undetectable
5adbB-3sxfA:
undetectable		 5adbA-3sxfA:
20.77
5adbB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5adcA-3sxfA:
undetectable
5adcB-3sxfA:
undetectable		 5adcA-3sxfA:
20.77
5adcB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5adcA-3sxfA:
undetectable
5adcB-3sxfA:
undetectable		 5adcA-3sxfA:
20.77
5adcB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 5addA-3sxfA:
undetectable
5addB-3sxfA:
undetectable		 5addA-3sxfA:
20.65
5addB-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 5adfA-3sxfA:
undetectable
5adfB-3sxfA:
undetectable		 5adfA-3sxfA:
19.81
5adfB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADF_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5adfA-3sxfA:
0.0
5adfB-3sxfA:
0.9		 5adfA-3sxfA:
19.81
5adfB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.43A 5adgA-3sxfA:
undetectable
5adgB-3sxfA:
undetectable		 5adgA-3sxfA:
19.81
5adgB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5adgA-3sxfA:
undetectable
5adgB-3sxfA:
undetectable		 5adgA-3sxfA:
19.81
5adgB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 5adiA-3sxfA:
undetectable
5adiB-3sxfA:
undetectable		 5adiA-3sxfA:
19.81
5adiB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5agkA-3sxfA:
undetectable
5agkB-3sxfA:
undetectable		 5agkA-3sxfA:
20.77
5agkB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5aglA-3sxfA:
undetectable
5aglB-3sxfA:
undetectable		 5aglA-3sxfA:
20.77
5aglB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5agnA-3sxfA:
undetectable
5agnB-3sxfA:
undetectable		 5agnA-3sxfA:
20.77
5agnB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5agoA-3sxfA:
undetectable
5agoB-3sxfA:
undetectable		 5agoA-3sxfA:
20.77
5agoB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5agoA-3sxfA:
undetectable
5agoB-3sxfA:
undetectable		 5agoA-3sxfA:
20.77
5agoB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5agpA-3sxfA:
undetectable
5agpB-3sxfA:
undetectable		 5agpA-3sxfA:
20.77
5agpB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.42A 5fvpA-3sxfA:
undetectable
5fvpB-3sxfA:
undetectable		 5fvpA-3sxfA:
20.77
5fvpB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5fvqA-3sxfA:
undetectable
5fvqB-3sxfA:
undetectable		 5fvqA-3sxfA:
20.77
5fvqB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 5fvrA-3sxfA:
undetectable
5fvrB-3sxfA:
undetectable		 5fvrA-3sxfA:
20.77
5fvrB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5fvrA-3sxfA:
undetectable
5fvrB-3sxfA:
undetectable		 5fvrA-3sxfA:
20.77
5fvrB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 5fvsA-3sxfA:
undetectable
5fvsB-3sxfA:
undetectable		 5fvsA-3sxfA:
20.77
5fvsB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5fvtA-3sxfA:
undetectable
5fvtB-3sxfA:
undetectable		 5fvtA-3sxfA:
20.77
5fvtB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5fvuA-3sxfA:
undetectable
5fvuB-3sxfA:
undetectable		 5fvuA-3sxfA:
19.81
5fvuB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5fvwA-3sxfA:
undetectable
5fvwB-3sxfA:
undetectable		 5fvwA-3sxfA:
19.81
5fvwB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5fvxA-3sxfA:
0.0
5fvxB-3sxfA:
0.5		 5fvxA-3sxfA:
19.81
5fvxB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 5fw0A-3sxfA:
undetectable
5fw0B-3sxfA:
undetectable		 5fw0A-3sxfA:
20.77
5fw0B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5g0nA-3sxfA:
undetectable
5g0nB-3sxfA:
undetectable		 5g0nA-3sxfA:
20.65
5g0nB-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5g0nA-3sxfA:
undetectable
5g0nB-3sxfA:
undetectable		 5g0nA-3sxfA:
20.65
5g0nB-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5g0oA-3sxfA:
undetectable
5g0oB-3sxfA:
undetectable		 5g0oA-3sxfA:
20.65
5g0oB-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.42A 5g0oA-3sxfA:
undetectable
5g0oB-3sxfA:
undetectable		 5g0oA-3sxfA:
20.65
5g0oB-3sxfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 HIS A 201
HIS A 172
ILE A 170
VAL A 171
 None
 0.99A 5kkzC-3sxfA:
undetectable
5kkzE-3sxfA:
undetectable		 5kkzC-3sxfA:
17.18
5kkzE-3sxfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 HIS A 172
ILE A 170
VAL A 171
HIS A 201
 None
 0.99A 5kkzK-3sxfA:
undetectable
5kkzQ-3sxfA:
undetectable		 5kkzK-3sxfA:
21.39
5kkzQ-3sxfA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 HIS A 201
HIS A 172
ILE A 170
VAL A 171
 None
 0.99A 5kkzM-3sxfA:
undetectable
5kkzO-3sxfA:
undetectable		 5kkzM-3sxfA:
17.18
5kkzO-3sxfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 THR A 268
CYH A 247
TYR A 241
LEU A 271
 None
 1.39A 5kxiA-3sxfA:
2.8
5kxiB-3sxfA:
2.6		 5kxiA-3sxfA:
21.38
5kxiB-3sxfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 8 THR A 268
CYH A 247
TYR A 241
LEU A 271
 None
 1.37A 5kxiD-3sxfA:
3.2
5kxiE-3sxfA:
undetectable		 5kxiD-3sxfA:
21.38
5kxiE-3sxfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 11 LEU A  57
GLY A  58
VAL A  65
ALA A  78
GLU A 135
GLU A 178
LEU A 181
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
None
None
None
 0.50A 5lvnA-3sxfA:
24.6		 5lvnA-3sxfA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 GLY A  58
VAL A  65
ALA A  78
LYS A  80
GLY A 134
GLU A 135
ILE A 194
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
None
BK5  A 701 ( 3.5A)
 0.82A 5mafA-3sxfA:
26.2		 5mafA-3sxfA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5unrA-3sxfA:
undetectable
5unrB-3sxfA:
undetectable		 5unrA-3sxfA:
20.77
5unrB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5unsA-3sxfA:
undetectable
5unsB-3sxfA:
undetectable		 5unsA-3sxfA:
20.77
5unsB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5unsA-3sxfA:
undetectable
5unsB-3sxfA:
undetectable		 5unsA-3sxfA:
20.77
5unsB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.49A 5untA-3sxfA:
undetectable
5untB-3sxfA:
undetectable		 5untA-3sxfA:
20.77
5untB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.42A 5untA-3sxfA:
undetectable
5untB-3sxfA:
undetectable		 5untA-3sxfA:
20.77
5untB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5unuA-3sxfA:
undetectable
5unuB-3sxfA:
undetectable		 5unuA-3sxfA:
20.77
5unuB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.41A 5unuA-3sxfA:
undetectable
5unuB-3sxfA:
undetectable		 5unuA-3sxfA:
20.77
5unuB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.48A 5unvA-3sxfA:
undetectable
5unvB-3sxfA:
undetectable		 5unvA-3sxfA:
20.77
5unvB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.41A 5unwA-3sxfA:
undetectable
5unwB-3sxfA:
undetectable		 5unwA-3sxfA:
20.77
5unwB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.40A 5unxA-3sxfA:
undetectable
5unxB-3sxfA:
undetectable		 5unxA-3sxfA:
20.77
5unxB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5unyA-3sxfA:
undetectable
5unyB-3sxfA:
undetectable		 5unyA-3sxfA:
20.77
5unyB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 5 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5unzA-3sxfA:
0.0
5unzB-3sxfA:
0.0		 5unzA-3sxfA:
20.77
5unzB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 5unzA-3sxfA:
undetectable
5unzB-3sxfA:
undetectable		 5unzA-3sxfA:
20.77
5unzB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5uo0A-3sxfA:
2.6
5uo0B-3sxfA:
undetectable		 5uo0A-3sxfA:
20.77
5uo0B-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5uo1A-3sxfA:
undetectable
5uo1B-3sxfA:
undetectable		 5uo1A-3sxfA:
19.81
5uo1B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5uo1A-3sxfA:
undetectable
5uo1B-3sxfA:
undetectable		 5uo1A-3sxfA:
19.81
5uo1B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 5uo2A-3sxfA:
undetectable
5uo2B-3sxfA:
undetectable		 5uo2A-3sxfA:
19.81
5uo2B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5uo3A-3sxfA:
undetectable
5uo3B-3sxfA:
undetectable		 5uo3A-3sxfA:
19.81
5uo3B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.43A 5uo4A-3sxfA:
undetectable
5uo4B-3sxfA:
undetectable		 5uo4A-3sxfA:
19.81
5uo4B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5uo4A-3sxfA:
undetectable
5uo4B-3sxfA:
undetectable		 5uo4A-3sxfA:
19.81
5uo4B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 5uo5A-3sxfA:
undetectable
5uo5B-3sxfA:
undetectable		 5uo5A-3sxfA:
19.81
5uo5B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.50A 5vujA-3sxfA:
undetectable
5vujB-3sxfA:
undetectable		 5vujA-3sxfA:
20.77
5vujB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.49A 5vukA-3sxfA:
undetectable
5vukB-3sxfA:
undetectable		 5vukA-3sxfA:
20.77
5vukB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5vukA-3sxfA:
undetectable
5vukB-3sxfA:
undetectable		 5vukA-3sxfA:
20.77
5vukB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5vulA-3sxfA:
undetectable
5vulB-3sxfA:
undetectable		 5vulA-3sxfA:
20.77
5vulB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5vulA-3sxfA:
undetectable
5vulB-3sxfA:
undetectable		 5vulA-3sxfA:
20.77
5vulB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.49A 5vumA-3sxfA:
undetectable
5vumB-3sxfA:
undetectable		 5vumA-3sxfA:
20.77
5vumB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5vumA-3sxfA:
undetectable
5vumB-3sxfA:
undetectable		 5vumA-3sxfA:
20.77
5vumB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5vunA-3sxfA:
undetectable
5vunB-3sxfA:
undetectable		 5vunA-3sxfA:
20.77
5vunB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5vunA-3sxfA:
undetectable
5vunB-3sxfA:
undetectable		 5vunA-3sxfA:
20.77
5vunB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5vuoA-3sxfA:
undetectable
5vuoB-3sxfA:
undetectable		 5vuoA-3sxfA:
20.77
5vuoB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5vuoA-3sxfA:
undetectable
5vuoB-3sxfA:
undetectable		 5vuoA-3sxfA:
20.77
5vuoB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5vupA-3sxfA:
undetectable
5vupB-3sxfA:
undetectable		 5vupA-3sxfA:
20.77
5vupB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5vupA-3sxfA:
undetectable
5vupB-3sxfA:
undetectable		 5vupA-3sxfA:
20.77
5vupB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5vuqA-3sxfA:
undetectable
5vuqB-3sxfA:
undetectable		 5vuqA-3sxfA:
20.77
5vuqB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5vuqA-3sxfA:
undetectable
5vuqB-3sxfA:
undetectable		 5vuqA-3sxfA:
20.77
5vuqB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.42A 5vurA-3sxfA:
undetectable
5vurB-3sxfA:
undetectable		 5vurA-3sxfA:
20.77
5vurB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5vusA-3sxfA:
undetectable
5vusB-3sxfA:
undetectable		 5vusA-3sxfA:
20.77
5vusB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5vusA-3sxfA:
undetectable
5vusB-3sxfA:
undetectable		 5vusA-3sxfA:
20.77
5vusB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 5vutA-3sxfA:
undetectable
5vutB-3sxfA:
undetectable		 5vutA-3sxfA:
20.77
5vutB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5vutA-3sxfA:
undetectable
5vutB-3sxfA:
undetectable		 5vutA-3sxfA:
20.77
5vutB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.47A 5vuuA-3sxfA:
undetectable
5vuuB-3sxfA:
undetectable		 5vuuA-3sxfA:
20.77
5vuuB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5vuuA-3sxfA:
undetectable
5vuuB-3sxfA:
undetectable		 5vuuA-3sxfA:
20.77
5vuuB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.42A 5vuvA-3sxfA:
undetectable
5vuvB-3sxfA:
undetectable		 5vuvA-3sxfA:
19.81
5vuvB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5vuvA-3sxfA:
undetectable
5vuvB-3sxfA:
undetectable		 5vuvA-3sxfA:
19.81
5vuvB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 5vuwA-3sxfA:
undetectable
5vuwB-3sxfA:
undetectable		 5vuwA-3sxfA:
19.81
5vuwB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 5vuwA-3sxfA:
undetectable
5vuwB-3sxfA:
undetectable		 5vuwA-3sxfA:
19.81
5vuwB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 5vuxA-3sxfA:
undetectable
5vuxB-3sxfA:
undetectable		 5vuxA-3sxfA:
19.81
5vuxB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.42A 5vuxA-3sxfA:
0.0
5vuxB-3sxfA:
0.0		 5vuxA-3sxfA:
19.81
5vuxB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.38A 5vuyA-3sxfA:
undetectable
5vuyB-3sxfA:
undetectable		 5vuyA-3sxfA:
19.81
5vuyB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5vuzA-3sxfA:
undetectable
5vuzB-3sxfA:
undetectable		 5vuzA-3sxfA:
19.81
5vuzB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5vuzA-3sxfA:
undetectable
5vuzB-3sxfA:
undetectable		 5vuzA-3sxfA:
19.81
5vuzB-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5vv0A-3sxfA:
undetectable
5vv0B-3sxfA:
1.0		 5vv0A-3sxfA:
19.81
5vv0B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.45A 5vv0A-3sxfA:
undetectable
5vv0B-3sxfA:
1.0		 5vv0A-3sxfA:
19.81
5vv0B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 5vv1A-3sxfA:
undetectable
5vv1B-3sxfA:
undetectable		 5vv1A-3sxfA:
19.81
5vv1B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 5vv1A-3sxfA:
undetectable
5vv1B-3sxfA:
undetectable		 5vv1A-3sxfA:
19.81
5vv1B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5vv2A-3sxfA:
undetectable
5vv2B-3sxfA:
undetectable		 5vv2A-3sxfA:
19.81
5vv2B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.46A 5vv2A-3sxfA:
undetectable
5vv2B-3sxfA:
undetectable		 5vv2A-3sxfA:
19.81
5vv2B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 5vv3A-3sxfA:
undetectable
5vv3B-3sxfA:
undetectable		 5vv3A-3sxfA:
19.81
5vv3B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 5vv4A-3sxfA:
0.0
5vv4B-3sxfA:
0.9		 5vv4A-3sxfA:
19.81
5vv4B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		8 / 12 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
 0.81A 5yu9A-3sxfA:
23.3		 5yu9A-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 GLY A  58
VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
 0.70A 5yu9B-3sxfA:
23.6		 5yu9B-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		5 / 12 VAL A  65
ALA A  78
LYS A  80
LEU A 126
ASP A 195
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
BK5  A 701 (-4.0A)
 0.39A 5yu9C-3sxfA:
23.6		 5yu9C-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		6 / 12 VAL A  65
ALA A  78
LYS A  80
LEU A 181
ASP A 195
LEU A 198
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
BK5  A 701 (-4.0A)
BK5  A 701 ( 4.9A)
 0.63A 5yu9D-3sxfA:
23.8		 5yu9D-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 6auqA-3sxfA:
undetectable
6auqB-3sxfA:
undetectable		 6auqA-3sxfA:
9.13
6auqB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 6aurA-3sxfA:
undetectable
6aurB-3sxfA:
undetectable		 6aurA-3sxfA:
9.13
6aurB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 6aurA-3sxfA:
undetectable
6aurB-3sxfA:
undetectable		 6aurA-3sxfA:
9.13
6aurB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 6ausA-3sxfA:
undetectable
6ausB-3sxfA:
undetectable		 6ausA-3sxfA:
9.13
6ausB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 6ausA-3sxfA:
undetectable
6ausB-3sxfA:
undetectable		 6ausA-3sxfA:
9.13
6ausB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 6autA-3sxfA:
undetectable
6autB-3sxfA:
undetectable		 6autA-3sxfA:
9.13
6autB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 6auuA-3sxfA:
undetectable
6auuB-3sxfA:
undetectable		 6auuA-3sxfA:
9.13
6auuB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 6auuA-3sxfA:
undetectable
6auuB-3sxfA:
undetectable		 6auuA-3sxfA:
9.13
6auuB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 6auvA-3sxfA:
undetectable
6auvB-3sxfA:
undetectable		 6auvA-3sxfA:
9.13
6auvB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.48A 6auwA-3sxfA:
undetectable
6auwB-3sxfA:
undetectable		 6auwA-3sxfA:
9.13
6auwB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 6auwA-3sxfA:
undetectable
6auwB-3sxfA:
undetectable		 6auwA-3sxfA:
9.13
6auwB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 6auxA-3sxfA:
undetectable
6auxB-3sxfA:
undetectable		 6auxA-3sxfA:
9.13
6auxB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 6auxA-3sxfA:
undetectable
6auxB-3sxfA:
undetectable		 6auxA-3sxfA:
9.13
6auxB-3sxfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 6auyA-3sxfA:
undetectable
6auyB-3sxfA:
undetectable		 6auyA-3sxfA:
10.19
6auyB-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 6auzA-3sxfA:
undetectable
6auzB-3sxfA:
undetectable		 6auzA-3sxfA:
10.19
6auzB-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.46A 6av0A-3sxfA:
undetectable
6av0B-3sxfA:
undetectable		 6av0A-3sxfA:
10.19
6av0B-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.42A 6av1A-3sxfA:
undetectable
6av1B-3sxfA:
undetectable		 6av1A-3sxfA:
10.19
6av1B-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 6av4A-3sxfA:
undetectable
6av4B-3sxfA:
undetectable		 6av4A-3sxfA:
10.19
6av4B-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 6av5A-3sxfA:
undetectable
6av5B-3sxfA:
undetectable		 6av5A-3sxfA:
10.19
6av5B-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		3 / 3 ARG A 145
LYS A 144
ARG A 445
 None
 1.29A 6c06D-3sxfA:
undetectable		 6c06D-3sxfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ILE A 154
GLN A 157
VAL A 158
ILE A 239
 None
 0.90A 6cduF-3sxfA:
undetectable
6cduG-3sxfA:
undetectable		 6cduF-3sxfA:
21.10
6cduG-3sxfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.45A 6cicA-3sxfA:
undetectable
6cicB-3sxfA:
undetectable		 6cicA-3sxfA:
10.19
6cicB-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.43A 6cicA-3sxfA:
undetectable
6cicB-3sxfA:
undetectable		 6cicA-3sxfA:
10.19
6cicB-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.44A 6cidA-3sxfA:
undetectable
6cidB-3sxfA:
1.0		 6cidA-3sxfA:
10.19
6cidB-3sxfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 7 TRP A 274
PHE A 269
ARG A 286
VAL A 277
 None
DMS  A 711 (-3.9A)
DMS  A 711 (-4.1A)
None
 1.44A 6cidA-3sxfA:
undetectable
6cidB-3sxfA:
1.0		 6cidA-3sxfA:
10.19
6cidB-3sxfA:
10.19