SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.24A 1hrkB-3sxmA:
undetectable		 1hrkB-3sxmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.33A 2pnjB-3sxmA:
undetectable		 2pnjB-3sxmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.22A 2po7B-3sxmA:
undetectable		 2po7B-3sxmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 11 LEU A  94
LEU A 193
LEU A 197
ILE A 101
TRP A 154
 None
 1.28A 2qd3A-3sxmA:
undetectable		 2qd3A-3sxmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.28A 3aqiB-3sxmA:
undetectable		 3aqiB-3sxmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.24A 3w1wA-3sxmA:
undetectable		 3w1wA-3sxmA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.24A 3w1wB-3sxmA:
undetectable		 3w1wB-3sxmA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		4 / 8 GLU A 191
GLU A 179
GLY A 184
SER A 183
 None
 0.92A 4f93B-3sxmA:
undetectable		 4f93B-3sxmA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY
(Thermotoga
maritima) 		5 / 12 LEU A 193
GLU A  90
ARG A  86
ILE A 114
LEU A 107
 None
 1.23A 4j26B-3sxmA:
undetectable		 4j26B-3sxmA:
19.42