SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		4 / 7 TYR A 186
GLU A 296
SER A 256
VAL A 230
 NAD  A2402 (-4.4A)
None
None
None
 1.05A 1tv8B-3sxpA:
2.5		 1tv8B-3sxpA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		6 / 11 GLY A  17
ALA A  19
ASP A  43
ASP A  76
ALA A  98
VAL A 100
 NAD  A2402 (-3.4A)
NAD  A2402 (-4.1A)
NAD  A2402 (-2.6A)
NAD  A2402 (-3.4A)
NAD  A2402 (-3.5A)
None
 0.51A 1uayA-3sxpA:
16.6		 1uayA-3sxpA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		6 / 10 GLY A  17
ALA A  19
ASP A  43
ASP A  76
ALA A  98
VAL A 100
 NAD  A2402 (-3.4A)
NAD  A2402 (-4.1A)
NAD  A2402 (-2.6A)
NAD  A2402 (-3.4A)
NAD  A2402 (-3.5A)
None
 0.55A 1uayB-3sxpA:
16.8		 1uayB-3sxpA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		3 / 3 SER A 128
HIS A  96
ASP A  43
 None
None
NAD  A2402 (-2.6A)
 0.78A 2oxtA-3sxpA:
5.0		 2oxtA-3sxpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		4 / 4 ARG A 227
ASP A 169
GLY A 152
THR A 145
 None
 1.14A 3k4vB-3sxpA:
undetectable		 3k4vB-3sxpA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		5 / 12 GLY A 140
GLY A 143
ASN A 144
LEU A 166
PHE A 163
 None
 0.85A 3p2kC-3sxpA:
5.3		 3p2kC-3sxpA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		4 / 8 VAL A 253
TYR A 255
LEU A 307
TYR A   3
 None
 1.07A 3v81A-3sxpA:
undetectable		 3v81A-3sxpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		4 / 5 PHE A 229
GLY A 223
ILE A 264
VAL A 265
 None
 0.88A 3wrkA-3sxpA:
undetectable		 3wrkA-3sxpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		4 / 8 SER A 312
GLU A 311
GLN A 257
ILE A 295
 None
 0.86A 4dx7B-3sxpA:
undetectable		 4dx7B-3sxpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		3 / 3 PRO A 306
TYR A 255
GLY A 254
 None
 0.73A 4g2zA-3sxpA:
undetectable		 4g2zA-3sxpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		3 / 3 ASP A 102
LEU A  59
VAL A  22
 None
NAD  A2402 ( 4.4A)
NAD  A2402 (-3.8A)
 0.66A 4jecB-3sxpA:
undetectable		 4jecB-3sxpA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		4 / 5 GLN A 117
THR A  16
LEU A  86
LEU A  83
 None
 1.09A 4lvcB-3sxpA:
5.4		 4lvcB-3sxpA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		4 / 5 GLN A 117
THR A 114
LEU A  86
LEU A  83
 None
NAD  A2402 ( 4.9A)
None
None
 0.96A 4lvcB-3sxpA:
5.4		 4lvcB-3sxpA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		5 / 12 GLY A 254
THR A 298
ILE A 232
GLU A 194
LEU A 184
 None
 1.12A 5bw4A-3sxpA:
5.4		 5bw4A-3sxpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		3 / 3 ALA A 118
ASN A 121
LEU A 122
 None
 0.35A 5i1nB-3sxpA:
undetectable		 5i1nB-3sxpA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		3 / 3 ALA A 118
ASN A 121
LEU A 122
 None
 0.42A 5i1oA-3sxpA:
undetectable		 5i1oA-3sxpA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		3 / 3 ALA A 118
ASN A 121
LEU A 122
 None
 0.39A 5i1pA-3sxpA:
undetectable		 5i1pA-3sxpA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		3 / 3 ALA A 118
ASN A 121
LEU A 122
 None
 0.46A 5i1pD-3sxpA:
undetectable		 5i1pD-3sxpA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		3 / 3 SER A 138
ALA A 139
THR A 291
 NAD  A2402 (-3.3A)
None
None
 0.41A 5n0xB-3sxpA:
undetectable		 5n0xB-3sxpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE
(Helicobacter
pylori) 		5 / 10 VAL A 182
GLY A 249
ALA A 242
LEU A 184
ASN A 252
 None
 1.02A 5x6yB-3sxpA:
2.5		 5x6yB-3sxpA:
18.81