SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sy6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		5 / 11 LEU A 116
ASN A  69
TYR A 131
GLY A  55
TYR A 107
 None
 1.40A 1fkpA-3sy6A:
undetectable		 1fkpA-3sy6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		4 / 8 LEU A 116
TYR A 131
GLY A  55
TYR A 107
 None
 0.83A 1jlfA-3sy6A:
undetectable
1jlfB-3sy6A:
undetectable		 1jlfA-3sy6A:
20.00
1jlfB-3sy6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		4 / 7 LEU A 116
TYR A 131
GLY A  55
TYR A 107
 None
 0.90A 1lweA-3sy6A:
undetectable		 1lweA-3sy6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		4 / 7 PHE A 184
TYR A 233
VAL A 249
ILE A 247
 None
 0.99A 1p7rA-3sy6A:
undetectable		 1p7rA-3sy6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		4 / 8 CYH A 130
TYR A 107
ARG A  44
TYR A  97
 None
 1.38A 1xqlA-3sy6A:
undetectable
1xqlB-3sy6A:
undetectable		 1xqlA-3sy6A:
22.25
1xqlB-3sy6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		5 / 12 PHE A 184
ALA A 289
ILE A 247
ILE A 182
THR A 164
 None
 1.30A 2bjfA-3sy6A:
undetectable		 2bjfA-3sy6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		5 / 12 PHE A  94
PHE A  57
THR A  59
ALA A  92
ILE A 199
 None
 1.18A 2rlcA-3sy6A:
undetectable		 2rlcA-3sy6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		5 / 10 LEU A 116
ASN A  69
TYR A 131
GLY A  55
TYR A 107
 None
 1.43A 3lp1A-3sy6A:
undetectable		 3lp1A-3sy6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		5 / 11 VAL A 142
ALA A 136
GLY A 139
ASN A 146
PHE A 148
 None
 1.37A 3qxyB-3sy6A:
undetectable
3qxyQ-3sy6A:
undetectable		 3qxyB-3sy6A:
20.09
3qxyQ-3sy6A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		4 / 4 ASP A  82
ASP A  83
GLY A  80
THR A  29
 None
 1.08A 3tl9B-3sy6A:
undetectable		 3tl9B-3sy6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 3sy6 FIMBRIAL PROTEIN
BF1861
(Bacteroides
fragilis) 		4 / 8 ASN A 124
GLU A 232
PHE A 123
TYR A 215
 None
 1.32A 5oh1C-3sy6A:
undetectable		 5oh1C-3sy6A:
16.96