SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sy8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 146
PHE A 193
ASN A 153
 None
 0.80A 1sg9B-3sy8A:
undetectable		 1sg9B-3sy8A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 391
PRO A 162
ALA A 174
ILE A 228
 None
 0.80A 2aofA-3sy8A:
undetectable		 2aofA-3sy8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 106
LEU A 122
LEU A 121
ILE A 118
ILE A  52
 None
 1.19A 2f78A-3sy8A:
undetectable		 2f78A-3sy8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 106
LEU A 122
LEU A 121
ILE A 118
ILE A  52
 None
 1.19A 2f78B-3sy8A:
undetectable		 2f78B-3sy8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 106
LEU A 122
LEU A 121
ILE A 118
ILE A  52
 None
 1.16A 2f7aA-3sy8A:
undetectable		 2f7aA-3sy8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 154
GLN A 209
LEU A 206
PHE A 156
MET A 197
 None
 1.41A 3h52C-3sy8A:
undetectable		 3h52C-3sy8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 251
ASN A 247
TRP A 208
SER A 212
 None
 1.19A 3i9jB-3sy8A:
4.6		 3i9jB-3sy8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 366
PHE A 321
ILE A 335
CYH A 368
SER A 356
 None
 1.35A 3m0wE-3sy8A:
undetectable
3m0wF-3sy8A:
undetectable
3m0wG-3sy8A:
undetectable
3m0wH-3sy8A:
undetectable		 3m0wE-3sy8A:
15.66
3m0wF-3sy8A:
15.66
3m0wG-3sy8A:
15.66
3m0wH-3sy8A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 366
PHE A 321
ILE A 335
CYH A 368
SER A 356
 None
 1.38A 3m0wA-3sy8A:
undetectable
3m0wB-3sy8A:
undetectable
3m0wI-3sy8A:
undetectable
3m0wJ-3sy8A:
undetectable		 3m0wA-3sy8A:
15.66
3m0wB-3sy8A:
15.66
3m0wI-3sy8A:
15.66
3m0wJ-3sy8A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 266
ALA A 293
ILE A 248
LEU A 244
VAL A 234
 None
 1.05A 3n0hA-3sy8A:
undetectable		 3n0hA-3sy8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 264
GLN A 314
PHE A 211
 None
 0.79A 3rv5A-3sy8A:
undetectable		 3rv5A-3sy8A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 266
ALA A 293
ILE A 248
LEU A 244
VAL A 234
 None
 1.01A 3s3vA-3sy8A:
undetectable		 3s3vA-3sy8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 326
SER A 356
GLN A 359
 None
 1.12A 3si7A-3sy8A:
undetectable		 3si7A-3sy8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 9 PHE A 264
LEU A 252
THR A 253
LEU A 285
ILE A 248
 None
 1.19A 3tbgD-3sy8A:
undetectable		 3tbgD-3sy8A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 7 GLY A  75
SER A  74
SER A  72
PHE A  67
LEU A  44
 None
 1.17A 3v7pA-3sy8A:
3.0		 3v7pA-3sy8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		4 / 8 VAL A   8
ILE A  54
CYH A  55
ASP A  56
 None
 0.66A 3wzeA-3sy8A:
undetectable		 3wzeA-3sy8A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 233
SER A 241
LEU A 244
THR A 267
 MG  A 401 (-2.7A)
None
None
None
 1.31A 4an2A-3sy8A:
undetectable		 4an2A-3sy8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 266
ALA A 293
ILE A 248
LEU A 244
VAL A 234
 None
 1.07A 4kfjB-3sy8A:
undetectable		 4kfjB-3sy8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 291
ALA A 293
PHE A 264
GLU A 265
 None
None
None
MG  A 401 (-3.4A)
 0.85A 4m93B-3sy8A:
undetectable
4m93C-3sy8A:
undetectable		 4m93B-3sy8A:
21.26
4m93C-3sy8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  34
LEU A  65
ILE A  98
THR A  94
LEU A  82
 None
 1.22A 4n48B-3sy8A:
undetectable		 4n48B-3sy8A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3sy8 ROCR
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  65
LEU A  68
ILE A  98
MET A  97
 None
 0.93A 4ww7A-3sy8A:
undetectable		 4ww7A-3sy8A:
20.60