SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3syj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 10 ALA A 622
GLU A 110
LEU A 203
ARG A  81
ILE A 236
None
1.34A 1a52B-3syjA:
undetectable
1a52B-3syjA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 9 GLU A 473
SER A 450
VAL A 451
GLY A 499
GLY A 502
None
1.31A 1bcuH-3syjA:
15.6
1bcuH-3syjA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 GLY A 569
LEU A 601
LEU A 582
VAL A 537
LEU A 507
None
1.04A 1gseB-3syjA:
undetectable
1gseB-3syjA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 10 THR A 208
GLY A 206
LEU A 263
PHE A 276
GLY A 180
None
1.48A 1h4oA-3syjA:
undetectable
1h4oB-3syjA:
undetectable
1h4oA-3syjA:
11.87
1h4oB-3syjA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 ASN A  99
ILE A  93
SER A  80
ASN A  82
None
1.22A 1h7xA-3syjA:
undetectable
1h7xA-3syjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 ASN A  99
ILE A  93
SER A  80
ASN A  82
None
1.22A 1h7xB-3syjA:
undetectable
1h7xB-3syjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 ASN A  99
ILE A  93
SER A  80
ASN A  82
None
1.22A 1h7xC-3syjA:
undetectable
1h7xC-3syjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 ASN A  99
ILE A  93
SER A  80
ASN A  82
None
1.21A 1h7xD-3syjA:
undetectable
1h7xD-3syjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 THR A 159
SER A 160
TYR A 231
LEU A 221
None
1.00A 1ibgL-3syjA:
undetectable
1ibgL-3syjA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 5 PHE A 657
GLY A 675
SER A 672
THR A 651
None
1.33A 1icuC-3syjA:
undetectable
1icuD-3syjA:
undetectable
1icuC-3syjA:
12.56
1icuD-3syjA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 HIS A 345
ASP A 139
ASP A 140
PRO A 347
None
1.25A 1ilqA-3syjA:
undetectable
1ilqC-3syjA:
undetectable
1ilqA-3syjA:
4.85
1ilqC-3syjA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 10 ALA A 622
GLU A 110
LEU A 203
ARG A  81
ILE A 236
None
1.31A 1pcgA-3syjA:
undetectable
1pcgA-3syjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 GLN A 211
LEU A 221
ILE A 262
GLY A 261
VAL A  94
None
1.01A 1vptA-3syjA:
undetectable
1vptA-3syjA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 TRP A 257
THR A 208
TYR A 231
None
1.25A 2a3aB-3syjA:
undetectable
2a3aB-3syjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 GLY A 241
TYR A 200
SER A 243
HIS A  98
None
1.11A 2ackA-3syjA:
undetectable
2ackA-3syjA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 GLY A  26
GLY A 180
ARG A 187
HIS A  27
ILE A  32
None
1.12A 2b25B-3syjA:
undetectable
2b25B-3syjA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 THR A 699
SER A 615
SER A 667
VAL A 665
None
1.05A 2hdnE-3syjA:
undetectable
2hdnF-3syjA:
undetectable
2hdnH-3syjA:
undetectable
2hdnE-3syjA:
3.57
2hdnF-3syjA:
15.04
2hdnH-3syjA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 SER A 667
VAL A 665
THR A 699
SER A 615
None
1.06A 2hdnF-3syjA:
undetectable
2hdnG-3syjA:
undetectable
2hdnH-3syjA:
undetectable
2hdnF-3syjA:
15.04
2hdnG-3syjA:
3.57
2hdnH-3syjA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 THR A 699
SER A 615
SER A 667
VAL A 665
None
1.07A 2hdnI-3syjA:
undetectable
2hdnJ-3syjA:
undetectable
2hdnL-3syjA:
undetectable
2hdnI-3syjA:
3.57
2hdnJ-3syjA:
15.04
2hdnL-3syjA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 SER A 667
VAL A 665
THR A 699
SER A 615
None
1.07A 2hdnJ-3syjA:
undetectable
2hdnK-3syjA:
undetectable
2hdnL-3syjA:
undetectable
2hdnJ-3syjA:
15.04
2hdnK-3syjA:
3.57
2hdnL-3syjA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 SER A 379
ILE A 381
SER A 308
LEU A 331
ASN A 333
None
1.05A 2nnhA-3syjA:
undetectable
2nnhA-3syjA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 THR A 921
ASP A 902
ASN A 876
ASP A 830
None
1.32A 2okcA-3syjA:
undetectable
2okcA-3syjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 9 VAL A  96
GLY A 180
ILE A 179
VAL A  94
ILE A 262
None
1.08A 2q5kA-3syjA:
undetectable
2q5kA-3syjA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 PRO A 724
ASN A 669
ARG A 668
None
0.67A 2qeuB-3syjA:
undetectable
2qeuB-3syjA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 8 PHE A 491
TYR A 564
LEU A 507
LEU A 485
None
0.90A 2w98B-3syjA:
undetectable
2w98B-3syjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 THR A 159
MET A 247
PHE A 276
ILE A 262
None
1.30A 2w98B-3syjA:
undetectable
2w98B-3syjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 11 PHE A 496
ILE A 526
PHE A 514
PHE A 498
VAL A 451
None
1.08A 3a9eB-3syjA:
undetectable
3a9eB-3syjA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 PHE A 185
ARG A 178
ASN A 274
GLY A 222
LEU A 263
None
1.38A 3aobC-3syjA:
undetectable
3aobC-3syjA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 LYS A 725
HIS A 645
LYS A 718
ILE A 720
None
1.16A 3eteD-3syjA:
undetectable
3eteF-3syjA:
undetectable
3eteD-3syjA:
20.65
3eteF-3syjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 PRO A 144
SER A  95
ASN A 128
None
0.78A 3lslG-3syjA:
undetectable
3lslG-3syjA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 8 SER A 243
VAL A  84
ARG A 126
VAL A  96
None
0.91A 3nlrA-3syjA:
undetectable
3nlrB-3syjA:
undetectable
3nlrA-3syjA:
17.74
3nlrB-3syjA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 8 GLU A 152
TYR A 121
LEU A 146
PHE A 107
None
1.00A 3rqwC-3syjA:
undetectable
3rqwD-3syjA:
undetectable
3rqwC-3syjA:
15.38
3rqwD-3syjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 8 GLU A 152
TYR A 121
LEU A 146
PHE A 107
None
1.00A 3rqwI-3syjA:
undetectable
3rqwJ-3syjA:
undetectable
3rqwI-3syjA:
15.38
3rqwJ-3syjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 8 GLU A 152
TYR A 121
LEU A 146
PHE A 107
None
1.01A 3rqwF-3syjA:
undetectable
3rqwJ-3syjA:
undetectable
3rqwF-3syjA:
15.38
3rqwJ-3syjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 5 LEU A 476
GLY A 503
PHE A 498
PHE A 496
None
1.01A 3smtA-3syjA:
undetectable
3smtA-3syjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 VAL A  96
HIS A  98
ASP A 140
GLY A 241
SER A 243
None
0.90A 3sufB-3syjA:
6.8
3sufB-3syjA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 10 PHE A 284
LEU A 146
VAL A 105
PHE A 107
VAL A 150
None
1.49A 3u9fE-3syjA:
undetectable
3u9fE-3syjA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 TYR A 231
GLU A 273
TYR A 220
None
0.93A 3ug8A-3syjA:
undetectable
3ug8A-3syjA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 GLN A  52
THR A  66
ASN A  53
None
0.82A 3v4tE-3syjA:
undetectable
3v4tE-3syjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 SER A 663
GLY A 662
GLN A 607
None
0.43A 3v4tH-3syjA:
undetectable
3v4tH-3syjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 THR A 817
ARG A 773
ILE A 810
LEU A 836
None
1.07A 4acbC-3syjA:
undetectable
4acbC-3syjA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 11 THR A 151
LEU A  87
PHE A 107
SER A 430
VAL A 124
None
1.46A 4claA-3syjA:
undetectable
4claA-3syjA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 ASN A  90
LEU A  87
GLY A 452
SER A 478
None
0.98A 4cp3A-3syjA:
undetectable
4cp3B-3syjA:
undetectable
4cp3A-3syjA:
7.87
4cp3B-3syjA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 VAL A 105
TYR A 102
PRO A 144
ILE A 179
ILE A 156
None
1.42A 4eb6B-3syjA:
undetectable
4eb6C-3syjA:
undetectable
4eb6B-3syjA:
18.97
4eb6C-3syjA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 PHE A 614
VAL A 670
GLY A 598
PHE A 657
None
1.00A 4ejjB-3syjA:
undetectable
4ejjB-3syjA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 8 ASN A 542
GLY A 541
ILE A 517
PHE A 568
None
0.90A 4fglD-3syjA:
undetectable
4fglD-3syjA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 ASN A 542
GLY A 541
ILE A 517
PHE A 568
None
0.81A 4fglC-3syjA:
undetectable
4fglC-3syjA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 5 HIS A  98
TYR A 200
GLY A 241
SER A 243
None
1.16A 4fu8A-3syjA:
5.3
4fu8A-3syjA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 8 LEU A 595
TYR A 564
LEU A 580
LEU A 601
None
0.91A 4l1xA-3syjA:
undetectable
4l1xA-3syjA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 GLU A 152
TYR A 121
LEU A 146
PHE A 107
None
0.95A 4twdB-3syjA:
undetectable
4twdC-3syjA:
undetectable
4twdB-3syjA:
14.96
4twdC-3syjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 GLU A 152
TYR A 121
LEU A 146
PHE A 107
None
0.91A 4twdD-3syjA:
undetectable
4twdE-3syjA:
undetectable
4twdD-3syjA:
14.96
4twdE-3syjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 GLU A 152
TYR A 121
LEU A 146
PHE A 107
None
0.97A 4twdF-3syjA:
undetectable
4twdJ-3syjA:
undetectable
4twdF-3syjA:
14.96
4twdJ-3syjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 GLU A 152
TYR A 121
LEU A 146
PHE A 107
None
0.99A 4twdF-3syjA:
undetectable
4twdG-3syjA:
undetectable
4twdF-3syjA:
14.96
4twdG-3syjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 ASN A  90
GLU A 152
TYR A 121
LEU A 146
None
1.25A 4twdI-3syjA:
undetectable
4twdJ-3syjA:
undetectable
4twdI-3syjA:
14.96
4twdJ-3syjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 6 GLU A 152
TYR A 121
LEU A 146
PHE A 107
None
1.01A 4twdI-3syjA:
undetectable
4twdJ-3syjA:
undetectable
4twdI-3syjA:
14.96
4twdJ-3syjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 ARG A 118
THR A 704
TRP A 703
None
1.14A 4ug5A-3syjA:
undetectable
4ug5A-3syjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 GLY A  83
TYR A 167
GLY A 215
GLY A 217
PHE A 248
None
1.11A 5eqbA-3syjA:
undetectable
5eqbA-3syjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 ASP A 487
ASN A 530
GLN A 533
None
0.78A 5k7uA-3syjA:
undetectable
5k7uA-3syjA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 VAL A 424
ASP A 427
PHE A 377
GLY A 408
LEU A 388
None
1.19A 5m54E-3syjA:
undetectable
5m54E-3syjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 VAL A 105
ASP A 104
ALA A  85
SER A  80
GLY A 101
None
1.20A 5m5cB-3syjA:
undetectable
5m5cB-3syjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 LYS A 420
TRP A 419
SER A 397
None
1.34A 5nwwA-3syjA:
undetectable
5nwwA-3syjA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 4 LEU A 331
GLY A 309
SER A 308
SER A 316
None
1.38A 5uunA-3syjA:
undetectable
5uunA-3syjA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
5 / 12 VAL A 105
ASP A 104
ALA A  85
SER A  80
GLY A 101
None
1.07A 6b0iB-3syjA:
undetectable
6b0iB-3syjA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 4 LEU A 793
ASP A 813
GLN A 811
VAL A 742
None
1.38A 6bzoF-3syjA:
undetectable
6bzoF-3syjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 7 ALA A 746
THR A 726
ILE A 732
VAL A 742
None
0.95A 6cduF-3syjA:
undetectable
6cduJ-3syjA:
undetectable
6cduF-3syjA:
15.23
6cduJ-3syjA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 4 ASP A 242
ALA A  86
SER A  95
PHE A 276
None
1.40A 6cm4A-3syjA:
0.0
6cm4A-3syjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
3 / 3 ARG A 187
ARG A 226
ASP A 191
None
0.84A 6d8pA-3syjA:
undetectable
6d8pA-3syjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae)
4 / 5 TYR A 366
VAL A 150
PHE A 394
GLY A 392
None
1.29A 6hd4A-3syjA:
undetectable
6hd4A-3syjA:
6.14