SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3syx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3syx SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A  65
LEU A  34
MET A  22
 None
 0.77A 2itzA-3syxA:
undetectable		 2itzA-3syxA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3syx SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 103
LEU A  76
ARG A 117
ASP A 113
PHE A 112
 None
 1.34A 5nknA-3syxA:
undetectable		 5nknA-3syxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3syx SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 114
PHE A 112
LEU A 101
SER A  41
 None
 1.29A 5uxcA-3syxA:
undetectable		 5uxcA-3syxA:
17.11