SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		3 / 3 THR A 118
PRO A 116
THR A 120
 None
 0.88A 1dscC-3sz4A:
undetectable		 1dscC-3sz4A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		3 / 3 ASP A  90
GLU A 192
TYR A  39
 None
 0.78A 1wsvA-3sz4A:
undetectable		 1wsvA-3sz4A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		4 / 6 GLU A  78
TYR A 165
ASP A 151
ARG A 169
 None
 1.43A 2a3bB-3sz4A:
undetectable		 2a3bB-3sz4A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		3 / 3 THR A 118
PRO A 116
THR A 120
 None
 0.80A 316dC-3sz4A:
undetectable		 316dC-3sz4A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		4 / 5 SER A  19
THR A  17
GLU A 112
ASP A 151
 D5M  A 218 (-2.2A)
D5M  A 218 (-3.4A)
MG  A 217 (-3.0A)
None
 1.18A 3tm4A-3sz4A:
undetectable		 3tm4A-3sz4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		4 / 5 SER A  19
THR A  17
GLU A 112
ASP A 151
 D5M  A 218 (-2.2A)
D5M  A 218 (-3.4A)
MG  A 217 (-3.0A)
None
 1.18A 3tm4B-3sz4A:
undetectable		 3tm4B-3sz4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		5 / 9 ASP A 107
GLY A 106
VAL A  86
THR A  84
GLY A 103
 None
 1.26A 4acaB-3sz4A:
undetectable
4acaC-3sz4A:
undetectable		 4acaB-3sz4A:
19.25
4acaC-3sz4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		5 / 12 ILE A 111
GLY A 103
ARG A 147
VAL A  83
ILE A  76
 None
 1.11A 4rvdA-3sz4A:
undetectable		 4rvdA-3sz4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		5 / 12 ILE A  94
HIS A  91
GLY A  96
GLU A 179
ALA A 189
 None
 1.00A 5ih0A-3sz4A:
1.4		 5ih0A-3sz4A:
24.00