SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 ASN A 681
ALA A 474
ASN A 142
 None
 0.80A 1n4fA-3szeA:
undetectable		 1n4fA-3szeA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 6 ASN A 128
GLY A 264
THR A 114
SER A 134
 None
 0.85A 1n4fA-3szeA:
undetectable		 1n4fA-3szeA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 762
LEU A 794
ALA A 812
VAL A 850
ILE A 738
 None
 1.01A 1s9pC-3szeA:
undetectable		 1s9pC-3szeA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 762
LEU A 794
ALA A 812
VAL A 850
ILE A 738
 None
 1.14A 1s9pD-3szeA:
undetectable		 1s9pD-3szeA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 PHE A 220
SER A 210
ILE A  60
THR A 218
 None
 0.85A 1sbrA-3szeA:
undetectable		 1sbrA-3szeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 PHE A 220
SER A 210
ILE A  60
THR A 218
 None
 0.89A 1sbrB-3szeA:
undetectable		 1sbrB-3szeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 10 ALA A 723
ILE A 708
GLY A 707
GLY A 706
ILE A 667
 None
 0.95A 1sdvA-3szeA:
undetectable		 1sdvA-3szeA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 639
ILE A 556
ASN A 515
LEU A 544
PHE A 646
 None
 1.05A 2bdmA-3szeA:
undetectable		 2bdmA-3szeA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ALA A 710
ILE A 665
ILE A 658
GLY A 707
ILE A 715
 None
 0.92A 2hs1B-3szeA:
undetectable		 2hs1B-3szeA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 MET A 764
ILE A 715
THR A 746
LEU A 762
LEU A 794
 None
 1.37A 2mjiA-3szeA:
undetectable		 2mjiA-3szeA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_B_ADNB1588_1
(ACSD)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 10 LEU A 558
HIS A 535
LEU A 544
GLN A 562
ASN A 515
 None
 1.16A 2w03B-3szeA:
0.0		 2w03B-3szeA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 LEU A 434
LEU A 437
ASN A 458
ARG A 421
 None
 1.01A 2xn3A-3szeA:
undetectable
2xn3B-3szeA:
undetectable		 2xn3A-3szeA:
16.89
2xn3B-3szeA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 TYR A 673
GLN A 691
ILE A 693
SER A 564
 None
 1.03A 2xytE-3szeA:
undetectable		 2xytE-3szeA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 TYR A 673
GLN A 691
ILE A 693
SER A 564
 None
 0.97A 2xytH-3szeA:
undetectable		 2xytH-3szeA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 TYR A 673
GLN A 691
ILE A 693
SER A 564
 None
 0.92A 2xytI-3szeA:
undetectable		 2xytI-3szeA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 11 ALA A 723
ASP A 743
ILE A 738
ILE A 715
ILE A 717
 None
 1.00A 3ebzA-3szeA:
undetectable		 3ebzA-3szeA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 10 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.05A 3fhjA-3szeA:
undetectable		 3fhjA-3szeA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 10 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.05A 3fhjB-3szeA:
undetectable		 3fhjB-3szeA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 10 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.05A 3fhjC-3szeA:
undetectable		 3fhjC-3szeA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.06A 3fhjD-3szeA:
undetectable		 3fhjD-3szeA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 10 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.05A 3fhjE-3szeA:
undetectable		 3fhjE-3szeA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.06A 3fhjF-3szeA:
undetectable		 3fhjF-3szeA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.06A 3fi0A-3szeA:
undetectable		 3fi0A-3szeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.07A 3fi0C-3szeA:
undetectable		 3fi0C-3szeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.03A 3fi0D-3szeA:
undetectable		 3fi0D-3szeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.08A 3fi0H-3szeA:
undetectable		 3fi0H-3szeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.11A 3fi0J-3szeA:
undetectable		 3fi0J-3szeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.02A 3fi0K-3szeA:
undetectable		 3fi0K-3szeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.03A 3fi0N-3szeA:
undetectable		 3fi0N-3szeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 GLY A 431
VAL A 167
ILE A 446
VAL A 455
VAL A 435
 None
 1.08A 3fi0R-3szeA:
undetectable		 3fi0R-3szeA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 866
VAL A 844
MET A 859
LEU A 875
ILE A 814
 None
 1.42A 3h52A-3szeA:
undetectable		 3h52A-3szeA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 ASN A 503
LEU A 482
ASP A 481
SER A 505
 None
 1.06A 3lslA-3szeA:
undetectable
3lslD-3szeA:
undetectable		 3lslA-3szeA:
16.07
3lslD-3szeA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 SER A 505
ASN A 503
LEU A 482
ASP A 481
 None
 1.07A 3lslA-3szeA:
undetectable
3lslD-3szeA:
undetectable		 3lslA-3szeA:
16.07
3lslD-3szeA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 ALA A 723
ILE A 708
ILE A 655
VAL A 648
ILE A 667
 None
 1.02A 3nuoA-3szeA:
undetectable		 3nuoA-3szeA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ASP A 496
VAL A 550
ILE A 556
ILE A 520
ALA A 494
 None
 1.03A 3ohtA-3szeA:
undetectable
3ohtB-3szeA:
undetectable		 3ohtA-3szeA:
18.32
3ohtB-3szeA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 5 ASN A 740
ASP A 743
THR A 746
SER A 791
 None
 1.46A 3p2kC-3szeA:
undetectable		 3p2kC-3szeA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 6 TYR A 673
GLN A 691
ILE A 693
SER A 564
 None
 1.08A 3peoG-3szeA:
undetectable		 3peoG-3szeA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 ALA A 723
ASP A 743
ILE A 738
ILE A 715
ILE A 717
 None
 1.02A 3s45A-3szeA:
undetectable		 3s45A-3szeA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 HIS A 127
ASP A 156
GLY A 261
ALA A 263
ALA A 296
 None
 0.98A 3sudA-3szeA:
8.5		 3sudA-3szeA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 GLY A 741
ILE A 665
GLY A 668
ALA A 721
ALA A 723
 None
 1.07A 3sudB-3szeA:
8.2		 3sudB-3szeA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 HIS A 127
ASP A 156
GLY A 261
ALA A 263
ALA A 296
 None
 0.98A 3sudD-3szeA:
8.5		 3sudD-3szeA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 ALA A 573
PHE A 254
PHE A  78
ALA A  72
 None
 0.97A 3t3sF-3szeA:
undetectable		 3t3sF-3szeA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 LEU A 901
VAL A 952
VAL A 962
LEU A 896
 None
 0.83A 3v81C-3szeA:
undetectable		 3v81C-3szeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 ASP A 551
GLY A 632
THR A 552
PHE A 636
 None
 0.74A 4ac9C-3szeA:
2.5		 4ac9C-3szeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 ILE A 237
ASP A 238
PHE A 251
VAL A 191
 None
 0.83A 4acaC-3szeA:
2.5		 4acaC-3szeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 ILE A 717
PHE A 704
VAL A 729
GLY A 707
 None
 0.83A 4acaC-3szeA:
2.5		 4acaC-3szeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 ASP A 551
GLY A 632
THR A 552
PHE A 636
 None
 0.72A 4acaC-3szeA:
2.5		 4acaC-3szeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 ILE A 237
ASP A 238
PHE A 251
VAL A 191
 None
 0.82A 4acbC-3szeA:
2.4		 4acbC-3szeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 ILE A 717
PHE A 704
VAL A 729
GLY A 707
 None
 0.82A 4acbC-3szeA:
2.4		 4acbC-3szeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ALA A 723
ILE A 708
ILE A 655
VAL A 648
ILE A 667
 None
 0.92A 4dqbA-3szeA:
undetectable		 4dqbA-3szeA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 GLY A 549
VAL A 550
ILE A 501
PHE A 473
 None
 0.91A 4fglD-3szeA:
undetectable		 4fglD-3szeA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 5 HIS A 127
TYR A 225
GLN A 260
GLY A 261
 None
 1.27A 4fu8A-3szeA:
15.6		 4fu8A-3szeA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 6 SER A 143
GLY A 453
ASP A 452
GLY A 477
 None
 0.81A 4koeA-3szeA:
undetectable
4koeB-3szeA:
undetectable
4koeC-3szeA:
undetectable		 4koeA-3szeA:
18.75
4koeB-3szeA:
18.75
4koeC-3szeA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 SER A 143
GLY A 453
ASP A 452
GLY A 477
 None
 0.81A 4koeA-3szeA:
undetectable
4koeB-3szeA:
undetectable
4koeD-3szeA:
undetectable		 4koeA-3szeA:
18.75
4koeB-3szeA:
18.75
4koeD-3szeA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 428
ALA A 459
ILE A 448
LEU A 434
GLY A 451
 None
 1.25A 4l9qA-3szeA:
undetectable		 4l9qA-3szeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 428
ALA A 459
ILE A 448
LEU A 434
GLY A 451
 None
 1.22A 4l9qB-3szeA:
undetectable		 4l9qB-3szeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.41A 4lvcB-3szeA:
undetectable		 4lvcB-3szeA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 6 ILE A 501
ILE A 448
PHE A 489
LEU A 463
 None
 0.85A 4m51A-3szeA:
undetectable		 4m51A-3szeA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 GLY A 261
ALA A 263
VAL A 283
TYR A 298
ASN A 256
 None
 1.22A 4pd5A-3szeA:
undetectable		 4pd5A-3szeA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
THR A 173
ASP A 163
ILE A 413
 None
 1.15A 4pghD-3szeA:
undetectable		 4pghD-3szeA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ALA A 710
ILE A 665
ILE A 658
GLY A 707
ILE A 715
 None
 0.89A 4q1xB-3szeA:
undetectable		 4q1xB-3szeA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 GLN A 533
HIS A 535
ARG A 542
 None
 0.89A 4qyqA-3szeA:
undetectable		 4qyqA-3szeA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 GLN A 533
HIS A 535
ARG A 542
 None
 0.84A 4qyqB-3szeA:
undetectable		 4qyqB-3szeA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ILE A 525
THR A 561
LEU A 546
LEU A 641
LEU A 639
 None
 1.17A 4qzuC-3szeA:
undetectable		 4qzuC-3szeA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 9 VAL A 166
GLY A 171
ALA A 172
THR A 115
ILE A 306
 None
 1.00A 4r21B-3szeA:
undetectable		 4r21B-3szeA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 ALA A 812
SER A 808
ILE A 806
LEU A 872
 None
 0.97A 4uymA-3szeA:
undetectable		 4uymA-3szeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 ASP A 657
GLY A 637
ASP A 555
 None
 0.66A 4xdtA-3szeA:
undetectable		 4xdtA-3szeA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ASN A 653
GLY A 548
ILE A 545
GLN A 691
HIS A 568
 None
 1.44A 4xucA-3szeA:
undetectable		 4xucA-3szeA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 6 GLY A 453
ASP A 452
GLY A 477
SER A 143
 None
 0.83A 4z53A-3szeA:
undetectable
4z53B-3szeA:
undetectable		 4z53A-3szeA:
22.27
4z53B-3szeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 GLY A 453
ASP A 452
GLY A 477
SER A 143
 None
 0.87A 4z53A-3szeA:
undetectable
4z53B-3szeA:
undetectable		 4z53A-3szeA:
22.27
4z53B-3szeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ILE A 471
LEU A 428
THR A 430
LEU A 482
THR A 502
 None
 0.96A 5byjA-3szeA:
undetectable		 5byjA-3szeA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 GLY A 205
ASN A 256
GLY A 264
SER A 113
SER A 259
 None
 1.21A 5hikA-3szeA:
undetectable		 5hikA-3szeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.39A 5hm8A-3szeA:
undetectable		 5hm8A-3szeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.39A 5hm8B-3szeA:
undetectable		 5hm8B-3szeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.39A 5hm8C-3szeA:
undetectable		 5hm8C-3szeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.39A 5hm8D-3szeA:
undetectable		 5hm8D-3szeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.38A 5hm8E-3szeA:
undetectable		 5hm8E-3szeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.39A 5hm8F-3szeA:
undetectable		 5hm8F-3szeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.39A 5hm8G-3szeA:
undetectable		 5hm8G-3szeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 LEU A 162
THR A 148
ASP A 346
HIS A 411
GLY A 364
 None
 1.39A 5hm8H-3szeA:
undetectable		 5hm8H-3szeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 VAL A 898
SER A 877
MET A 815
 None
 0.90A 5ikqA-3szeA:
undetectable		 5ikqA-3szeA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 LEU A 875
TYR A 908
SER A 880
 None
 0.78A 5iktA-3szeA:
undetectable		 5iktA-3szeA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 5 LEU A 244
TYR A 298
LEU A 246
TYR A 287
 None
 1.48A 5ki6A-3szeA:
undetectable		 5ki6A-3szeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 LYS A 213
GLN A 601
ASN A 602
 None
 0.87A 5l2tA-3szeA:
undetectable		 5l2tA-3szeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 ASP A 338
THR A 339
LEU A 332
VAL A 324
 None
 1.06A 5ov9A-3szeA:
undetectable		 5ov9A-3szeA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 GLY A 668
VAL A 648
THR A 705
GLY A 706
GLY A 707
 None
 1.20A 6brdB-3szeA:
undetectable		 6brdB-3szeA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 6 ASN A 231
TYR A  68
VAL A 209
VAL A 211
 None
 1.42A 6f32B-3szeA:
undetectable		 6f32B-3szeA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 10 LEU A 762
VAL A 744
PHE A 725
ILE A 708
THR A 734
 None
 1.03A 6h1lA-3szeA:
undetectable		 6h1lA-3szeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 11 LEU A 762
VAL A 744
PHE A 725
ILE A 708
THR A 734
 None
 1.07A 6h1lB-3szeA:
undetectable		 6h1lB-3szeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3sze SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 6 GLY A 438
LEU A 437
VAL A 378
PHE A 370
 None
 0.93A 6h7lB-3szeA:
undetectable		 6h7lB-3szeA:
7.40