SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A  76
LEU A 133
THR A 248
ALA A  25
THR A 112
 None
 1.09A 1bzfA-3t02A:
2.3		 1bzfA-3t02A:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 5 ASP A 211
HIS A 215
HIS A 251
HIS A 377
 ZN  A 502 (-2.2A)
ZN  A 502 ( 3.3A)
ZN  A 501 ( 3.0A)
ZN  A 502 ( 3.2A)
 0.18A 1ei6A-3t02A:
61.7		 1ei6A-3t02A:
54.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		7 / 8 ASP A  29
PHE A  67
ASP A 211
HIS A 215
HIS A 251
ILE A 287
HIS A 377
 ZN  A 501 ( 2.2A)
None
ZN  A 502 (-2.2A)
ZN  A 502 ( 3.3A)
ZN  A 501 ( 3.0A)
None
ZN  A 502 ( 3.2A)
 0.55A 1ei6C-3t02A:
62.1		 1ei6C-3t02A:
54.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 8 PHE A  67
ASP A  29
HIS A 215
HIS A 251
 None
ZN  A 501 ( 2.2A)
ZN  A 502 ( 3.3A)
ZN  A 501 ( 3.0A)
 0.98A 1ei6D-3t02A:
60.3		 1ei6D-3t02A:
54.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		5 / 8 PHE A  67
ASP A 211
HIS A 215
ILE A 287
HIS A 377
 None
ZN  A 502 (-2.2A)
ZN  A 502 ( 3.3A)
None
ZN  A 502 ( 3.2A)
 0.61A 1ei6D-3t02A:
60.3		 1ei6D-3t02A:
54.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		5 / 8 PHE A 409
LEU A 402
ALA A  60
PHE A 387
VAL A 385
 None
 1.39A 1epbB-3t02A:
undetectable		 1epbB-3t02A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		5 / 11 VAL A  11
TYR A  16
GLY A 121
VAL A 412
PRO A  19
 None
 1.08A 1i9jH-3t02A:
undetectable
1i9jL-3t02A:
undetectable		 1i9jH-3t02A:
18.84
1i9jL-3t02A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A 131
ILE A 166
GLY A 165
GLY A 138
 None
 0.68A 1me7A-3t02A:
undetectable		 1me7A-3t02A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		3 / 3 ASP A  37
LEU A  36
HIS A  61
 None
 0.72A 1qknA-3t02A:
undetectable		 1qknA-3t02A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 378
ASP A 250
PHE A  67
ASP A  29
GLY A  30
 None
ZN  A 501 (-2.4A)
None
ZN  A 501 ( 2.2A)
ZN  A 501 ( 4.8A)
 1.11A 1zz1C-3t02A:
undetectable		 1zz1C-3t02A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 5 VAL A 247
PHE A 408
ILE A  75
PHE A 114
 None
 1.06A 3owxB-3t02A:
undetectable		 3owxB-3t02A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 PHE A  67
ASN A  89
ASP A  29
HIS A 251
 None
None
ZN  A 501 ( 2.2A)
ZN  A 501 ( 3.0A)
 0.85A 3t01A-3t02A:
72.6		 3t01A-3t02A:
99.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		6 / 7 PHE A  67
ASN A  89
ASP A 211
HIS A 215
ILE A 287
HIS A 377
 None
None
ZN  A 502 (-2.2A)
ZN  A 502 ( 3.3A)
None
ZN  A 502 ( 3.2A)
 0.23A 3t01A-3t02A:
72.6		 3t01A-3t02A:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A 351
VAL A 349
LEU A 329
ASN A  71
 None
 0.95A 4e1gB-3t02A:
undetectable		 4e1gB-3t02A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 5 PRO A  70
ASN A  71
ILE A  64
VAL A 385
 None
 1.17A 4hytA-3t02A:
undetectable		 4hytA-3t02A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 ARG A 344
ILE A 345
PRO A  81
ILE A  86
 None
 1.04A 4w5oA-3t02A:
undetectable		 4w5oA-3t02A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 PHE A 231
LEU A  48
THR A 209
VAL A 247
 None
 1.06A 4wnvD-3t02A:
undetectable		 4wnvD-3t02A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 ARG A 344
ILE A 345
PRO A  81
ILE A  86
 None
 1.02A 4z4eA-3t02A:
undetectable		 4z4eA-3t02A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 ARG A 344
ILE A 345
PRO A  81
ILE A  86
 None
 1.04A 4z4gA-3t02A:
undetectable		 4z4gA-3t02A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 3t02 PHOSPHONOACETATE
HYDROLASE
(Sinorhizobium
meliloti) 		4 / 7 ASP A 211
ASP A 250
GLY A 252
TYR A  35
 ZN  A 502 (-2.2A)
ZN  A 501 (-2.4A)
None
None
 1.10A 5hwaA-3t02A:
undetectable		 5hwaA-3t02A:
18.98