SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 6 ALA A 377
SER A 215
TRP A 414
ARG A 392
 None
 1.17A 1gahA-3t05A:
undetectable		 1gahA-3t05A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 11 ALA A 191
ILE A 412
VAL A 200
THR A 275
ALA A 276
 None
 1.14A 1rv7A-3t05A:
undetectable
1rv7B-3t05A:
undetectable		 1rv7A-3t05A:
11.11
1rv7B-3t05A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 11 ALA A 558
VAL A 493
ILE A 476
VAL A 509
VAL A 511
 None
 1.06A 2nnpB-3t05A:
undetectable		 2nnpB-3t05A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 6 ILE A 232
SER A 236
ARG A 204
ILE A 170
 None
 1.00A 2q72A-3t05A:
undetectable		 2q72A-3t05A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 11 ALA A 377
THR A 453
ILE A 451
ILE A 397
VAL A 363
 None
 1.13A 2qhfA-3t05A:
undetectable		 2qhfA-3t05A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 7 PRO A  12
SER A  14
ILE A  10
GLY A 312
 None
 0.97A 2y7kA-3t05A:
undetectable		 2y7kA-3t05A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		3 / 3 TYR A 391
VAL A 351
THR A 387
 None
 0.90A 2ygnA-3t05A:
undetectable		 2ygnA-3t05A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 5 ILE A 301
ARG A 328
MET A 327
THR A 326
 None
 1.37A 3abkN-3t05A:
undetectable
3abkW-3t05A:
undetectable		 3abkN-3t05A:
19.44
3abkW-3t05A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		3 / 3 PRO A 218
PHE A 193
LYS A 219
 None
 1.28A 3bjwG-3t05A:
undetectable		 3bjwG-3t05A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 5 VAL A   7
VAL A  30
THR A 305
THR A   9
 None
 1.24A 3bjwD-3t05A:
undetectable		 3bjwD-3t05A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		3 / 3 ALA A 399
THR A 379
CYH A 410
 None
PO4  A 586 (-3.4A)
None
 0.77A 3e4eA-3t05A:
undetectable		 3e4eA-3t05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		3 / 3 ASN A 446
ASP A 474
ARG A 424
 None
 0.85A 3k13A-3t05A:
9.4		 3k13A-3t05A:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		8 / 10 THR A   9
PRO A  12
ARG A  32
ASN A  34
HIS A  37
GLY A  38
GLY A 312
ALA A 315
 None
 0.43A 3pp7B-3t05A:
57.6		 3pp7B-3t05A:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		3 / 3 GLU A 475
PHE A 578
GLN A 574
 None
 0.84A 3r55A-3t05A:
undetectable		 3r55A-3t05A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 12 GLU A 141
VAL A 117
ILE A 135
ILE A  91
GLU A  89
 None
 1.45A 4a99A-3t05A:
undetectable
4a99C-3t05A:
undetectable		 4a99A-3t05A:
23.76
4a99C-3t05A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 12 VAL A 416
ARG A 408
ALA A 385
THR A 379
GLU A 404
 None
None
None
PO4  A 586 (-3.4A)
None
 1.25A 4fiaA-3t05A:
undetectable		 4fiaA-3t05A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 12 VAL A 416
ARG A 408
ALA A 385
THR A 379
GLU A 404
 None
None
None
PO4  A 586 (-3.4A)
None
 1.25A 4fiaA-3t05A:
undetectable		 4fiaA-3t05A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		3 / 3 SER A 295
ASP A 296
GLN A 259
 None
 0.89A 4oltA-3t05A:
undetectable
4oltB-3t05A:
undetectable		 4oltA-3t05A:
17.93
4oltB-3t05A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		3 / 3 GLN A 259
SER A 295
ASP A 296
 None
 0.93A 4qwpA-3t05A:
undetectable
4qwpB-3t05A:
undetectable		 4qwpA-3t05A:
18.70
4qwpB-3t05A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 9 GLY A 575
VAL A 487
GLY A 483
ILE A 482
ILE A 570
 None
 0.92A 4rvjB-3t05A:
undetectable		 4rvjB-3t05A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 9 GLY A 575
VAL A 487
GLY A 483
ILE A 482
ILE A 570
 None
 0.93A 4rvjD-3t05A:
undetectable		 4rvjD-3t05A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 5 PRO A 272
VAL A 273
ALA A 307
PHE A 217
 None
 1.33A 4w5oA-3t05A:
2.5		 4w5oA-3t05A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 130
LEU A 123
ILE A 121
ILE A  72
VAL A 106
 None
 0.87A 4y0sA-3t05A:
undetectable		 4y0sA-3t05A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 5 PRO A 272
VAL A 273
ALA A 307
PHE A 217
 None
 1.30A 4z4cA-3t05A:
2.2		 4z4cA-3t05A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 5 PRO A 272
VAL A 273
ALA A 307
PHE A 217
 None
 1.32A 4z4dA-3t05A:
2.7		 4z4dA-3t05A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 5 PRO A 272
VAL A 273
ALA A 307
PHE A 217
 None
 1.33A 4z4eA-3t05A:
undetectable		 4z4eA-3t05A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 8 ILE A 112
VAL A 142
GLN A 116
SER A 119
 None
 1.19A 5dqyA-3t05A:
undetectable		 5dqyA-3t05A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 12 ASP A 296
SER A 282
THR A 290
GLU A 313
SER A 311
 None
 1.16A 5hfjD-3t05A:
undetectable		 5hfjD-3t05A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 12 ALA A 276
SER A 282
THR A 290
GLU A 313
SER A 311
 None
 1.20A 5hfjE-3t05A:
undetectable		 5hfjE-3t05A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 9 ILE A 330
VAL A 308
THR A   4
ILE A 301
 None
 0.66A 5lg3I-3t05A:
undetectable		 5lg3I-3t05A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 6 LEU A 239
ILE A 301
THR A 305
MET A 279
 None
 1.37A 5ljeA-3t05A:
undetectable		 5ljeA-3t05A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		5 / 12 GLY A  27
VAL A  61
ALA A 331
MET A 327
VAL A 308
 None
 0.98A 5n0tB-3t05A:
undetectable		 5n0tB-3t05A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3t05 PYRUVATE KINASE
(Staphylococcus
aureus) 		4 / 6 VAL A   7
LEU A 233
ARG A 204
PRO A 218
 None
 1.14A 6brdB-3t05A:
undetectable		 6brdB-3t05A:
9.77