SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		3 / 3 ARG A  94
SER A 130
TYR A 134
 None
 0.71A 1x70A-3t0oA:
undetectable		 1x70A-3t0oA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		4 / 6 LEU A 128
TRP A  97
MET A  93
LEU A  89
 None
 1.43A 2oz7A-3t0oA:
undetectable		 2oz7A-3t0oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		4 / 6 ASP A  99
VAL A 100
PHE A 104
PRO A 105
 None
 1.41A 2q6oB-3t0oA:
undetectable		 2q6oB-3t0oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		4 / 6 TYR A 176
ASN A 148
LEU A 147
ASP A 146
 None
 1.34A 3lslG-3t0oA:
undetectable		 3lslG-3t0oA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		5 / 12 GLN A  41
ILE A 182
GLY A 197
GLU A  45
TYR A 248
 None
 1.10A 4r29D-3t0oA:
undetectable		 4r29D-3t0oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		3 / 3 LYS A 117
HIS A 113
HIS A 118
 None
 1.41A 5oexA-3t0oA:
undetectable		 5oexA-3t0oA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		3 / 3 LYS A 117
HIS A 113
HIS A 118
 None
 1.45A 5oexB-3t0oA:
undetectable		 5oexB-3t0oA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		3 / 3 LYS A 117
HIS A 113
HIS A 118
 None
 1.43A 5oexC-3t0oA:
undetectable		 5oexC-3t0oA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		3 / 3 LYS A 117
HIS A 113
HIS A 118
 None
 1.41A 5oexD-3t0oA:
undetectable		 5oexD-3t0oA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3t0o RIBONUCLEASE T2
(Homo
sapiens) 		5 / 12 SER A 103
VAL A  40
GLN A 183
LEU A 238
VAL A  47
 None
 1.22A 5tudD-3t0oA:
undetectable		 5tudD-3t0oA:
19.20