SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 ILE A 282
LEU A 328
ILE A 258
LEU A 338
THR A 271
 None
 1.18A 1ddsB-3t0pA:
undetectable		 1ddsB-3t0pA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 ILE A 282
LEU A 328
ILE A 258
LEU A 338
THR A 271
 None
 1.07A 1ra3A-3t0pA:
undetectable		 1ra3A-3t0pA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 6 LEU A 328
MET A 284
LEU A 338
ILE A 357
 None
 1.02A 1z95A-3t0pA:
undetectable		 1z95A-3t0pA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 LEU A  10
ASN A   9
LEU A  11
ALA A   8
LEU A  81
 None
 1.12A 2aa6A-3t0pA:
undetectable		 2aa6A-3t0pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 5 PRO A 343
ALA A 345
ASP A 288
ASP A 253
 None
 1.19A 2nyuB-3t0pA:
undetectable		 2nyuB-3t0pA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 ILE A 282
LEU A 328
ILE A 258
LEU A 338
THR A 271
 None
 1.06A 2zzaA-3t0pA:
undetectable		 2zzaA-3t0pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 11 ILE A 282
LEU A 328
ILE A 258
LEU A 338
THR A 271
 None
 1.05A 2zzaB-3t0pA:
undetectable		 2zzaB-3t0pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 ILE A   4
ILE A  42
ILE A  35
LEU A  69
PHE A  94
 None
 1.12A 3w68C-3t0pA:
undetectable		 3w68C-3t0pA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 8 ASP A 352
ASP A 311
ASN A 337
GLU A 335
 None
 0.77A 4feuD-3t0pA:
undetectable		 4feuD-3t0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 7 ASP A 352
ASP A 311
ASN A 337
GLU A 335
 None
 0.78A 4fevB-3t0pA:
undetectable		 4fevB-3t0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 7 ASP A 352
ASP A 311
ASN A 337
GLU A 335
 None
 0.78A 4fewB-3t0pA:
undetectable		 4fewB-3t0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 8 ASP A 352
ASP A 311
ASN A 337
GLU A 335
 None
 0.79A 4gkhD-3t0pA:
undetectable		 4gkhD-3t0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 8 ASP A 352
ASP A 311
ASN A 337
GLU A 335
 None
 1.11A 4gkiC-3t0pA:
undetectable		 4gkiC-3t0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 8 ASP A 352
ASP A 311
ASN A 337
GLU A 335
 None
 0.99A 4gkiE-3t0pA:
undetectable
4gkiG-3t0pA:
undetectable		 4gkiE-3t0pA:
22.08
4gkiG-3t0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 LEU A   3
ILE A  98
ILE A 107
GLY A 109
ILE A  88
 None
 1.02A 4q1yB-3t0pA:
undetectable		 4q1yB-3t0pA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		4 / 5 GLU A 160
TYR A 241
ILE A 244
TYR A 180
 EDO  A 386 (-3.9A)
None
None
None
 1.39A 4qwpB-3t0pA:
undetectable		 4qwpB-3t0pA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 ILE A 282
LEU A 328
ILE A 258
LEU A 338
THR A 271
 None
 1.10A 4rgcA-3t0pA:
undetectable		 4rgcA-3t0pA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 TYR A 117
LEU A  34
GLY A  65
ALA A  37
SER A  38
 None
 0.93A 4rrxA-3t0pA:
undetectable		 4rrxA-3t0pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 TYR A 117
LEU A  34
GLY A  65
ALA A  37
SER A  38
 None
 0.94A 4rrxB-3t0pA:
undetectable		 4rrxB-3t0pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		3 / 3 LYS A 313
ILE A 315
ILE A 317
 None
 0.68A 4y0qA-3t0pA:
undetectable		 4y0qA-3t0pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 12 ILE A  16
SER A  18
PHE A 227
GLY A 208
LEU A 134
 None
 1.06A 5m24A-3t0pA:
undetectable		 5m24A-3t0pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		5 / 10 ILE A  61
MET A   1
ILE A  66
ILE A  35
ILE A  67
 None
 1.09A 5murE-3t0pA:
undetectable		 5murE-3t0pA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3t0p DNA POLYMERASE III,
BETA SUBUNIT
([Eubacterium]
rectale) 		3 / 3 CYH A 266
MET A 302
ASN A 303
 None
 1.36A 5qh8A-3t0pA:
undetectable		 5qh8A-3t0pA:
20.38