SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		4 / 8 LEU A 124
TYR A  18
GLY A  98
LEU A 131
 None
 1.03A 1s1xA-3t12A:
undetectable		 1s1xA-3t12A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		5 / 12 HIS A  75
GLY A  98
LEU A 189
VAL A 192
ILE A  11
 None
 1.20A 1zq9A-3t12A:
undetectable		 1zq9A-3t12A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3t12 GLIDING PROTEIN MGLB
(Thermus
thermophilus) 		4 / 5 LEU B 115
ARG B  25
TRP B  49
TYR B  95
 None
 1.37A 2zlcA-3t12B:
undetectable		 2zlcA-3t12B:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		5 / 9 LEU A 124
VAL A  96
TYR A  18
GLY A  98
LEU A 131
 None
 1.32A 3lp0A-3t12A:
undetectable		 3lp0A-3t12A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		5 / 11 THR A  26
GLY A  24
GLY A  81
PRO A  80
ASP A 104
 MG  A 198 ( 3.1A)
GDP  A 197 (-3.2A)
ALF  A 200 (-3.6A)
ALF  A 200 (-4.9A)
None
 1.30A 3t8nD-3t12A:
undetectable
3t8nF-3t12A:
undetectable		 3t8nD-3t12A:
19.70
3t8nF-3t12A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3t12 GLIDING PROTEIN MGLA
GLIDING PROTEIN MGLB
(Thermus
thermophilus) 		4 / 7 ASP B  57
ASN A  86
GLU A 126
GLU A 115
 None
 1.23A 4fexB-3t12B:
undetectable		 4fexB-3t12B:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 3t12 GLIDING PROTEIN MGLB
(Thermus
thermophilus) 		5 / 12 LEU B 105
LEU B  34
LEU B  42
ALA B  43
THR B  23
 None
 1.13A 4fn9A-3t12B:
undetectable		 4fn9A-3t12B:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		4 / 8 ILE A  64
GLU A 179
VAL A  36
PRO A  37
 None
 0.70A 4jltA-3t12A:
undetectable		 4jltA-3t12A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		4 / 4 VAL A 137
THR A 180
GLU A 183
GLU A 179
 None
 1.43A 4l78A-3t12A:
undetectable		 4l78A-3t12A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		3 / 3 MET A 120
GLN A  82
TYR A  85
 None
ALF  A 200 (-3.8A)
None
 0.73A 4udcA-3t12A:
undetectable		 4udcA-3t12A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3t12 GLIDING PROTEIN MGLB
(Thermus
thermophilus) 		5 / 12 VAL B  96
GLU B 101
ALA B  68
ALA B  67
VAL B  63
 None
 1.05A 5igjA-3t12B:
undetectable		 5igjA-3t12B:
21.59