SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t1i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 10 PHE A 153
VAL A 215
VAL A 150
ILE A 143
LEU A  61
 None
 0.89A 1fe2A-3t1iA:
undetectable		 1fe2A-3t1iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 4 ILE A 395
LEU A 365
VAL A 367
ALA A 315
 None
 1.00A 1mz9A-3t1iA:
undetectable		 1mz9A-3t1iA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 5 ILE A 395
LEU A 365
VAL A 367
ALA A 315
 None
 0.94A 1mz9C-3t1iA:
undetectable		 1mz9C-3t1iA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 ASP A  60
HIS A 129
HIS A  22
 MN  A 413 ( 2.9A)
GOL  A 454 (-3.8A)
MN  A 412 (-3.4A)
 0.59A 1oe1A-3t1iA:
undetectable		 1oe1A-3t1iA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 ASP A  60
HIS A 129
HIS A  22
 MN  A 413 ( 2.9A)
GOL  A 454 (-3.8A)
MN  A 412 (-3.4A)
 0.58A 1oe3A-3t1iA:
undetectable		 1oe3A-3t1iA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 THR A  19
GLU A 278
HIS A  63
 None
 0.81A 1xwfA-3t1iA:
undetectable		 1xwfA-3t1iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 THR A  19
GLU A 278
HIS A  63
 None
 0.85A 1xwfB-3t1iA:
undetectable		 1xwfB-3t1iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 THR A  19
GLU A 278
HIS A  63
 None
 0.80A 1xwfC-3t1iA:
undetectable		 1xwfC-3t1iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 THR A  19
GLU A 278
HIS A  63
 None
 0.84A 1xwfD-3t1iA:
undetectable		 1xwfD-3t1iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 12 ASP A  20
HIS A 152
GLY A  59
HIS A 126
GLY A 154
 MN  A 412 (-3.1A)
None
None
None
None
 1.12A 1zz1C-3t1iA:
undetectable		 1zz1C-3t1iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 9 LEU A 178
LEU A 168
LEU A 169
ILE A  93
PHE A 123
 None
 1.29A 2f7aA-3t1iA:
undetectable		 2f7aA-3t1iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 ASP A  60
HIS A 129
HIS A  22
 MN  A 413 ( 2.9A)
GOL  A 454 (-3.8A)
MN  A 412 (-3.4A)
 0.60A 2xxgA-3t1iA:
undetectable		 2xxgA-3t1iA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 ASP A  60
HIS A 129
HIS A  22
 MN  A 413 ( 2.9A)
GOL  A 454 (-3.8A)
MN  A 412 (-3.4A)
 0.62A 2xxgC-3t1iA:
undetectable		 2xxgC-3t1iA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 7 PRO A  67
SER A  68
PHE A  37
GLY A  24
 None
 0.91A 2y7kA-3t1iA:
undetectable		 2y7kA-3t1iA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 12 LEU A  57
GLY A  58
GLY A 244
VAL A 241
LEU A 141
 None
 1.19A 3cjtG-3t1iA:
undetectable		 3cjtG-3t1iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 GLU A  42
SER A 269
VAL A 270
 None
 0.84A 3eeoA-3t1iA:
undetectable		 3eeoA-3t1iA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 10 GLY A 267
GLN A 265
ASP A  20
ILE A  21
VAL A 284
 None
None
MN  A 412 (-3.1A)
None
None
 1.36A 3fhjA-3t1iA:
undetectable		 3fhjA-3t1iA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 9 GLY A 267
GLN A 265
ASP A  20
ILE A  21
VAL A 284
 None
None
MN  A 412 (-3.1A)
None
None
 1.36A 3fi0A-3t1iA:
undetectable		 3fi0A-3t1iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 9 GLY A 267
GLN A 265
ASP A  20
ILE A  21
VAL A 284
 None
None
MN  A 412 (-3.1A)
None
None
 1.32A 3fi0M-3t1iA:
undetectable		 3fi0M-3t1iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 12 VAL A 122
LEU A  57
VAL A  52
ALA A  47
LEU A  44
 None
 1.25A 3pghA-3t1iA:
undetectable		 3pghA-3t1iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 8 ASN A 128
SER A 221
HIS A 223
ASP A 186
 MN  A 413 ( 2.2A)
None
None
None
 0.88A 3sg9B-3t1iA:
undetectable		 3sg9B-3t1iA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 12 LEU A 213
ILE A 164
ILE A 242
ILE A 263
ASP A 235
 None
 1.23A 3uj7A-3t1iA:
undetectable		 3uj7A-3t1iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 7 HIS A  22
HIS A 247
HIS A 245
HIS A 217
 MN  A 412 (-3.4A)
MN  A 412 (-3.4A)
MN  A 413 (-3.4A)
MN  A 413 (-3.5A)
 0.99A 4p6sB-3t1iA:
undetectable		 4p6sB-3t1iA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 7 ILE A 263
GLN A 265
PRO A 266
ASP A  20
 None
None
None
MN  A 412 (-3.1A)
 0.84A 4w5oA-3t1iA:
undetectable		 4w5oA-3t1iA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 7 ILE A 263
GLN A 265
PRO A 266
ASP A  20
 None
None
None
MN  A 412 (-3.1A)
 0.80A 4z4eA-3t1iA:
undetectable		 4z4eA-3t1iA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 7 ILE A 263
GLN A 265
PRO A 266
ASP A  20
 None
None
None
MN  A 412 (-3.1A)
 0.84A 4z4gA-3t1iA:
3.3		 4z4gA-3t1iA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 6 CYH A  75
LEU A  40
CYH A  83
LEU A  44
 None
 1.14A 5hpuC-3t1iA:
undetectable
5hpuD-3t1iA:
undetectable		 5hpuC-3t1iA:
3.76
5hpuD-3t1iA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 6 ASP A  60
ASP A  20
HIS A  22
HIS A 247
HIS A 217
 MN  A 413 ( 2.9A)
MN  A 412 (-3.1A)
MN  A 412 (-3.4A)
MN  A 412 (-3.4A)
MN  A 413 (-3.5A)
 1.08A 5ncdB-3t1iA:
undetectable
5ncdC-3t1iA:
undetectable		 5ncdB-3t1iA:
20.87
5ncdC-3t1iA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 4 ASP A  60
HIS A 217
HIS A 245
HIS A 129
 MN  A 413 ( 2.9A)
MN  A 413 (-3.5A)
MN  A 413 (-3.4A)
GOL  A 454 (-3.8A)
 1.47A 5ncdD-3t1iA:
undetectable		 5ncdD-3t1iA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 6 ASP A  60
ASP A  20
HIS A  22
HIS A 247
HIS A 217
 MN  A 413 ( 2.9A)
MN  A 412 (-3.1A)
MN  A 412 (-3.4A)
MN  A 412 (-3.4A)
MN  A 413 (-3.5A)
 1.06A 5nelA-3t1iA:
undetectable
5nelD-3t1iA:
undetectable		 5nelA-3t1iA:
20.87
5nelD-3t1iA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 6 ASP A  60
HIS A  22
HIS A 247
HIS A 217
 MN  A 413 ( 2.9A)
MN  A 412 (-3.4A)
MN  A 412 (-3.4A)
MN  A 413 (-3.5A)
 1.00A 5nelB-3t1iA:
undetectable
5nelC-3t1iA:
undetectable		 5nelB-3t1iA:
20.87
5nelC-3t1iA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 12 ARG A 155
PHE A 153
GLY A 154
GLY A 180
ILE A 216
 None
 1.11A 5ul4A-3t1iA:
3.2		 5ul4A-3t1iA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		3 / 3 HIS A 302
HIS A 356
ARG A  45
 GOL  A 457 (-3.7A)
GOL  A 457 (-4.2A)
None
 0.91A 6b58A-3t1iA:
undetectable		 6b58A-3t1iA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 12 LEU A 201
VAL A 241
ARG A 202
ILE A 238
ASP A 239
 None
 1.37A 6bxnA-3t1iA:
undetectable		 6bxnA-3t1iA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 12 LEU A 201
VAL A 241
ARG A 202
ILE A 238
ASP A 239
 None
 1.34A 6bxnB-3t1iA:
undetectable		 6bxnB-3t1iA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		4 / 8 ASP A 136
ARG A 155
VAL A 150
GLN A 218
 None
 1.08A 6fbvD-3t1iA:
0.0		 6fbvD-3t1iA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens) 		5 / 12 LEU A  57
GLY A  59
ASP A 239
ILE A 238
SER A 124
 None
 0.86A 6mhtA-3t1iA:
undetectable		 6mhtA-3t1iA:
23.29