SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		4 / 6 LEU A 353
LEU A 172
LEU A  80
LEU A  77
 None
 0.86A 1errA-3t1pA:
undetectable		 1errA-3t1pA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		5 / 12 PHE A 312
LEU A 329
ALA A 332
LEU A 299
ILE A  76
 None
 1.01A 1mx8A-3t1pA:
undetectable		 1mx8A-3t1pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		5 / 9 LEU A  77
LEU A  30
ILE A  26
ALA A  58
THR A  59
 None
 1.04A 3mdvA-3t1pA:
undetectable		 3mdvA-3t1pA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		4 / 6 TYR A  38
VAL A 333
VAL A 302
ILE A  57
 None
 1.02A 3pyyA-3t1pA:
undetectable		 3pyyA-3t1pA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		4 / 5 PHE A  61
PHE A 312
ILE A 308
GLY A 304
 None
 1.01A 4ejjC-3t1pA:
undetectable		 4ejjC-3t1pA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		4 / 7 ALA A 250
THR A 249
ALA A 248
THR A 345
 None
 0.96A 4qw0K-3t1pA:
undetectable		 4qw0K-3t1pA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		4 / 7 ALA A 250
THR A 249
ALA A 248
THR A 345
 None
 0.96A 4qw0Y-3t1pA:
undetectable		 4qw0Y-3t1pA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		5 / 9 LEU A 306
GLY A 307
ILE A  57
MET A 351
LEU A 299
 None
 1.19A 4x3mB-3t1pA:
undetectable		 4x3mB-3t1pA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		4 / 8 ILE A  87
LEU A  84
ILE A  92
LEU A  77
 None
 0.81A 4zvcA-3t1pA:
undetectable
4zvcB-3t1pA:
undetectable		 4zvcA-3t1pA:
17.31
4zvcB-3t1pA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		4 / 8 ILE A  92
LEU A  77
ILE A  87
LEU A  84
 None
 0.81A 4zvcA-3t1pA:
undetectable
4zvcB-3t1pA:
undetectable		 4zvcA-3t1pA:
17.31
4zvcB-3t1pA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3t1p ALPHA-1-ANTITRYPSIN
(Homo
sapiens) 		4 / 7 VAL A 145
PRO A 326
PHE A 182
LEU A 327
 None
 0.97A 6aycA-3t1pA:
undetectable		 6aycA-3t1pA:
14.15