SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo
sapiens)
4 / 8 ARG A1392
ASN A1398
SER A1394
ARG A1442
None
1.21A 1u1jA-3t1wA:
undetectable
1u1jA-3t1wA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo
sapiens)
5 / 12 GLY A1308
GLY A1306
THR A1356
GLU A1329
ILE A1283
None
1.05A 2oxtA-3t1wA:
undetectable
2oxtA-3t1wA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo
sapiens)
3 / 3 ASP A1277
THR A1439
PRO A1440
None
0.71A 2qakB-3t1wA:
undetectable
2qakB-3t1wA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo
sapiens)
5 / 10 PHE A1275
THR A1351
VAL A1303
ILE A1283
VAL A1325
None
1.50A 2qboA-3t1wA:
undetectable
2qboA-3t1wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo
sapiens)
5 / 9 VAL A1414
ILE A1407
ALA A1403
VAL A1427
VAL A1429
None
1.25A 3me6C-3t1wA:
undetectable
3me6C-3t1wA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo
sapiens)
5 / 9 VAL A1414
ILE A1407
ALA A1403
VAL A1427
VAL A1429
None
1.22A 3me6D-3t1wA:
undetectable
3me6D-3t1wA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo
sapiens)
4 / 6 GLY A1422
THR A1423
LEU A1420
ASP A1450
None
0.81A 3ps9A-3t1wA:
undetectable
3ps9A-3t1wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo
sapiens)
4 / 6 ILE A1203
THR A1200
VAL A1225
SER A1256
None
1.12A 4iaqA-3t1wA:
undetectable
4iaqA-3t1wA:
20.63