SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 202
GLY A 174
LEU A 278
TYR A 206
 None
 0.81A 1jlbA-3t20A:
undetectable		 1jlbA-3t20A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 202
GLY A 174
LEU A 278
TYR A 206
 None
 0.76A 1s1xA-3t20A:
undetectable		 1s1xA-3t20A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		5 / 10 ASN A 287
GLU A 343
ASN A 345
GLU A 347
ARG A 363
 None
 1.46A 2piwA-3t20A:
undetectable		 2piwA-3t20A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		3 / 3 SER A 200
TYR A 199
HIS A 198
 None
 0.80A 2r2vD-3t20A:
undetectable		 2r2vD-3t20A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 250
ASP A 227
ARG A 365
 None
 0.88A 3k13A-3t20A:
undetectable		 3k13A-3t20A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		4 / 8 SER A 116
LEU A 114
PRO A 119
GLN A 127
 None
 1.22A 4j7uD-3t20A:
undetectable		 4j7uD-3t20A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		4 / 6 PHE A  16
ILE A 383
ARG A 363
ARG A 381
 None
 1.19A 4mk4B-3t20A:
undetectable		 4mk4B-3t20A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  40
ASP A  56
GLN A  43
ALA A   9
ILE A 111
 None
 1.40A 4uuuA-3t20A:
undetectable
4uuuB-3t20A:
undetectable		 4uuuA-3t20A:
17.94
4uuuB-3t20A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		4 / 5 SER A 281
ASN A 246
GLN A 208
ASP A 273
 None
 1.46A 5kpcA-3t20A:
undetectable		 5kpcA-3t20A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		3 / 3 MET A 321
GLU A 343
ARG A 323
 None
 0.93A 5tjzA-3t20A:
undetectable		 5tjzA-3t20A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 3t20 CIS-ACONITATE PORIN
OPDH
(Pseudomonas
aeruginosa) 		4 / 8 GLY A   2
GLN A  48
THR A  47
SER A   7
 None
 1.04A 6eqpA-3t20A:
undetectable		 6eqpA-3t20A:
15.59