SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t24'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 123
ARG A 124
GLN A 128
ASP A 285
 SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
 1.25A 1rs6A-3t24A:
undetectable		 1rs6A-3t24A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 123
ARG A 124
GLN A 128
ASP A 285
 SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
 1.27A 1rs6B-3t24A:
undetectable		 1rs6B-3t24A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 123
ARG A 124
GLN A 128
ASP A 285
 SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
 1.30A 1rs7B-3t24A:
undetectable		 1rs7B-3t24A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 169
GLY A 168
ASP A 334
ASP A 331
GLY A 330
 None
 0.73A 1sqfA-3t24A:
undetectable		 1sqfA-3t24A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 123
ARG A 124
GLN A 128
ASP A 285
 SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
 1.23A 1zzqA-3t24A:
undetectable		 1zzqA-3t24A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 123
ARG A 124
GLN A 128
ASP A 285
 SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
 1.26A 1zzqB-3t24A:
undetectable		 1zzqB-3t24A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 123
ARG A 124
GLN A 128
ASP A 285
 SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
 1.25A 1zzuA-3t24A:
undetectable		 1zzuA-3t24A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 111
PRO A 113
LEU A 150
ARG A 149
 None
None
None
C8E  A 401 ( 4.4A)
 1.23A 2pnjB-3t24A:
undetectable		 2pnjB-3t24A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		5 / 12 SER A 201
SER A 239
PHE A 185
ILE A 281
LEU A 252
 None
 1.33A 3aocC-3t24A:
undetectable		 3aocC-3t24A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 4 PRO A 116
TYR A 215
GLY A 217
THR A 200
 None
None
None
C8E  A 404 (-3.9A)
 1.43A 3ib0A-3t24A:
undetectable		 3ib0A-3t24A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 123
ARG A 124
GLN A 128
ASP A 285
 SO4  A 397 (-2.4A)
SO4  A 397 ( 3.7A)
None
None
 1.18A 3n62B-3t24A:
undetectable		 3n62B-3t24A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  19
ASP A 157
GLN A 155
 None
 0.69A 4azsA-3t24A:
undetectable		 4azsA-3t24A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 125
ARG A  13
ILE A  58
ASN A 161
 None
 1.45A 4i00A-3t24A:
undetectable		 4i00A-3t24A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		3 / 3 MET A 324
GLU A 346
ARG A 326
 None
None
SO4  A 400 (-3.0A)
 0.94A 5tjzA-3t24A:
undetectable		 5tjzA-3t24A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 375
THR A 374
ILE A 333
GLU A 341
 None
 1.31A 5uigA-3t24A:
undetectable		 5uigA-3t24A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 131
LYS A 151
LEU A 150
LEU A 111
 None
 0.87A 5yvnA-3t24A:
undetectable		 5yvnA-3t24A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 118
PHE A 185
TYR A 211
THR A 167
 None
 1.26A 5z84N-3t24A:
undetectable
5z84W-3t24A:
undetectable		 5z84N-3t24A:
21.66
5z84W-3t24A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3t24 PORIN
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 376
GLN A 173
GLU A 302
THR A 374
 None
 1.34A 6djzA-3t24A:
undetectable		 6djzA-3t24A:
19.05