SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A  98
ASP A  96
GLY A 231
TYR A 358
HIS A  18
 None
MG  A 408 ( 4.1A)
13P  A 411 (-3.1A)
13P  A 412 (-4.1A)
MG  A 410 (-3.3A)
 1.26A 1tmxB-3t2cA:
undetectable		 1tmxB-3t2cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		3 / 3 TRP A  74
LEU A  72
LYS A  32
 None
 1.17A 1yajK-3t2cA:
undetectable		 1yajK-3t2cA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 5 GLU A 135
PRO A 136
ILE A 201
GLY A 137
 None
 1.00A 2qeuA-3t2cA:
undetectable
2qeuC-3t2cA:
undetectable		 2qeuA-3t2cA:
17.07
2qeuC-3t2cA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 8 HIS A 310
ILE A  43
ASP A  44
ARG A 286
 None
 0.96A 2v57A-3t2cA:
undetectable		 2v57A-3t2cA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 8 HIS A 310
ILE A  43
ASP A  44
ARG A 286
 None
 0.95A 2v57C-3t2cA:
undetectable		 2v57C-3t2cA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 6 LEU A 237
PRO A 235
PRO A 142
LEU A 273
 None
 1.00A 3q1eA-3t2cA:
undetectable
3q1eC-3t2cA:
undetectable		 3q1eA-3t2cA:
14.14
3q1eC-3t2cA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 6 PRO A 142
LEU A 273
LEU A 237
PRO A 235
 None
 0.91A 3q1eA-3t2cA:
undetectable
3q1eC-3t2cA:
undetectable		 3q1eA-3t2cA:
14.14
3q1eC-3t2cA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		3 / 3 PRO A 235
ASP A 233
GLU A 135
 None
 0.80A 3v4tC-3t2cA:
undetectable		 3v4tC-3t2cA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 5 ASP A  44
GLU A 315
TYR A 313
GLN A  37
 None
 1.44A 3w9tB-3t2cA:
undetectable		 3w9tB-3t2cA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 5 ASP A  44
GLU A 315
TYR A 313
GLN A  37
 None
 1.49A 3w9tD-3t2cA:
undetectable		 3w9tD-3t2cA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 8 ILE A 202
PHE A 168
THR A 152
THR A 153
 None
 0.78A 4n16A-3t2cA:
undetectable		 4n16A-3t2cA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		3 / 3 SER A  55
GLU A 220
GLU A 169
 None
 0.84A 4ymgB-3t2cA:
undetectable		 4ymgB-3t2cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		4 / 7 ASP A  96
GLY A  94
HIS A  18
ASP A  11
 MG  A 408 ( 4.1A)
None
MG  A 410 (-3.3A)
MG  A 410 ( 2.6A)
 1.09A 5no9D-3t2cA:
undetectable		 5no9D-3t2cA:
11.30