SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 3t2l PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		4 / 8 LEU A 297
SER A 178
ARG A 179
GLY A 236
 None
 0.97A 1fapB-3t2lA:
undetectable		 1fapB-3t2lA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3t2l PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 140
ASP A 221
ASP A 227
TYR A 239
 None
 1.11A 3havA-3t2lA:
undetectable		 3havA-3t2lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3t2l PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		3 / 3 THR A 226
ASP A 227
ALA A 228
 None
 0.05A 5g5gB-3t2lA:
undetectable		 5g5gB-3t2lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3t2l PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		4 / 8 GLN A 289
ILE A 134
ALA A 207
VAL A 208
 None
GOL  A 332 (-4.5A)
None
None
 0.91A 6hu9a-3t2lA:
undetectable
6hu9e-3t2lA:
undetectable		 6hu9a-3t2lA:
20.20
6hu9e-3t2lA:
16.29