SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 8 HIS A 203
SER A 353
VAL A 375
GLY A 388
 None
 0.35A 1aq7A-3t2nA:
25.5		 1aq7A-3t2nA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		5 / 12 LEU A  96
LEU A 278
GLY A  94
ALA A  98
LEU A  99
 None
 0.95A 1gs4A-3t2nA:
undetectable		 1gs4A-3t2nA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 8 PHE A 357
LEU A 285
GLY A 288
ASP A 287
 None
 1.02A 1rmtC-3t2nA:
undetectable		 1rmtC-3t2nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 6 THR A 128
GLU A 133
LEU A 131
ARG A 130
 None
 1.05A 1s8fB-3t2nA:
undetectable		 1s8fB-3t2nA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 6 LEU A 212
ALA A 236
SER A 264
SER A 265
 None
 1.03A 1tz8C-3t2nA:
undetectable
1tz8D-3t2nA:
undetectable		 1tz8C-3t2nA:
18.06
1tz8D-3t2nA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.88A 1zzrA-3t2nL:
undetectable
1zzrB-3t2nL:
undetectable		 1zzrA-3t2nL:
20.26
1zzrB-3t2nL:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.89A 1zzrA-3t2nL:
undetectable
1zzrB-3t2nL:
undetectable		 1zzrA-3t2nL:
20.26
1zzrB-3t2nL:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.90A 1zzuA-3t2nL:
undetectable
1zzuB-3t2nL:
undetectable		 1zzuA-3t2nL:
20.26
1zzuB-3t2nL:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.89A 1zzuA-3t2nL:
undetectable
1zzuB-3t2nL:
undetectable		 1zzuA-3t2nL:
20.26
1zzuB-3t2nL:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 5 THR A 292
ARG A 313
ALA A 312
ARG A 167
 None
 1.27A 2qhfA-3t2nA:
undetectable		 2qhfA-3t2nA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 8 HIS A 262
SER A 408
ASP A 196
ARG A  97
 None
 1.41A 2rk8A-3t2nA:
undetectable		 2rk8A-3t2nA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 7 HIS A 262
SER A 408
ASP A 196
ARG A  97
 None
 1.34A 2rk8B-3t2nA:
undetectable		 2rk8B-3t2nA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VTB_B_ACTB1500_0
(CRYPTOCHROME DASH)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 4 ARG A  62
PHE A 117
VAL A 106
ASP A 105
 None
 1.23A 2vtbB-3t2nA:
0.0		 2vtbB-3t2nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 8 ASN A 254
SER A 255
VAL A 389
ASN A 319
 None
 1.22A 2wekA-3t2nA:
undetectable		 2wekA-3t2nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 8 ASN A 254
SER A 255
VAL A 389
ASN A 319
 None
 1.25A 2wekB-3t2nA:
undetectable		 2wekB-3t2nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 6 LEU A 269
THR A 270
LEU A 230
ASP A 196
 None
 1.04A 2wm3A-3t2nA:
undetectable		 2wm3A-3t2nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		5 / 12 LEU A 199
VAL A 198
ASP A 257
SER A 251
PHE A 246
 None
 1.41A 2y00A-3t2nA:
undetectable		 2y00A-3t2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		5 / 12 LEU A 199
VAL A 198
ASP A 257
SER A 251
PHE A 246
 None
 1.45A 2y00B-3t2nA:
undetectable		 2y00B-3t2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		5 / 12 LEU A 199
VAL A 198
ASP A 257
SER A 251
PHE A 246
 None
 1.43A 2y01B-3t2nA:
undetectable		 2y01B-3t2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 LEU L 133
ALA L 131
LEU L 179
THR L 182
 None
 1.03A 3cfqA-3t2nL:
undetectable
3cfqB-3t2nL:
undetectable		 3cfqA-3t2nL:
24.88
3cfqB-3t2nL:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.90A 3dqrA-3t2nL:
undetectable
3dqrB-3t2nL:
undetectable		 3dqrA-3t2nL:
20.15
3dqrB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.86A 3jx2A-3t2nL:
undetectable
3jx2B-3t2nL:
undetectable		 3jx2A-3t2nL:
20.15
3jx2B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.88A 3jx2A-3t2nL:
undetectable
3jx2B-3t2nL:
undetectable		 3jx2A-3t2nL:
20.15
3jx2B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.92A 3jx3A-3t2nL:
undetectable
3jx3B-3t2nL:
undetectable		 3jx3A-3t2nL:
20.15
3jx3B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.87A 3jx3A-3t2nL:
undetectable
3jx3B-3t2nL:
undetectable		 3jx3A-3t2nL:
20.15
3jx3B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 VAL L 106
ARG L  61
VAL L  19
PHE L  62
 None
 1.43A 3jx4A-3t2nL:
undetectable
3jx4B-3t2nL:
undetectable		 3jx4A-3t2nL:
20.15
3jx4B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.89A 3jx4A-3t2nL:
undetectable
3jx4B-3t2nL:
undetectable		 3jx4A-3t2nL:
20.15
3jx4B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.87A 3jx5A-3t2nL:
undetectable
3jx5B-3t2nL:
undetectable		 3jx5A-3t2nL:
20.15
3jx5B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.88A 3jx5A-3t2nL:
undetectable
3jx5B-3t2nL:
undetectable		 3jx5A-3t2nL:
20.15
3jx5B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.84A 3jx6A-3t2nL:
undetectable
3jx6B-3t2nL:
undetectable		 3jx6A-3t2nL:
20.15
3jx6B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.87A 3jx6A-3t2nL:
undetectable
3jx6B-3t2nL:
undetectable		 3jx6A-3t2nL:
20.15
3jx6B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 PHE L  62
VAL L 106
ARG L  61
VAL L  19
 None
 1.31A 3jx6A-3t2nL:
undetectable
3jx6B-3t2nL:
undetectable		 3jx6A-3t2nL:
20.15
3jx6B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 6 GLY A 354
GLN A 177
ILE A 374
VAL A 375
 None
 1.13A 3kvvD-3t2nA:
undetectable		 3kvvD-3t2nA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		3 / 3 VAL A  85
SER A  89
LEU A  76
 None
 0.69A 3n8xA-3t2nA:
undetectable		 3n8xA-3t2nA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.83A 3nljA-3t2nL:
undetectable
3nljB-3t2nL:
undetectable		 3nljA-3t2nL:
20.15
3nljB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.83A 3nljA-3t2nL:
undetectable
3nljB-3t2nL:
undetectable		 3nljA-3t2nL:
20.15
3nljB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.85A 3nlpA-3t2nL:
undetectable
3nlpB-3t2nL:
undetectable		 3nlpA-3t2nL:
20.15
3nlpB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.88A 3nlpA-3t2nL:
undetectable
3nlpB-3t2nL:
undetectable		 3nlpA-3t2nL:
20.15
3nlpB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.83A 3nlqA-3t2nL:
undetectable
3nlqB-3t2nL:
undetectable		 3nlqA-3t2nL:
20.15
3nlqB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.85A 3nlqA-3t2nL:
undetectable
3nlqB-3t2nL:
undetectable		 3nlqA-3t2nL:
20.15
3nlqB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.86A 3nlrA-3t2nL:
undetectable
3nlrB-3t2nL:
undetectable		 3nlrA-3t2nL:
20.15
3nlrB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.87A 3nlrA-3t2nL:
undetectable
3nlrB-3t2nL:
undetectable		 3nlrA-3t2nL:
20.15
3nlrB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 4 GLY A 190
GLY A 355
THR A 294
LEU A 309
 None
 0.90A 3si7C-3t2nA:
undetectable
3si7D-3t2nA:
undetectable		 3si7C-3t2nA:
19.54
3si7D-3t2nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 7 ARG A 210
VAL A 178
GLY A 189
VAL A 237
 None
 0.84A 3ufnB-3t2nA:
undetectable		 3ufnB-3t2nA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 GLN L   6
PHE L  98
GLY L  99
GLY L  49
 None
 0.99A 3v3nB-3t2nL:
undetectable		 3v3nB-3t2nL:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 8 ILE A 258
ASP A 257
ILE A 374
GLY A 190
 None
 0.81A 4acaC-3t2nA:
undetectable		 4acaC-3t2nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 8 ILE A 258
ASP A 257
ILE A 374
GLY A 190
 None
 0.77A 4acbC-3t2nA:
undetectable		 4acbC-3t2nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.91A 4cx3A-3t2nL:
undetectable
4cx3B-3t2nL:
undetectable		 4cx3A-3t2nL:
20.15
4cx3B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.88A 4cx3A-3t2nL:
undetectable
4cx3B-3t2nL:
undetectable		 4cx3A-3t2nL:
20.15
4cx3B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.90A 4cx4A-3t2nL:
undetectable
4cx4B-3t2nL:
undetectable		 4cx4A-3t2nL:
20.15
4cx4B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.89A 4cx4A-3t2nL:
undetectable
4cx4B-3t2nL:
undetectable		 4cx4A-3t2nL:
20.15
4cx4B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		3 / 3 SER A  89
MET A  93
ASP A  67
 None
 0.98A 4mm4B-3t2nA:
undetectable		 4mm4B-3t2nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		3 / 3 PHE A 401
THR A 391
LEU A 193
 None
 0.77A 4qztA-3t2nA:
undetectable		 4qztA-3t2nA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		5 / 9 PRO A 356
LEU A 180
ILE A 374
LEU A 199
THR A 200
 None
 1.25A 4x3mB-3t2nA:
undetectable		 4x3mB-3t2nA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 VAL L 106
ARG L  61
VAL L  19
PHE L  62
 None
 1.42A 5addA-3t2nL:
undetectable
5addB-3t2nL:
undetectable		 5addA-3t2nL:
20.15
5addB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.81A 5addA-3t2nL:
undetectable
5addB-3t2nL:
undetectable		 5addA-3t2nL:
20.15
5addB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 VAL L 106
ARG L  61
VAL L  19
PHE L  62
 None
 1.42A 5adeA-3t2nL:
undetectable
5adeB-3t2nL:
undetectable		 5adeA-3t2nL:
20.15
5adeB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.79A 5adeA-3t2nL:
undetectable
5adeB-3t2nL:
undetectable		 5adeA-3t2nL:
20.15
5adeB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 LEU L 133
ALA L 131
LEU L 179
THR L 182
 None
 1.07A 5bojA-3t2nL:
3.8		 5bojA-3t2nL:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.87A 5g0pA-3t2nL:
undetectable
5g0pB-3t2nL:
undetectable		 5g0pA-3t2nL:
20.15
5g0pB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLU L  83
VAL L 106
ARG L  61
VAL L  19
 None
 0.90A 5g0pA-3t2nL:
undetectable
5g0pB-3t2nL:
undetectable		 5g0pA-3t2nL:
20.15
5g0pB-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		5 / 12 VAL A 120
ASP A 121
GLU A 122
LEU A  63
SER A  79
 None
 1.40A 5hnxB-3t2nA:
undetectable		 5hnxB-3t2nA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 LEU L 133
ALA L 131
LEU L 179
THR L 182
 None
 1.03A 5l4iA-3t2nL:
undetectable		 5l4iA-3t2nL:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 8 GLY A  94
LEU A 278
CYH A 372
SER A 394
 None
 0.76A 5xu8A-3t2nA:
undetectable		 5xu8A-3t2nA:
21.55