SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 11 CYH A 185
LEU A 181
THR A 179
ILE A 191
VAL A 190
 None
 1.24A 1pkvA-3t32A:
undetectable
1pkvB-3t32A:
undetectable		 1pkvA-3t32A:
14.68
1pkvB-3t32A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 SER A 255
VAL A  86
ILE A 244
ILE A 223
PHE A 102
 None
 0.98A 1qhsA-3t32A:
undetectable		 1qhsA-3t32A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		4 / 7 VAL A 157
VAL A 123
TYR A 352
ARG A 221
 None
 1.12A 1t46A-3t32A:
undetectable		 1t46A-3t32A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 11 VAL A  92
LEU A  95
TYR A 116
CYH A 163
ASP A 195
 LLP  A 230 ( 3.8A)
None
LLP  A 230 ( 3.8A)
LLP  A 230 ( 3.5A)
LLP  A 230 ( 3.0A)
 0.84A 2z9xB-3t32A:
22.6		 2z9xB-3t32A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 PHE A 253
ALA A 194
VAL A  86
THR A 103
VAL A 109
 None
 1.14A 3czhB-3t32A:
undetectable		 3czhB-3t32A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 9 ARG A 334
LEU A 338
ILE A 302
VAL A 346
ILE A 344
 None
 1.10A 3d1yB-3t32A:
undetectable		 3d1yB-3t32A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 ALA A 235
SER A 317
ILE A 201
ARG A 288
LEU A 284
 None
 1.42A 3ia4A-3t32A:
undetectable		 3ia4A-3t32A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 TYR A 116
HIS A 198
SER A 317
ILE A 115
LEU A 135
 LLP  A 230 ( 3.8A)
LLP  A 230 ( 3.9A)
None
None
None
 1.19A 3lcvB-3t32A:
undetectable		 3lcvB-3t32A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		4 / 6 GLN A 274
PHE A  87
PRO A  60
LEU A 265
 None
 1.38A 3tgvD-3t32A:
undetectable		 3tgvD-3t32A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		4 / 7 LEU A 110
SER A 133
GLU A 150
HIS A 148
 None
 1.23A 4aq7A-3t32A:
undetectable		 4aq7A-3t32A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		4 / 6 ASP A 332
SER A 330
ARG A 334
GLU A 350
 None
 1.00A 4eysA-3t32A:
undetectable		 4eysA-3t32A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_2
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		4 / 5 TRP A 283
SER A 317
MET A  34
ASN A 233
 None
None
LLP  A 230 ( 4.2A)
None
 1.19A 4j03A-3t32A:
1.4		 4j03A-3t32A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		3 / 3 ARG A 377
LYS A 343
LYS A  24
 None
 1.25A 4k50A-3t32A:
undetectable		 4k50A-3t32A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		3 / 3 ARG A 377
LYS A 343
LYS A  24
 None
 1.22A 4k50E-3t32A:
undetectable		 4k50E-3t32A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		3 / 3 ARG A 377
LYS A 343
LYS A  24
 None
 1.26A 4k50I-3t32A:
undetectable		 4k50I-3t32A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 ASN A 294
LEU A 375
CYH A 299
ALA A 298
GLY A 170
 None
 1.19A 4n09A-3t32A:
undetectable		 4n09A-3t32A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 LEU A 378
ALA A 298
ILE A 344
ILE A  27
VAL A 370
 None
 0.79A 4nkvB-3t32A:
undetectable		 4nkvB-3t32A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 LEU A 378
ALA A 298
ILE A 344
ILE A  27
VAL A 370
 None
 0.78A 4nkvD-3t32A:
undetectable		 4nkvD-3t32A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		6 / 12 PHE A 120
GLY A 353
ILE A 115
LEU A 130
LEU A 110
ILE A  99
 None
 1.50A 4pd4C-3t32A:
undetectable		 4pd4C-3t32A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 9 ARG A 334
LEU A 338
ILE A 302
VAL A 346
ILE A 344
 None
 1.11A 5kr2D-3t32A:
undetectable		 5kr2D-3t32A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 9 ILE A 223
ALA A 194
ILE A  91
ALA A  94
LEU A  95
 None
None
LLP  A 230 ( 4.2A)
None
None
 1.01A 5mvmA-3t32A:
undetectable
5mvmE-3t32A:
undetectable		 5mvmA-3t32A:
12.37
5mvmE-3t32A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 10 ILE A  91
ALA A  94
LEU A  95
ILE A 223
ALA A 194
 LLP  A 230 ( 4.2A)
None
None
None
None
 1.04A 5mvmD-3t32A:
undetectable
5mvmE-3t32A:
undetectable		 5mvmD-3t32A:
12.37
5mvmE-3t32A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 ILE A  85
ALA A  94
THR A  97
ALA A 252
GLU A 247
 None
 1.10A 5vceA-3t32A:
undetectable		 5vceA-3t32A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		4 / 8 GLN A 274
GLY A  65
ILE A 241
GLN A 257
 None
 0.74A 5vlmH-3t32A:
undetectable		 5vlmH-3t32A:
19.53