SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 HIS A 282
ALA A 284
GLY A 239
GLY A 279
LEU A 274
 None
 1.11A 1x1aA-3t34A:
undetectable		 1x1aA-3t34A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 GLY A  56
ILE A  37
LEU A 178
LEU A  74
LEU A  76
 None
 1.01A 3cs8A-3t34A:
undetectable		 3cs8A-3t34A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		4 / 6 SER A  45
SER A  48
GLY A 145
GLY A  41
 GDP  A1000 (-3.9A)
MG  A1002 ( 2.3A)
ALF  A1001 (-3.5A)
None
 0.73A 3rxfA-3t34A:
undetectable		 3rxfA-3t34A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 ILE A   5
VAL A 238
ILE A 176
LEU A 178
VAL A 209
 None
 1.19A 3w68C-3t34A:
undetectable		 3w68C-3t34A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		4 / 8 VAL A 166
CYH A 175
VAL A  40
ILE A 141
 None
 0.89A 4aftD-3t34A:
undetectable
4aftE-3t34A:
undetectable		 4aftD-3t34A:
20.05
4aftE-3t34A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 VAL A  50
SER A 280
VAL A 238
GLY A 208
LEU A 178
 None
 1.16A 4coxB-3t34A:
undetectable		 4coxB-3t34A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 VAL A  50
SER A 280
VAL A 238
GLY A 208
LEU A 178
 None
 1.16A 4coxC-3t34A:
undetectable		 4coxC-3t34A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 VAL A  50
SER A 280
VAL A 238
GLY A 208
LEU A 178
 None
 1.16A 4coxD-3t34A:
undetectable		 4coxD-3t34A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		3 / 3 ARG A 167
LYS A 160
GLU A 163
 None
 0.63A 5d0yA-3t34A:
undetectable		 5d0yA-3t34A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 11 ILE A 176
LEU A 283
PHE A 207
ALA A 179
VAL A 294
 None
 1.23A 5ji0A-3t34A:
undetectable		 5ji0A-3t34A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 ASP A 142
GLU A  52
SER A  53
ARG A 243
GLY A  63
 MG  A1002 ( 3.9A)
None
None
None
GDP  A1000 ( 3.5A)
 1.23A 5m50B-3t34A:
3.0		 5m50B-3t34A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 ASP A 142
GLU A  52
SER A  53
ARG A 243
GLY A  63
 MG  A1002 ( 3.9A)
None
None
None
GDP  A1000 ( 3.5A)
 1.24A 5m50E-3t34A:
3.9		 5m50E-3t34A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 TYR A 169
LEU A 146
GLY A 145
VAL A 124
ASP A 142
 None
None
ALF  A1001 (-3.5A)
None
MG  A1002 ( 3.9A)
 1.38A 6bxlB-3t34A:
undetectable		 6bxlB-3t34A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		4 / 4 PRO A  61
LEU A  72
VAL A 103
ARG A 104
 None
 1.47A 6fgdA-3t34A:
2.1		 6fgdA-3t34A:
23.92