SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 ALA A 103
GLU A 128
LEU A 278
ILE A 244
HIS A 245
 None
 1.42A 1a52A-3t3oA:
undetectable		 1a52A-3t3oA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 ALA A 103
GLU A 128
LEU A 278
ILE A 244
HIS A 245
 None
 1.43A 1a52B-3t3oA:
undetectable		 1a52B-3t3oA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 5 HIS A 376
HIS A  75
HIS A  80
HIS A 398
ASP A 204
 None
ZN  A 600 (-4.8A)
ZN  A 600 (-3.6A)
ZN  A 600 (-3.6A)
None
 1.34A 1e9yB-3t3oA:
2.3		 1e9yB-3t3oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 9 ALA A 103
GLU A 128
LEU A 278
ILE A 244
HIS A 245
 None
 1.46A 1ereA-3t3oA:
undetectable		 1ereA-3t3oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 9 ALA A 103
GLU A 128
LEU A 278
ILE A 244
HIS A 245
 None
 1.47A 1ereB-3t3oA:
undetectable		 1ereB-3t3oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 9 ALA A 103
GLU A 128
LEU A 278
ILE A 244
HIS A 245
 None
 1.47A 1ereC-3t3oA:
undetectable		 1ereC-3t3oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 9 ALA A 103
GLU A 128
LEU A 278
ILE A 244
HIS A 245
 None
 1.47A 1ereD-3t3oA:
undetectable		 1ereD-3t3oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 6 HIS A  80
HIS A 150
HIS A 376
HIS A 398
ASP A  79
 ZN  A 600 (-3.6A)
None
None
ZN  A 600 (-3.6A)
ZN  A 600 (-2.5A)
 1.30A 1fweC-3t3oA:
undetectable		 1fweC-3t3oA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 6 HIS A 376
HIS A  75
HIS A  80
HIS A 398
ASP A 204
 None
ZN  A 600 (-4.8A)
ZN  A 600 (-3.6A)
ZN  A 600 (-3.6A)
None
 1.29A 1fweC-3t3oA:
undetectable		 1fweC-3t3oA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 ARG A 266
VAL A 450
ILE A  55
GLY A  83
GLY A  82
 None
 0.97A 1k6cA-3t3oA:
undetectable		 1k6cA-3t3oA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 PHE A 407
THR A 170
ILE A  21
GLY A 399
ALA A 208
 None
 1.05A 1nv8B-3t3oA:
3.2		 1nv8B-3t3oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		3 / 3 ASP A  79
HIS A 150
ASP A 204
 ZN  A 600 (-2.5A)
None
None
 0.86A 1nw5A-3t3oA:
undetectable		 1nw5A-3t3oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 LEU A  73
ALA A 103
LEU A 126
ARG A 111
LEU A 145
 None
 1.48A 1pcgB-3t3oA:
undetectable		 1pcgB-3t3oA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 PHE A 407
THR A 170
ILE A  21
GLY A 399
ALA A 208
 None
 0.99A 1sg9B-3t3oA:
undetectable		 1sg9B-3t3oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 11 LEU A 201
GLY A 194
ALA A 193
THR A 170
VAL A 168
 None
 0.74A 1t7jA-3t3oA:
undetectable		 1t7jA-3t3oA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.82A 1usqA-3t3oA:
undetectable		 1usqA-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.82A 1usqB-3t3oA:
undetectable		 1usqB-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.81A 1usqC-3t3oA:
undetectable		 1usqC-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.84A 1usqD-3t3oA:
undetectable		 1usqD-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.84A 1usqE-3t3oA:
undetectable		 1usqE-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.82A 1usqF-3t3oA:
undetectable		 1usqF-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 PHE A 407
THR A 170
ILE A  21
GLY A 399
ALA A 208
 None
 0.92A 1vq1B-3t3oA:
undetectable		 1vq1B-3t3oA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 HIS A 150
ASP A  79
ILE A 152
SER A 272
PHE A 271
 None
ZN  A 600 (-2.5A)
None
None
None
 1.18A 1xoqA-3t3oA:
undetectable		 1xoqA-3t3oA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 HIS A 150
ASP A  79
ILE A 152
SER A 272
PHE A 271
 None
ZN  A 600 (-2.5A)
None
None
None
 1.22A 1xoqB-3t3oA:
undetectable		 1xoqB-3t3oA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 ILE A 152
GLY A  76
LEU A 107
LEU A 109
ILE A 129
 None
 1.12A 1zq9A-3t3oA:
2.9		 1zq9A-3t3oA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 11 LEU A 395
ILE A  12
HIS A  80
ASP A 172
GLY A 171
 None
None
ZN  A 600 (-3.6A)
ZN  A 600 (-2.4A)
None
 1.21A 1zz1A-3t3oA:
undetectable		 1zz1A-3t3oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 LEU A 107
GLY A 108
LEU A 109
LEU A 110
ILE A  81
 None
 1.07A 2f8dA-3t3oA:
undetectable		 2f8dA-3t3oA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 LEU A 107
GLY A 108
LEU A 109
LEU A 110
ILE A  81
 None
 1.06A 2f8dB-3t3oA:
undetectable		 2f8dB-3t3oA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.85A 2jkjA-3t3oA:
undetectable		 2jkjA-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.85A 2jkjB-3t3oA:
undetectable		 2jkjB-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.85A 2jkjC-3t3oA:
undetectable		 2jkjC-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.84A 2jkjE-3t3oA:
undetectable		 2jkjE-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.85A 2jklA-3t3oA:
undetectable		 2jklA-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.86A 2jklB-3t3oA:
undetectable		 2jklB-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.83A 2jklC-3t3oA:
undetectable		 2jklC-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.87A 2jklD-3t3oA:
undetectable		 2jklD-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.85A 2jklE-3t3oA:
undetectable		 2jklE-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.86A 2jklF-3t3oA:
undetectable		 2jklF-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 ALA A 203
ASP A 204
GLY A 157
VAL A 158
VAL A 198
 None
 1.23A 2o4lA-3t3oA:
undetectable		 2o4lA-3t3oA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 11 ASP A  79
HIS A  80
HIS A 150
ASP A 172
HIS A 398
 ZN  A 600 (-2.5A)
ZN  A 600 (-3.6A)
None
ZN  A 600 (-2.4A)
ZN  A 600 (-3.6A)
 0.87A 2q0jB-3t3oA:
10.6		 2q0jB-3t3oA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 ARG A 266
VAL A 450
ILE A  55
GLY A  83
GLY A  82
 None
 1.02A 2r5pA-3t3oA:
undetectable		 2r5pA-3t3oA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 ARG A 266
VAL A 450
ILE A  55
GLY A  83
GLY A  82
 None
 1.02A 2r5pC-3t3oA:
undetectable		 2r5pC-3t3oA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 LEU A 448
LEU A  41
GLY A  40
TRP A  71
VAL A  36
 None
 1.13A 2w8yA-3t3oA:
undetectable		 2w8yA-3t3oA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 HIS A 150
ASP A 204
GLU A 400
PRO A 343
ILE A  21
 None
 1.41A 3b7pC-3t3oA:
2.3		 3b7pC-3t3oA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 VAL A 159
THR A  74
THR A 142
ARG A 161
 None
 1.26A 3bjwG-3t3oA:
undetectable		 3bjwG-3t3oA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 VAL A 159
VAL A 158
THR A 389
THR A 142
 None
 1.25A 3bjwG-3t3oA:
undetectable		 3bjwG-3t3oA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 VAL A 159
VAL A 158
THR A 389
THR A 142
 None
 1.23A 3bjwC-3t3oA:
undetectable		 3bjwC-3t3oA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 HIS A 150
HIS A 376
HIS A 398
ASP A  79
 None
None
ZN  A 600 (-3.6A)
ZN  A 600 (-2.5A)
 1.05A 3c0zA-3t3oA:
undetectable		 3c0zA-3t3oA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 6 HIS A 150
HIS A 376
HIS A 398
ASP A  79
 None
None
ZN  A 600 (-3.6A)
ZN  A 600 (-2.5A)
 1.11A 3c0zC-3t3oA:
undetectable		 3c0zC-3t3oA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 GLY A  40
GLY A  82
GLY A  76
ASP A  38
ILE A  25
 None
 1.05A 3eluA-3t3oA:
undetectable		 3eluA-3t3oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 PRO A 391
VAL A 198
THR A  74
GLY A 157
 None
 1.21A 3elzB-3t3oA:
undetectable		 3elzB-3t3oA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 GLY A  40
GLY A  82
GLY A  76
ASP A  38
ILE A  25
 None
 1.07A 3embA-3t3oA:
undetectable		 3embA-3t3oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 GLY A  40
GLY A  82
GLY A  76
ASP A  38
ILE A  25
 None
 1.04A 3gczA-3t3oA:
undetectable		 3gczA-3t3oA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 PRO A  49
GLY A  47
VAL A 450
ASP A 451
LEU A  41
 None
 1.10A 3m6vA-3t3oA:
undetectable		 3m6vA-3t3oA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 PRO A  49
GLY A  47
VAL A 450
ASP A 451
LEU A  41
 None
 1.09A 3m6vB-3t3oA:
undetectable		 3m6vB-3t3oA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 LEU A 356
LEU A 316
LEU A 337
VAL A 371
LEU A 224
 None
 1.12A 3r9cA-3t3oA:
undetectable		 3r9cA-3t3oA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 7 ASP A 172
HIS A 376
ILE A  21
HIS A 398
 ZN  A 600 (-2.4A)
None
None
ZN  A 600 (-3.6A)
 1.11A 3t01A-3t3oA:
2.2		 3t01A-3t3oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 11 LEU A  61
VAL A  58
SER A  96
LEU A  84
PHE A 124
 None
 1.19A 3tbgA-3t3oA:
undetectable		 3tbgA-3t3oA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		3 / 3 HIS A 150
HIS A  75
ILE A 152
 None
ZN  A 600 (-4.8A)
None
 0.78A 3u52A-3t3oA:
undetectable
3u52C-3t3oA:
undetectable		 3u52A-3t3oA:
20.50
3u52C-3t3oA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 HIS A  75
HIS A  80
HIS A 398
ASP A 204
GLY A 171
 ZN  A 600 (-4.8A)
ZN  A 600 (-3.6A)
ZN  A 600 (-3.6A)
None
None
 1.32A 4bz6A-3t3oA:
undetectable		 4bz6A-3t3oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 5 HIS A 376
HIS A  75
HIS A  80
HIS A 398
ASP A 204
 None
ZN  A 600 (-4.8A)
ZN  A 600 (-3.6A)
ZN  A 600 (-3.6A)
None
 1.28A 4h9mA-3t3oA:
2.6		 4h9mA-3t3oA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 ILE A 353
GLY A 307
GLY A 310
ALA A 320
ALA A 305
 None
 1.12A 4kicB-3t3oA:
undetectable		 4kicB-3t3oA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		3 / 3 ASP A 204
VAL A 168
ASN A  24
 None
None
ZN  A 600 ( 4.7A)
 0.73A 4lmnA-3t3oA:
undetectable		 4lmnA-3t3oA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 THR A 162
THR A  26
LEU A 395
LEU A 200
 None
 1.12A 4lvcB-3t3oA:
undetectable		 4lvcB-3t3oA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 HIS A  80
GLY A  17
ASP A 172
ASP A 204
GLY A 171
 ZN  A 600 (-3.6A)
None
ZN  A 600 (-2.4A)
None
None
 1.36A 4qa0A-3t3oA:
undetectable		 4qa0A-3t3oA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 TYR A 430
HIS A  80
ASP A 172
ASP A 204
GLY A 171
 None
ZN  A 600 (-3.6A)
ZN  A 600 (-2.4A)
None
None
 1.24A 4qa0A-3t3oA:
undetectable		 4qa0A-3t3oA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 11 HIS A  75
ASP A  79
HIS A  80
HIS A 150
HIS A 398
 ZN  A 600 (-4.8A)
ZN  A 600 (-2.5A)
ZN  A 600 (-3.6A)
None
ZN  A 600 (-3.6A)
 0.55A 5ayaA-3t3oA:
11.0		 5ayaA-3t3oA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 LEU A  73
ALA A 103
LEU A 126
ARG A 111
LEU A 145
 None
 1.47A 5dxeB-3t3oA:
undetectable		 5dxeB-3t3oA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 HIS A  75
HIS A  80
HIS A 398
ASP A 204
GLY A 171
 ZN  A 600 (-4.8A)
ZN  A 600 (-3.6A)
ZN  A 600 (-3.6A)
None
None
 1.29A 5eenA-3t3oA:
undetectable		 5eenA-3t3oA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 GLY A  40
GLY A  82
GLY A  76
ASP A  38
ILE A  25
 None
 1.05A 5ehiC-3t3oA:
undetectable		 5ehiC-3t3oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 LEU A  73
ALA A 103
LEU A 126
ARG A 111
LEU A 145
 None
 1.48A 5hyrA-3t3oA:
undetectable		 5hyrA-3t3oA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 LEU A 145
PHE A 146
LEU A 143
PHE A  35
 None
 1.26A 5iy5P-3t3oA:
undetectable
5iy5W-3t3oA:
undetectable		 5iy5P-3t3oA:
16.93
5iy5W-3t3oA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 TYR A 430
LYS A 439
GLU A 442
GLY A 427
 None
 0.77A 5jhdJ-3t3oA:
undetectable		 5jhdJ-3t3oA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		3 / 3 HIS A 150
ASP A 204
HIS A 376
 None
 0.87A 5n1tW-3t3oA:
undetectable		 5n1tW-3t3oA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 GLU A 292
LEU A 304
ALA A 262
ARG A 266
ARG A 286
 None
 1.13A 5nd3B-3t3oA:
undetectable		 5nd3B-3t3oA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 8 ASP A 172
HIS A 150
HIS A  75
HIS A 398
 ZN  A 600 (-2.4A)
None
ZN  A 600 (-4.8A)
ZN  A 600 (-3.6A)
 0.92A 5nekD-3t3oA:
undetectable		 5nekD-3t3oA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 HIS A  75
HIS A  80
HIS A 150
ASP A 172
HIS A 376
 ZN  A 600 (-4.8A)
ZN  A 600 (-3.6A)
None
ZN  A 600 (-2.4A)
None
 0.39A 5nzwA-3t3oA:
8.7		 5nzwA-3t3oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 10 HIS A 150
HIS A  75
HIS A 376
ASP A 172
HIS A 398
 None
ZN  A 600 (-4.8A)
None
ZN  A 600 (-2.4A)
ZN  A 600 (-3.6A)
 0.93A 5nzwA-3t3oA:
8.7		 5nzwA-3t3oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		3 / 3 HIS A  80
ASP A 172
HIS A 398
 ZN  A 600 (-3.6A)
ZN  A 600 (-2.4A)
ZN  A 600 (-3.6A)
 0.70A 5oexA-3t3oA:
undetectable		 5oexA-3t3oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		3 / 3 HIS A  80
ASP A 172
HIS A 398
 ZN  A 600 (-3.6A)
ZN  A 600 (-2.4A)
ZN  A 600 (-3.6A)
 0.74A 5oexB-3t3oA:
undetectable		 5oexB-3t3oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		3 / 3 HIS A  80
ASP A 172
HIS A 398
 ZN  A 600 (-3.6A)
ZN  A 600 (-2.4A)
ZN  A 600 (-3.6A)
 0.74A 5oexC-3t3oA:
undetectable		 5oexC-3t3oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		3 / 3 HIS A  80
ASP A 172
HIS A 398
 ZN  A 600 (-3.6A)
ZN  A 600 (-2.4A)
ZN  A 600 (-3.6A)
 0.74A 5oexD-3t3oA:
undetectable		 5oexD-3t3oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 GLN A 404
LEU A 395
HIS A 169
ASN A 426
HIS A  75
 None
None
None
None
ZN  A 600 (-4.8A)
 1.49A 5uhcC-3t3oA:
2.3		 5uhcC-3t3oA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 LEU A 145
PHE A 146
LEU A 143
PHE A  35
 None
 1.24A 5xdxC-3t3oA:
undetectable
5xdxJ-3t3oA:
undetectable		 5xdxC-3t3oA:
17.11
5xdxJ-3t3oA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		4 / 5 LEU A 145
PHE A 146
LEU A 143
PHE A  35
 None
 1.27A 5xdxP-3t3oA:
undetectable
5xdxW-3t3oA:
undetectable		 5xdxP-3t3oA:
17.11
5xdxW-3t3oA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 GLN A 404
ASP A 204
ASN A  24
GLY A  17
HIS A 398
 None
None
ZN  A 600 ( 4.7A)
None
ZN  A 600 (-3.6A)
 1.46A 6exiA-3t3oA:
undetectable		 6exiA-3t3oA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 GLN A 404
ASP A 204
ASN A  24
GLY A  17
HIS A 398
 None
None
ZN  A 600 ( 4.7A)
None
ZN  A 600 (-3.6A)
 1.46A 6exiD-3t3oA:
3.2		 6exiD-3t3oA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 3t3o METAL DEPENDENT
HYDROLASE
(Thermus
thermophilus) 		5 / 12 LEU A  54
VAL A  51
PRO A  44
THR A 306
GLY A 307
 None
 1.41A 6mn8A-3t3oA:
undetectable		 6mn8A-3t3oA:
21.73