SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3t3w ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 VAL A 159
TRP A 134
HIS A 164
LEU A 177
 None
 0.80A 1pk2A-3t3wA:
undetectable		 1pk2A-3t3wA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3t3w ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 4 LEU A  67
VAL A  66
ILE A  65
TRP A 110
 None
 1.35A 1s9qB-3t3wA:
undetectable		 1s9qB-3t3wA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t3w ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 THR A 191
GLU A 167
HIS A 162
 None
 0.69A 3g1uB-3t3wA:
undetectable		 3g1uB-3t3wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3t3w ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 VAL A 188
VAL A 194
ILE A 139
LEU A 130
 None
 0.98A 4l1wB-3t3wA:
1.8		 4l1wB-3t3wA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3t3w ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LYS A 115
ILE A  65
ILE A  30
 None
 0.67A 4y0qA-3t3wA:
undetectable		 4y0qA-3t3wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3t3w ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLN A 190
ALA A 141
VAL A 197
LEU A 130
ILE A 176
 None
 1.24A 5hv1A-3t3wA:
undetectable		 5hv1A-3t3wA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3t3w ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ILE A 139
ALA A 119
PHE A 147
GLY A 192
VAL A 188
 None
None
None
TRS  A 302 ( 4.3A)
None
 0.96A 5i73A-3t3wA:
undetectable		 5i73A-3t3wA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3t3w ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 4 GLY A 128
LEU A 131
VAL A 159
GLU A 160
 None
None
None
ZN  A 301 (-3.0A)
 1.23A 5yw0A-3t3wA:
undetectable		 5yw0A-3t3wA:
19.51