SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3t43 HIV EPITOPE-SCAFFOLD
4E10_1XIZA_S0_006_C
(synthetic
construct) 		4 / 6 LEU A  11
ILE A 110
TRP A 105
VAL A  85
 None
 1.11A 1db1A-3t43A:
undetectable		 1db1A-3t43A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3t43 HIV EPITOPE-SCAFFOLD
4E10_1XIZA_S0_006_C
(synthetic
construct) 		5 / 12 SER A 130
LEU A  91
GLY A  65
VAL A  47
ALA A  48
 None
 1.13A 1tsnA-3t43A:
undetectable		 1tsnA-3t43A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3t43 HIV EPITOPE-SCAFFOLD
4E10_1XIZA_S0_006_C
(synthetic
construct) 		5 / 10 ILE A 127
VAL A 151
GLY A  65
VAL A 109
LEU A 120
 None
 1.20A 3elzC-3t43A:
undetectable		 3elzC-3t43A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3t43 HIV EPITOPE-SCAFFOLD
4E10_1XIZA_S0_006_C
(synthetic
construct) 		4 / 5 ILE A   8
ALA A  12
HIS A  51
MET A  90
 None
 1.17A 4ac9B-3t43A:
undetectable
4ac9C-3t43A:
undetectable		 4ac9B-3t43A:
18.37
4ac9C-3t43A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3t43 HIV EPITOPE-SCAFFOLD
4E10_1XIZA_S0_006_C
(synthetic
construct) 		4 / 5 ILE A   8
ALA A  12
HIS A  51
MET A  90
 None
 1.19A 4acaB-3t43A:
undetectable
4acaC-3t43A:
undetectable		 4acaB-3t43A:
18.37
4acaC-3t43A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3t43 HIV EPITOPE-SCAFFOLD
4E10_1XIZA_S0_006_C
(synthetic
construct) 		4 / 5 VAL A  57
ASN A  95
ASP A  98
LEU A  93
 None
 1.28A 5m0iB-3t43A:
undetectable		 5m0iB-3t43A:
19.03