SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 SER A  90
VAL A 185
GLY A 187
ILE A 217
 None
 0.87A 1gtnC-3t44A:
undetectable
1gtnD-3t44A:
undetectable		 1gtnC-3t44A:
16.36
1gtnD-3t44A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 238
ASP A 237
VAL A 185
GLY A 187
ILE A  55
 None
 0.84A 1hshA-3t44A:
undetectable		 1hshA-3t44A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 140
ASP A 120
ILE A  10
GLU A 168
 None
None
None
IGP  A 300 (-3.0A)
 1.10A 1mt1A-3t44A:
undetectable
1mt1F-3t44A:
undetectable		 1mt1A-3t44A:
14.86
1mt1F-3t44A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 235
ALA A 236
ASP A 237
ILE A 217
ILE A 206
 None
 0.80A 1sdvB-3t44A:
undetectable		 1sdvB-3t44A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 235
ALA A 236
ASP A 237
GLY A 187
ILE A 206
 None
 0.85A 2fxeA-3t44A:
undetectable		 2fxeA-3t44A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 235
ALA A 236
ASP A 237
ILE A 217
ILE A 206
 None
 0.72A 2o4sB-3t44A:
undetectable		 2o4sB-3t44A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 235
ALA A 236
ASP A 237
ILE A 217
ILE A 206
 None
 0.81A 2q5kB-3t44A:
undetectable		 2q5kB-3t44A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 235
ALA A 236
ASP A 237
ILE A 217
ILE A 206
 None
 0.78A 2r5qB-3t44A:
undetectable		 2r5qB-3t44A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 235
ALA A 236
ASP A 237
ILE A 217
ILE A 206
 None
 0.78A 2r5qD-3t44A:
undetectable		 2r5qD-3t44A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 238
ASP A 237
VAL A 185
GLY A 187
ILE A  55
 None
 0.83A 2rkgA-3t44A:
undetectable		 2rkgA-3t44A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 238
ASP A 237
VAL A 185
GLY A 187
ILE A  55
 None
 0.83A 2rkgB-3t44A:
undetectable		 2rkgB-3t44A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 240
GLU A 219
ASN A 189
SER A  90
 IGP  A 300 (-4.3A)
IGP  A 300 (-3.9A)
IGP  A 300 (-3.6A)
None
 1.42A 3i9jB-3t44A:
undetectable		 3i9jB-3t44A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  47
ARG A  87
ALA A  86
GLY A 187
 None
 0.91A 3ny4A-3t44A:
undetectable		 3ny4A-3t44A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  77
ALA A  61
GLY A 249
PRO A 251
 None
 0.94A 3ny4A-3t44A:
undetectable		 3ny4A-3t44A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 238
ASP A 237
VAL A 185
GLY A 187
ILE A  55
 None
 0.79A 3s54B-3t44A:
undetectable		 3s54B-3t44A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 235
ALA A 236
ASP A 237
ILE A 206
 None
 0.61A 3t3cA-3t44A:
undetectable		 3t3cA-3t44A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  88
VAL A  43
ILE A 215
THR A 158
ILE A 217
 None
 1.10A 3vrjA-3t44A:
undetectable
3vrjC-3t44A:
undetectable		 3vrjA-3t44A:
21.81
3vrjC-3t44A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 126
ARG A 118
HIS A 134
 None
 0.92A 4fubA-3t44A:
undetectable		 4fubA-3t44A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  53
LEU A 229
ALA A 261
ASP A 257
ALA A 256
 None
 1.31A 4wnuD-3t44A:
undetectable		 4wnuD-3t44A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 238
ASP A 237
VAL A 185
GLY A 187
ILE A  55
 None
 0.82A 5e5jA-3t44A:
undetectable		 5e5jA-3t44A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 238
ASP A 237
VAL A 185
GLY A 187
ILE A  55
 None
 0.80A 5e5kA-3t44A:
undetectable		 5e5kA-3t44A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 235
ALA A 236
ASP A 237
ILE A 206
 None
 0.64A 5kqyB-3t44A:
undetectable		 5kqyB-3t44A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 235
ALA A 236
ASP A 237
ILE A 206
 None
 0.67A 5kr1B-3t44A:
undetectable		 5kr1B-3t44A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 238
ASP A 237
VAL A 185
GLY A 187
ILE A  55
 None
 0.83A 5t8hA-3t44A:
undetectable		 5t8hA-3t44A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 183
LEU A 179
LEU A 210
VAL A 169
ILE A 206
 None
 1.14A 5v02B-3t44A:
undetectable
5v02R-3t44A:
undetectable		 5v02B-3t44A:
17.23
5v02R-3t44A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 142
PHE A 121
ARG A 191
THR A 195
 None
IGP  A 300 (-4.3A)
BE2  A 273 (-4.5A)
None
 1.23A 5z84N-3t44A:
undetectable
5z84W-3t44A:
undetectable		 5z84N-3t44A:
19.69
5z84W-3t44A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 235
ALA A 236
ASP A 237
ILE A 217
ILE A 206
 None
 0.71A 6dj1B-3t44A:
undetectable		 6dj1B-3t44A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 235
ALA A 236
ASP A 237
ILE A 217
ILE A 206
 None
 0.71A 6dj2B-3t44A:
undetectable		 6dj2B-3t44A:
15.12