SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		6 / 11 LEU A  85
ASP A  54
VAL A 104
GLY A  72
ILE A  75
VAL A  87
 None
 1.18A 1t7jA-3t4cA:
undetectable		 1t7jA-3t4cA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		3 / 3 TYR A  53
ARG A  81
GLN A  82
 None
 1.00A 1tw4A-3t4cA:
undetectable		 1tw4A-3t4cA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		4 / 6 LEU A 235
LEU A  16
LEU A 262
LEU A 269
 None
 0.73A 2ab2A-3t4cA:
undetectable		 2ab2A-3t4cA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		4 / 6 SER A 202
ASP A 198
SER A 180
VAL A 171
 None
 1.30A 2hdnI-3t4cA:
undetectable
2hdnJ-3t4cA:
2.2
2hdnL-3t4cA:
2.1		 2hdnI-3t4cA:
10.94
2hdnJ-3t4cA:
19.65
2hdnL-3t4cA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		5 / 9 PHE A  47
ALA A  18
TYR A  49
ALA A  33
GLY A  34
 None
 1.35A 2v7bA-3t4cA:
undetectable		 2v7bA-3t4cA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		4 / 8 ILE A  39
PRO A 243
ASN A 242
GLY A  19
 None
 0.92A 3em0B-3t4cA:
undetectable		 3em0B-3t4cA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		5 / 10 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
 None
 0.97A 3lxiA-3t4cA:
undetectable		 3lxiA-3t4cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		5 / 11 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
 None
 0.99A 3lxiB-3t4cA:
undetectable		 3lxiB-3t4cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		5 / 12 TYR A  53
TYR A  49
GLY A  77
LEU A  85
GLY A  84
 None
 1.17A 3vywC-3t4cA:
undetectable		 3vywC-3t4cA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		5 / 9 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
 None
 0.96A 4c9kA-3t4cA:
undetectable		 4c9kA-3t4cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		5 / 10 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
 None
 0.92A 4c9nB-3t4cA:
undetectable		 4c9nB-3t4cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		5 / 9 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
 None
 0.95A 4c9pA-3t4cA:
undetectable		 4c9pA-3t4cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		5 / 10 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
 None
 0.98A 4c9pB-3t4cA:
undetectable		 4c9pB-3t4cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		4 / 8 LEU A 235
GLY A 234
MET A 182
ALA A 186
 None
 0.91A 4rjdA-3t4cA:
undetectable
4rjdB-3t4cA:
undetectable		 4rjdA-3t4cA:
16.74
4rjdB-3t4cA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		4 / 6 ALA A 199
THR A 200
VAL A 203
VAL A 254
 None
 0.86A 5eckA-3t4cA:
undetectable		 5eckA-3t4cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		4 / 6 ALA A 199
THR A 200
VAL A 203
VAL A 254
 None
 0.92A 5eckD-3t4cA:
undetectable		 5eckD-3t4cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1
(Burkholderia
ambifaria) 		4 / 8 ALA A 199
THR A 200
VAL A 203
VAL A 254
 None
 0.83A 5ecnD-3t4cA:
undetectable		 5ecnD-3t4cA:
16.81