SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		3 / 3 ARG A 268
ARG A 263
ARG A 383
 None
 0.96A 1l7fA-3t4jA:
undetectable		 1l7fA-3t4jA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		3 / 3 ARG A 268
ARG A 263
ARG A 383
 None
 0.96A 1l7hA-3t4jA:
undetectable		 1l7hA-3t4jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		4 / 7 VAL A 241
LEU A 251
GLN A 181
PHE A 184
 None
ZIP  A 400 (-4.7A)
None
None
 1.04A 3qeoB-3t4jA:
undetectable		 3qeoB-3t4jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		5 / 12 PHE A 153
ASN A 158
GLY A 379
ALA A 322
GLY A 321
 None
None
None
ZIP  A 400 (-3.5A)
None
 1.24A 3v3oB-3t4jA:
undetectable		 3v3oB-3t4jA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		5 / 11 PHE A 153
ASN A 158
GLY A 379
ALA A 322
GLY A 321
 None
None
None
ZIP  A 400 (-3.5A)
None
 1.15A 4a6nA-3t4jA:
undetectable		 4a6nA-3t4jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		3 / 3 ASP A 227
ARG A 235
PRO A 233
 None
 1.03A 4wanC-3t4jA:
undetectable		 4wanC-3t4jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		4 / 6 ARG A 134
ARG A 390
ASP A 367
VAL A 139
 None
 1.07A 4xqeA-3t4jA:
undetectable		 4xqeA-3t4jA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		4 / 6 ARG A 134
ARG A 390
ASP A 367
VAL A 139
 None
 1.12A 4xqeB-3t4jA:
undetectable		 4xqeB-3t4jA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		4 / 8 ARG A 134
ARG A 390
ASP A 367
VAL A 139
 None
 1.11A 4xqgA-3t4jA:
undetectable		 4xqgA-3t4jA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		4 / 8 ARG A 134
ARG A 390
ASP A 367
VAL A 139
 None
 1.10A 4xqgB-3t4jA:
undetectable		 4xqgB-3t4jA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		5 / 12 ALA A 204
PHE A 184
THR A 188
LEU A 163
ARG A 195
 ZIP  A 400 ( 4.1A)
None
None
None
None
 1.18A 4z7fC-3t4jA:
undetectable		 4z7fC-3t4jA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3t4j HISTIDINE KINASE 4
(Arabidopsis
thaliana) 		4 / 5 ARG A 228
MET A 226
THR A 225
LEU A 254
 None
 1.35A 5w97J-3t4jA:
undetectable		 5w97J-3t4jA:
13.38