SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Bacillus
anthracis) 		4 / 6 PHE A 138
ASN A  88
ILE A 114
GLY A 117
 None
 1.02A 1oniD-3t4xA:
undetectable
1oniF-3t4xA:
undetectable		 1oniD-3t4xA:
24.70
1oniF-3t4xA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Bacillus
anthracis) 		5 / 11 GLY A 117
THR A 121
VAL A 179
ILE A 137
VAL A 136
 None
 0.92A 1phgA-3t4xA:
undetectable		 1phgA-3t4xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Bacillus
anthracis) 		4 / 6 LEU A   5
VAL A  44
VAL A  12
ILE A  51
 None
 1.15A 2hyyB-3t4xA:
undetectable		 2hyyB-3t4xA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Bacillus
anthracis) 		5 / 8 ILE A  19
ILE A  23
ILE A  36
ARG A 135
ALA A  10
 None
 1.43A 2nniA-3t4xA:
undetectable		 2nniA-3t4xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Bacillus
anthracis) 		5 / 12 GLY A  14
GLY A  38
ARG A  39
ASN A 113
THR A  47
 None
 1.22A 2vdvE-3t4xA:
6.3		 2vdvE-3t4xA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Bacillus
anthracis) 		5 / 11 GLY A  14
GLY A  38
ARG A  39
ASN A 113
THR A  47
 None
 1.22A 2vdvF-3t4xA:
6.3		 2vdvF-3t4xA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Bacillus
anthracis) 		4 / 5 LEU A  67
GLY A 117
GLU A 111
CYH A  73
 None
 1.21A 3aiaA-3t4xA:
1.6
3aiaB-3t4xA:
1.6		 3aiaA-3t4xA:
23.36
3aiaB-3t4xA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Bacillus
anthracis) 		4 / 6 SER A 116
GLY A  14
ASN A  37
ILE A  92
 None
 1.14A 5j4nA-3t4xA:
undetectable		 5j4nA-3t4xA:
20.47