SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 212
ALA A  81
GLY A  73
TYR A  72
PHE A  67
 None
 1.28A 1brpA-3t5bA:
undetectable		 1brpA-3t5bA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 6 SER A 218
GLY A 249
THR A 214
ILE A 276
 None
 0.88A 1gtnD-3t5bA:
undetectable
1gtnE-3t5bA:
undetectable		 1gtnD-3t5bA:
11.62
1gtnE-3t5bA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 133
TYR A 107
GLU A 139
SER A 136
 None
 1.10A 1maaD-3t5bA:
2.1		 1maaD-3t5bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  78
ALA A  79
LEU A  77
LEU A  46
HIS A 178
 None
 1.42A 1y7iA-3t5bA:
undetectable		 1y7iA-3t5bA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 200
LEU A 201
ILE A 254
TRP A 237
 None
 1.22A 2hc4A-3t5bA:
undetectable		 2hc4A-3t5bA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  84
LEU A  60
ARG A  56
THR A 127
 None
 1.05A 3ag2N-3t5bA:
undetectable
3ag2W-3t5bA:
undetectable		 3ag2N-3t5bA:
22.16
3ag2W-3t5bA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  84
LEU A  60
ARG A  56
THR A 127
 None
 0.96A 3ag4N-3t5bA:
undetectable
3ag4W-3t5bA:
undetectable		 3ag4N-3t5bA:
22.16
3ag4W-3t5bA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 8 THR A 329
GLY A 300
ALA A 325
ILE A 386
 None
 0.69A 3jusA-3t5bA:
undetectable		 3jusA-3t5bA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 8 THR A 329
GLY A 300
ALA A 325
ILE A 386
 None
 0.69A 3jusA-3t5bA:
undetectable		 3jusA-3t5bA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 148
ARG A   9
THR A  13
ALA A  12
 None
 1.10A 3mbgA-3t5bA:
undetectable
3mbgB-3t5bA:
undetectable		 3mbgA-3t5bA:
15.66
3mbgB-3t5bA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 148
LEU A   8
ARG A   9
ALA A  12
 None
 1.04A 3mbgA-3t5bA:
undetectable
3mbgB-3t5bA:
undetectable		 3mbgA-3t5bA:
15.66
3mbgB-3t5bA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 264
ILE A 254
ASN A 294
PHE A 257
 None
 1.27A 3octA-3t5bA:
undetectable		 3octA-3t5bA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  73
ASN A  36
ALA A  81
LEU A   8
TRP A   6
 None
 1.15A 3p2kB-3t5bA:
undetectable		 3p2kB-3t5bA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 343
VAL A 334
VAL A 352
ARG A 337
 None
 0.99A 4m6tA-3t5bA:
undetectable		 4m6tA-3t5bA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 272
ILE A 295
TYR A 290
GLY A 248
PHE A 257
 None
 1.33A 5v5zA-3t5bA:
undetectable		 5v5zA-3t5bA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  78
LEU A  77
VAL A 181
PHE A  71
 None
 1.03A 6h7lA-3t5bA:
undetectable		 6h7lA-3t5bA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  78
LEU A  77
VAL A 181
PHE A  71
 None
 1.01A 6h7lB-3t5bA:
undetectable		 6h7lB-3t5bA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 188
ASP A 333
THR A 332
HIS A 176
 None
 1.50A 6nmfN-3t5bA:
undetectable
6nmfP-3t5bA:
undetectable		 6nmfN-3t5bA:
22.16
6nmfP-3t5bA:
18.66