SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 12 LEU A 313
LEU A 188
VAL A 187
VAL A 473
LEU A 486
 None
 1.29A 1db1A-3t5oA:
undetectable		 1db1A-3t5oA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 12 LEU A 135
GLU A 149
GLY A 139
ARG A 210
ALA A 157
 None
CD  A1001 (-3.1A)
None
None
None
 1.18A 2br4D-3t5oA:
undetectable		 2br4D-3t5oA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 12 GLY A 175
LEU A 466
LEU A 171
GLY A 181
GLU A 182
 None
 0.94A 3g2oA-3t5oA:
undetectable		 3g2oA-3t5oA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 12 GLY A 175
LEU A 466
LEU A 171
GLY A 181
GLU A 182
 None
 0.95A 3g2oB-3t5oA:
undetectable		 3g2oB-3t5oA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 10 ASP A 463
SER A 266
ILE A 295
LEU A 229
ASP A 228
 None
 1.47A 3m0wC-3t5oA:
undetectable
3m0wD-3t5oA:
undetectable
3m0wE-3t5oA:
undetectable
3m0wF-3t5oA:
undetectable		 3m0wC-3t5oA:
8.29
3m0wD-3t5oA:
8.29
3m0wE-3t5oA:
8.29
3m0wF-3t5oA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_F_P77F203_1
(PROTEIN S100-A4)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 9 LEU A 229
ASP A 228
ILE A 295
ASP A 463
SER A 266
 None
 1.43A 3m0wC-3t5oA:
undetectable
3m0wD-3t5oA:
undetectable
3m0wE-3t5oA:
undetectable
3m0wF-3t5oA:
undetectable		 3m0wC-3t5oA:
8.29
3m0wD-3t5oA:
8.29
3m0wE-3t5oA:
8.29
3m0wF-3t5oA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 10 LEU A 229
ASP A 228
ILE A 295
ASP A 463
SER A 266
 None
 1.45A 3m0wA-3t5oA:
undetectable
3m0wB-3t5oA:
undetectable
3m0wI-3t5oA:
undetectable
3m0wJ-3t5oA:
undetectable		 3m0wA-3t5oA:
8.29
3m0wB-3t5oA:
8.29
3m0wI-3t5oA:
8.29
3m0wJ-3t5oA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		3 / 3 SER A 265
SER A 266
HIS A 343
 None
 0.63A 3mzeA-3t5oA:
undetectable		 3mzeA-3t5oA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		3 / 3 PRO A  88
THR A 516
LEU A  63
 None
 0.67A 3ttrA-3t5oA:
undetectable		 3ttrA-3t5oA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		3 / 3 LEU A 388
LYS A 384
THR A 383
 None
 0.62A 4lj0A-3t5oA:
undetectable		 4lj0A-3t5oA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		3 / 3 THR A 693
THR A 710
PHE A 715
 None
 0.74A 5cxvA-3t5oA:
undetectable		 5cxvA-3t5oA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		4 / 7 ILE A 282
PHE A 233
PHE A 360
ASP A 236
 None
 0.89A 5hieA-3t5oA:
undetectable		 5hieA-3t5oA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_1
(METTL3)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		4 / 4 ASP A 315
HIS A 312
ASN A 174
GLN A 170
 None
 1.44A 5il1A-3t5oA:
0.0		 5il1A-3t5oA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 12 LEU A 302
LEU A 350
GLY A 351
GLY A 352
VAL A 455
 None
 1.11A 5uc1A-3t5oA:
undetectable		 5uc1A-3t5oA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		5 / 12 LEU A 302
LEU A 350
GLY A 351
GLY A 352
VAL A 455
 None
 1.16A 5uc1B-3t5oA:
undetectable		 5uc1B-3t5oA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		4 / 4 LEU A 443
GLY A 442
SER A 441
SER A 440
 None
 1.11A 5uunA-3t5oA:
undetectable		 5uunA-3t5oA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		4 / 4 LEU A 443
GLY A 442
SER A 441
SER A 440
 None
 1.11A 5uunB-3t5oA:
undetectable		 5uunB-3t5oA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		3 / 3 ASP A 605
ASN A 475
ASP A 310
 None
 0.54A 5vopA-3t5oA:
undetectable		 5vopA-3t5oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		3 / 3 ASP A 605
ASN A 475
ASP A 310
 None
 0.60A 5vopB-3t5oA:
undetectable		 5vopB-3t5oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens) 		4 / 5 GLY A 442
LEU A 434
SER A 419
TYR A 358
 None
 1.12A 6ji6A-3t5oA:
undetectable		 6ji6A-3t5oA:
14.00