SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 8 ARG A 221
SER A 217
ASN A 215
LYS A 212
 None
None
A  C   8 ( 4.1A)
None
 1.19A 1hwiB-3t5qA:
undetectable		 1hwiB-3t5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 7 ARG A 221
SER A 217
ASN A 215
LYS A 212
 None
None
A  C   8 ( 4.1A)
None
 1.18A 1hwiC-3t5qA:
undetectable		 1hwiC-3t5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 7 ARG A 221
SER A 217
ASN A 215
LYS A 212
 None
None
A  C   8 ( 4.1A)
None
 1.18A 1hwiD-3t5qA:
undetectable		 1hwiD-3t5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 8 ARG A 221
SER A 217
ASN A 215
LYS A 212
 None
None
A  C   8 ( 4.1A)
None
 1.16A 1hwkA-3t5qA:
undetectable		 1hwkA-3t5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 8 ARG A 221
SER A 217
ASN A 215
LYS A 212
 None
None
A  C   8 ( 4.1A)
None
 1.17A 1hwkC-3t5qA:
undetectable		 1hwkC-3t5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 8 ARG A 221
SER A 217
ASN A 215
LYS A 212
 None
None
A  C   8 ( 4.1A)
None
 1.17A 1hwkD-3t5qA:
undetectable		 1hwkD-3t5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		3 / 3 GLU A  19
LYS A 287
VAL A 285
 None
 0.96A 1l2iA-3t5qA:
undetectable		 1l2iA-3t5qA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 12 LEU A  39
VAL A 199
ALA A 198
LEU A 202
VAL A  31
 None
 1.13A 2c12C-3t5qA:
undetectable		 2c12C-3t5qA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 6 LEU A 307
LEU A 279
PRO A 318
VAL A 270
 None
 0.83A 2dqyC-3t5qA:
undetectable		 2dqyC-3t5qA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 5 LEU A 265
PRO A 318
ILE A 310
ILE A 306
 None
 0.81A 2q9rA-3t5qA:
undetectable		 2q9rA-3t5qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		3 / 3 GLY A 316
ASP A 315
SER A 313
 None
 0.67A 2qhfA-3t5qA:
undetectable		 2qhfA-3t5qA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 8 TRP A 331
VAL A 335
ARG A 329
GLY A 328
 None
None
U  C   2 ( 2.3A)
None
 0.94A 2xh9A-3t5qA:
undetectable		 2xh9A-3t5qA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 10 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.28A 3lxiA-3t5qA:
undetectable		 3lxiA-3t5qA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 11 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.30A 3lxiB-3t5qA:
undetectable		 3lxiB-3t5qA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		3 / 3 ARG A  55
ARG A  52
ILE A 241
 None
 0.89A 4b7qA-3t5qA:
undetectable		 4b7qA-3t5qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		3 / 3 ARG A  55
ARG A  52
ILE A 241
 None
 0.85A 4b7qC-3t5qA:
undetectable		 4b7qC-3t5qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 10 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.35A 4c9nB-3t5qA:
undetectable		 4c9nB-3t5qA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 9 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.31A 4c9pA-3t5qA:
undetectable		 4c9pA-3t5qA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 10 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.31A 4c9pB-3t5qA:
undetectable		 4c9pB-3t5qA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		4 / 5 ARG A 323
ILE A 320
TRP A 317
GLY A 316
 U  C   4 ( 2.8A)
None
None
None
 1.44A 4e7cC-3t5qA:
undetectable		 4e7cC-3t5qA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 10 CYH A 186
HIS A  40
LEU A  38
ALA A  35
LEU A 195
 None
PO4  A 341 ( 4.7A)
None
None
None
 1.28A 4p65A-3t5qA:
undetectable
4p65B-3t5qA:
undetectable
4p65F-3t5qA:
undetectable
4p65H-3t5qA:
undetectable		 4p65A-3t5qA:
5.63
4p65B-3t5qA:
5.59
4p65F-3t5qA:
5.59
4p65H-3t5qA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 9 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.16A 6czmA-3t5qA:
undetectable
6czmB-3t5qA:
undetectable		 6czmA-3t5qA:
23.43
6czmB-3t5qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 9 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.14A 6czmB-3t5qA:
undetectable
6czmC-3t5qA:
undetectable		 6czmB-3t5qA:
23.43
6czmC-3t5qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 9 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.16A 6czmD-3t5qA:
undetectable
6czmE-3t5qA:
undetectable		 6czmD-3t5qA:
23.43
6czmE-3t5qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3t5q NUCLEOPROTEIN
(Mopeia
Lassa
virus
reassortant
29) 		5 / 10 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.17A 6czmE-3t5qA:
undetectable
6czmF-3t5qA:
undetectable		 6czmE-3t5qA:
23.43
6czmF-3t5qA:
23.43