SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 6 GLN A 160
ASP A 158
VAL A 156
HIS A 182
 MG  A 500 (-4.2A)
None
None
None
 1.46A 1ekjG-3t5tA:
undetectable
1ekjH-3t5tA:
undetectable		 1ekjG-3t5tA:
17.78
1ekjH-3t5tA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 ILE A 142
PHE A   7
LEU A   8
ALA A   9
PHE A 138
 None
 1.10A 1og5B-3t5tA:
1.2		 1og5B-3t5tA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 6 TYR A 335
ILE A 357
GLU A 340
ARG A 338
 None
 1.33A 1oniA-3t5tA:
undetectable
1oniC-3t5tA:
undetectable		 1oniA-3t5tA:
14.75
1oniC-3t5tA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 5 ILE A 198
ILE A 212
MET A 104
LEU A 231
 None
 0.94A 1zgyA-3t5tA:
undetectable		 1zgyA-3t5tA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 5 LEU A 179
PRO A 208
ALA A 209
ILE A 212
 None
 0.95A 2aofB-3t5tA:
undetectable		 2aofB-3t5tA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 LYS A 295
GLY A  33
PRO A  32
 MG  A 501 (-2.2A)
None
None
 0.96A 2hreB-3t5tA:
2.3		 2hreB-3t5tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 ASP A 474
ARG A 478
ARG A 249
 None
 0.93A 2j9dA-3t5tA:
undetectable
2j9dC-3t5tA:
undetectable		 2j9dA-3t5tA:
12.63
2j9dC-3t5tA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 11 LEU A  74
ARG A  78
ILE A  80
HIS A 157
TRP A 463
 None
 1.32A 2qd3A-3t5tA:
5.0		 2qd3A-3t5tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 ASN A 325
ARG A 326
ASP A 158
 None
MG  A 500 (-3.3A)
None
 0.88A 2qe6A-3t5tA:
3.6		 2qe6A-3t5tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 ASN A 325
ARG A 326
ASP A 158
 None
MG  A 500 (-3.3A)
None
 0.89A 2qe6B-3t5tA:
3.7		 2qe6B-3t5tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 4 LEU A 313
ARG A 419
LEU A 375
ALA A 438
 None
 1.10A 3b9mA-3t5tA:
undetectable		 3b9mA-3t5tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 GLU A 197
GLY A 201
THR A 200
 None
 0.51A 3iazA-3t5tA:
undetectable		 3iazA-3t5tA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 ARG A  83
GLU A   5
TYR A 154
 None
 0.85A 3k37B-3t5tA:
undetectable		 3k37B-3t5tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 8 ASP A 383
SER A 380
PHE A 378
PHE A 390
 None
 0.93A 3m0wE-3t5tA:
undetectable
3m0wF-3t5tA:
undetectable
3m0wG-3t5tA:
undetectable
3m0wH-3t5tA:
undetectable		 3m0wE-3t5tA:
11.45
3m0wF-3t5tA:
11.45
3m0wG-3t5tA:
11.45
3m0wH-3t5tA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 6 THR A 381
ILE A 193
TYR A 190
THR A 407
 None
 0.86A 3q70A-3t5tA:
undetectable		 3q70A-3t5tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 8 SER A 226
TRP A 185
PHE A 214
GLU A 225
 None
 1.27A 4cx7C-3t5tA:
undetectable
4cx7D-3t5tA:
undetectable		 4cx7C-3t5tA:
20.99
4cx7D-3t5tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 6 LEU A 284
ASP A 353
VAL A 305
ALA A 308
 None
 1.19A 4nkvC-3t5tA:
undetectable		 4nkvC-3t5tA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 ILE A 403
ALA A 436
THR A 354
THR A 316
VAL A 355
 None
 1.19A 4qynA-3t5tA:
undetectable		 4qynA-3t5tA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 ILE A 403
ALA A 436
THR A 354
THR A 316
VAL A 355
 None
 1.20A 4qzuA-3t5tA:
undetectable		 4qzuA-3t5tA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 ILE A 403
ALA A 436
THR A 354
THR A 316
VAL A 355
 None
 1.09A 4qzuC-3t5tA:
undetectable		 4qzuC-3t5tA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 8 PHE A 134
ARG A 136
ALA A 139
PHE A 215
 None
 1.03A 4rkuA-3t5tA:
undetectable
4rkuJ-3t5tA:
undetectable		 4rkuA-3t5tA:
19.89
4rkuJ-3t5tA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 ALA A 141
LYS A 144
LEU A 143
VAL A 156
ALA A   9
 None
 1.27A 4x1iB-3t5tA:
5.1		 4x1iB-3t5tA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 313
LEU A 375
ALA A 432
ALA A 307
ILE A 403
 None
 1.09A 4x1iD-3t5tA:
3.2		 4x1iD-3t5tA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 313
LEU A 375
ALA A 432
ALA A 307
ILE A 403
 None
 1.07A 4x1yD-3t5tA:
5.5		 4x1yD-3t5tA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 9 PHE A 134
ARG A 136
ALA A 139
GLY A 132
PHE A 215
 None
 1.19A 4y28A-3t5tA:
undetectable
4y28J-3t5tA:
undetectable		 4y28A-3t5tA:
20.08
4y28J-3t5tA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 VAL A  38
ARG A 218
PRO A 184
 None
 0.70A 5koxA-3t5tA:
undetectable		 5koxA-3t5tA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 7 SER A 388
PRO A 393
SER A 380
ASN A 386
 None
 1.18A 5l1fC-3t5tA:
undetectable		 5l1fC-3t5tA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 8 LEU A 460
LEU A  74
MET A  72
ILE A  80
 None
 0.99A 5mzjA-3t5tA:
undetectable		 5mzjA-3t5tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 LYS A  11
TRP A  50
SER A  53
 MG  A 500 (-3.1A)
None
None
 0.84A 5nwwA-3t5tA:
undetectable		 5nwwA-3t5tA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 194
LEU A 179
VAL A 181
PHE A 134
GLY A 127
 None
 1.03A 5uxdB-3t5tA:
undetectable		 5uxdB-3t5tA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 4 PRO A 186
MET A 206
GLY A 163
VAL A 181
 None
 1.42A 6ak3A-3t5tA:
undetectable		 6ak3A-3t5tA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A  30
ILE A  80
VAL A  45
LEU A  84
ALA A  52
 None
 1.23A 6djzA-3t5tA:
undetectable		 6djzA-3t5tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 ALA A  28
LEU A  30
VAL A  45
LEU A  84
ALA A  52
 None
 0.96A 6djzC-3t5tA:
undetectable		 6djzC-3t5tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 6 LEU A 376
ALA A 392
LEU A 284
SER A 288
 None
 0.97A 6f88B-3t5tA:
undetectable		 6f88B-3t5tA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 10 VAL A 227
PHE A 223
ILE A 212
ALA A 166
LEU A 207
 None
 1.45A 6h1lA-3t5tA:
undetectable		 6h1lA-3t5tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3t5t PUTATIVE
GLYCOSYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 11 VAL A 227
PHE A 223
ILE A 212
ALA A 166
LEU A 207
 None
 1.32A 6h1lB-3t5tA:
undetectable		 6h1lB-3t5tA:
23.18