SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 109
ALA B 103
LEU B  98
SER B 155
 None
 0.89A 1dvtA-3t5vB:
undetectable
1dvtB-3t5vB:
undetectable		 1dvtA-3t5vB:
12.75
1dvtB-3t5vB:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		5 / 12 TYR B 343
LEU B 404
LEU B 407
TYR B 365
ILE B 368
 None
 1.22A 1fmlA-3t5vB:
undetectable		 1fmlA-3t5vB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		5 / 12 TYR B 343
LEU B 404
LEU B 407
TYR B 365
ILE B 368
 None
 1.22A 1fmlB-3t5vB:
undetectable		 1fmlB-3t5vB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		5 / 12 ILE B  63
LEU B  19
LEU B   8
PHE B  68
LEU B  69
 None
 1.05A 1g5yB-3t5vB:
undetectable		 1g5yB-3t5vB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 407
LEU B 372
ILE B 311
MET B 340
 None
 1.06A 1n13I-3t5vB:
undetectable
1n13L-3t5vB:
undetectable		 1n13I-3t5vB:
8.20
1n13L-3t5vB:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 HIS B 395
THR B 342
TYR B 343
LEU B 407
 None
 1.01A 1qzrA-3t5vB:
undetectable		 1qzrA-3t5vB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 HIS B 395
THR B 342
TYR B 343
LEU B 407
 None
 1.01A 1qzrB-3t5vB:
undetectable		 1qzrB-3t5vB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 222
ASN B 212
LEU B 176
GLN B 219
 None
 1.00A 1qzrB-3t5vB:
undetectable		 1qzrB-3t5vB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 103
ASP B 101
ASN B  96
ARG B 151
ILE B 145
 None
 1.16A 1xvaB-3t5vB:
undetectable		 1xvaB-3t5vB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 4 ILE B 145
ASP B  85
LEU B  21
ARG B 151
 None
 1.39A 2a7qA-3t5vB:
undetectable		 2a7qA-3t5vB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 407
LEU B 372
ILE B 311
MET B 340
 None
 0.99A 2qqdA-3t5vB:
undetectable
2qqdE-3t5vB:
undetectable		 2qqdA-3t5vB:
7.97
2qqdE-3t5vB:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3t5v 26S PROTEASOME
COMPLEX SUBUNIT SEM1
NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 6 PRO B 364
SER B 366
GLU C  87
TYR C  84
 None
 0.85A 2x7hA-3t5vB:
undetectable		 2x7hA-3t5vB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 187
CYH B 195
PHE B 199
 None
 0.69A 3cr5X-3t5vB:
undetectable		 3cr5X-3t5vB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3t5v 26S PROTEASOME
COMPLEX SUBUNIT SEM1
NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 224
GLU C  30
LEU B 225
ASN B 184
 None
 1.14A 3k8mA-3t5vB:
undetectable		 3k8mA-3t5vB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3t5v 26S PROTEASOME
COMPLEX SUBUNIT SEM1
NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 224
GLU C  30
LEU B 225
ASN B 184
 None
 1.34A 3k8mB-3t5vB:
undetectable		 3k8mB-3t5vB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 8 CYH B  65
PHE B  68
PHE B  90
PHE B  16
 None
 0.90A 3ko0B-3t5vB:
undetectable
3ko0J-3t5vB:
undetectable		 3ko0B-3t5vB:
13.08
3ko0J-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 8 CYH B  65
PHE B  68
PHE B  90
PHE B  16
 None
 0.93A 3ko0D-3t5vB:
undetectable
3ko0E-3t5vB:
undetectable		 3ko0D-3t5vB:
13.08
3ko0E-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 PHE B  16
CYH B  65
PHE B  68
PHE B  90
 None
 0.94A 3ko0D-3t5vB:
undetectable
3ko0E-3t5vB:
undetectable		 3ko0D-3t5vB:
13.08
3ko0E-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 8 PHE B  16
CYH B  65
PHE B  68
PHE B  90
 None
 0.84A 3ko0B-3t5vB:
undetectable
3ko0J-3t5vB:
undetectable		 3ko0B-3t5vB:
13.08
3ko0J-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 8 CYH B  65
PHE B  68
PHE B  90
PHE B  16
 None
 0.91A 3ko0K-3t5vB:
undetectable
3ko0S-3t5vB:
undetectable		 3ko0K-3t5vB:
13.08
3ko0S-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 CYH B  65
PHE B  68
PHE B  90
PHE B  16
 None
 1.01A 3ko0L-3t5vB:
undetectable
3ko0N-3t5vB:
undetectable		 3ko0L-3t5vB:
13.08
3ko0N-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 PHE B  16
CYH B  65
PHE B  68
PHE B  90
 None
 0.85A 3ko0M-3t5vB:
undetectable
3ko0P-3t5vB:
undetectable		 3ko0M-3t5vB:
13.08
3ko0P-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 8 PHE B  16
CYH B  65
PHE B  68
PHE B  90
 None
 0.92A 3ko0O-3t5vB:
undetectable
3ko0Q-3t5vB:
undetectable		 3ko0O-3t5vB:
13.08
3ko0Q-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 PHE B  16
CYH B  65
PHE B  68
PHE B  90
 None
 0.84A 3ko0K-3t5vB:
undetectable
3ko0S-3t5vB:
undetectable		 3ko0K-3t5vB:
13.08
3ko0S-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 7 PHE B  16
CYH B  65
PHE B  68
PHE B  90
 None
 0.92A 3ko0R-3t5vB:
undetectable
3ko0T-3t5vB:
undetectable		 3ko0R-3t5vB:
13.08
3ko0T-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3t5v 26S PROTEASOME
COMPLEX SUBUNIT SEM1
NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 8 GLU C  36
ARG B 266
ARG B 262
ASP C  32
 None
 1.12A 3mjrD-3t5vC:
undetectable		 3mjrD-3t5vC:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		3 / 3 TYR B 229
LEU B 250
ARG B 228
 None
 0.72A 3sufB-3t5vB:
undetectable		 3sufB-3t5vB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		5 / 11 PHE B 199
VAL B 179
ASN B 183
LEU B 176
PHE B 211
 None
 1.09A 3t3rA-3t5vB:
undetectable		 3t3rA-3t5vB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		5 / 12 TYR B 224
ASN B 180
GLU B 118
TYR B 177
LEU B 176
 None
 1.32A 5czyA-3t5vB:
undetectable		 5czyA-3t5vB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		4 / 6 ARG B 266
PHE B 247
PHE B 243
THR B 274
 None
 0.91A 5vceA-3t5vB:
undetectable		 5vceA-3t5vB:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		3 / 3 GLN B 235
TYR B 230
ASN B 233
 None
 0.89A 6dwdC-3t5vB:
undetectable		 6dwdC-3t5vB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 152
SER B 150
ILE B  99
ARG B 151
ILE B  95
 None
 1.21A 6ef6A-3t5vB:
undetectable		 6ef6A-3t5vB:
19.75