SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 8 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.60A 1c9sI-3t63M:
undetectable
1c9sJ-3t63M:
undetectable		 1c9sI-3t63M:
12.18
1c9sJ-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 8 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.63A 1c9sU-3t63M:
undetectable
1c9sV-3t63M:
undetectable		 1c9sU-3t63M:
12.18
1c9sV-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 7 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.58A 1gtnA-3t63M:
undetectable
1gtnK-3t63M:
undetectable		 1gtnA-3t63M:
12.18
1gtnK-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 8 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.57A 1gtnA-3t63M:
undetectable
1gtnB-3t63M:
0.6		 1gtnA-3t63M:
12.18
1gtnB-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 7 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.60A 1gtnC-3t63M:
undetectable
1gtnD-3t63M:
undetectable		 1gtnC-3t63M:
12.18
1gtnD-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 6 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.55A 1gtnD-3t63M:
undetectable
1gtnE-3t63M:
undetectable		 1gtnD-3t63M:
12.18
1gtnE-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 8 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.60A 1gtnE-3t63M:
undetectable
1gtnF-3t63M:
undetectable		 1gtnE-3t63M:
12.18
1gtnF-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 7 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.59A 1gtnF-3t63M:
undetectable
1gtnG-3t63M:
undetectable		 1gtnF-3t63M:
12.18
1gtnG-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 8 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.50A 1gtnI-3t63M:
undetectable
1gtnJ-3t63M:
undetectable		 1gtnI-3t63M:
12.18
1gtnJ-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 7 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.57A 1gtnJ-3t63M:
undetectable
1gtnK-3t63M:
undetectable		 1gtnJ-3t63M:
12.18
1gtnK-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 8 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.65A 1gtnP-3t63M:
0.6
1gtnQ-3t63M:
0.8		 1gtnP-3t63M:
12.18
1gtnQ-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		3 / 3 GLU M 499
ASN M 497
TRP M 315
 None
 1.21A 1r15C-3t63M:
undetectable		 1r15C-3t63M:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		3 / 3 GLU M 499
ASN M 497
TRP M 315
 None
 1.26A 1r15D-3t63M:
undetectable		 1r15D-3t63M:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		3 / 3 GLU M 499
ASN M 497
TRP M 315
 None
 1.23A 1r15E-3t63M:
undetectable		 1r15E-3t63M:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		3 / 3 GLU M 499
ASN M 497
TRP M 315
 None
 1.24A 1r15F-3t63M:
undetectable		 1r15F-3t63M:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		5 / 12 ILE M 491
TYR M 408
HIS M 460
GLN M 477
CYH M 489
 None
BME  M   1 ( 4.4A)
FE  M 600 ( 3.4A)
BME  M   1 ( 4.9A)
None
 1.49A 1s9aB-3t63M:
13.3		 1s9aB-3t63M:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		5 / 12 TYR M 408
ARG M 457
HIS M 460
GLN M 477
CYH M 489
 BME  M   1 ( 4.4A)
BME  M   1 (-3.9A)
FE  M 600 ( 3.4A)
BME  M   1 ( 4.9A)
None
 1.38A 1s9aB-3t63M:
13.3		 1s9aB-3t63M:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 8 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.61A 1utdF-3t63M:
undetectable
1utdG-3t63M:
undetectable		 1utdF-3t63M:
12.18
1utdG-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 8 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.56A 1utdI-3t63M:
undetectable
1utdJ-3t63M:
0.6		 1utdI-3t63M:
12.18
1utdJ-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 5 PHE M 439
PHE M 463
LEU M 478
PHE M 480
 None
 1.38A 2y69C-3t63M:
undetectable
2y69J-3t63M:
undetectable		 2y69C-3t63M:
19.64
2y69J-3t63M:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 5 PHE M 439
PHE M 463
LEU M 478
PHE M 480
 None
 1.37A 3abmC-3t63M:
undetectable
3abmJ-3t63M:
undetectable		 3abmC-3t63M:
19.64
3abmJ-3t63M:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 5 PHE M 439
PHE M 463
LEU M 478
PHE M 480
 None
 1.39A 3abmP-3t63M:
undetectable
3abmW-3t63M:
undetectable		 3abmP-3t63M:
19.64
3abmW-3t63M:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		5 / 9 ILE M 461
VAL M 380
THR M 441
ILE M 442
ILE M 378
 None
 1.20A 3p4wB-3t63M:
undetectable		 3p4wB-3t63M:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		5 / 10 ILE M 461
VAL M 380
THR M 441
ILE M 442
ILE M 378
 None
 1.18A 3p4wD-3t63M:
undetectable		 3p4wD-3t63M:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		5 / 10 ILE M 461
VAL M 380
THR M 441
ILE M 442
ILE M 378
 None
 1.18A 3p4wE-3t63M:
undetectable		 3p4wE-3t63M:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 5 ASN M 403
ALA M 402
TYR M 415
ALA M 417
 None
 1.32A 3twpD-3t63M:
undetectable		 3twpD-3t63M:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		3 / 3 ARG M 457
TRP M 449
ILE M 491
 BME  M   1 (-3.9A)
BME  M 542 (-4.4A)
None
 0.76A 4mwxA-3t63M:
undetectable		 4mwxA-3t63M:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		3 / 3 ARG M 522
ASP M 524
TYR M 436
 None
GOL  M 541 (-4.5A)
None
 0.93A 4yo9B-3t63M:
undetectable		 4yo9B-3t63M:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		4 / 5 PRO M 468
THR M 346
GLN M 530
THR M 533
 None
 1.23A 5h5fA-3t63M:
undetectable		 5h5fA-3t63M:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		3 / 3 HIS M 361
SER M 438
ARG M 440
 None
 0.78A 5u63A-3t63M:
undetectable		 5u63A-3t63M:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN
(Pseudomonas
putida) 		3 / 3 LEU M 354
SER M 352
PHE M 351
 None
 0.54A 6fgcA-3t63M:
undetectable		 6fgcA-3t63M:
19.29