SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		5 / 11 ALA A  99
LEU A 100
ARG A 391
LEU A 137
ALA A 109
 None
 0.98A 1h9zA-3t66A:
undetectable		 1h9zA-3t66A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		3 / 3 PHE A 453
TYR A 397
PRO A 286
 None
 1.15A 1mcnA-3t66A:
undetectable
1mcnB-3t66A:
undetectable
1mcnP-3t66A:
undetectable		 1mcnA-3t66A:
18.16
1mcnB-3t66A:
18.16
1mcnP-3t66A:
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		5 / 11 SER A  95
ILE A 106
LEU A 110
LEU A  45
LEU A 137
 None
 1.24A 2a15A-3t66A:
undetectable		 2a15A-3t66A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		5 / 10 LEU A 381
PHE A 350
LEU A 330
ILE A 359
ALA A 261
 None
 1.06A 2bxeB-3t66A:
undetectable		 2bxeB-3t66A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		6 / 12 LEU A 137
PHE A 133
HIS A  29
LEU A 100
ILE A 112
ILE A 115
 None
 1.49A 2bxqA-3t66A:
undetectable		 2bxqA-3t66A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 4 LEU A 244
THR A 245
ILE A 455
HIS A 242
 None
 1.13A 2jfaB-3t66A:
undetectable		 2jfaB-3t66A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 5 PHE A  19
PHE A 193
LEU A 173
PHE A 167
 None
 1.32A 2y69P-3t66A:
undetectable
2y69W-3t66A:
undetectable		 2y69P-3t66A:
20.72
2y69W-3t66A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 4 LEU A 100
ARG A 391
LEU A 137
ALA A 109
 None
 0.90A 3b9mA-3t66A:
undetectable		 3b9mA-3t66A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 7 TYR A 402
ASN A 243
LEU A 381
PHE A 453
 None
 1.25A 3nk2X-3t66A:
undetectable		 3nk2X-3t66A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 6 GLN A 448
TYR A 444
GLN A 440
ILE A 421
 None
 1.15A 3peoG-3t66A:
undetectable		 3peoG-3t66A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 8 SER A 194
ASP A 212
GLU A 174
GLU A 165
 None
 1.05A 3sg9B-3t66A:
undetectable		 3sg9B-3t66A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 5 LEU A  26
ALA A  39
THR A  23
PHE A 193
 None
 1.08A 3vasB-3t66A:
undetectable		 3vasB-3t66A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		5 / 11 PHE A 133
ILE A 115
VAL A  92
LEU A  96
VAL A 142
 None
 1.15A 3w67A-3t66A:
undetectable		 3w67A-3t66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		5 / 12 LEU A  75
PHE A 133
ILE A 115
VAL A  92
VAL A 142
 None
 1.15A 3w68A-3t66A:
undetectable		 3w68A-3t66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		5 / 12 PHE A 133
ILE A 115
VAL A  92
LEU A  96
VAL A 142
 None
 1.17A 3w68A-3t66A:
undetectable		 3w68A-3t66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		5 / 12 LEU A  75
PHE A 133
ILE A 115
LEU A  96
VAL A 142
 None
 1.02A 3w68B-3t66A:
undetectable		 3w68B-3t66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 8 SER A 385
HIS A 242
TYR A 337
GLU A 342
 None
 1.27A 4ms4A-3t66A:
2.1		 4ms4A-3t66A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		3 / 3 GLY A 160
PRO A 161
ALA A 185
 None
 0.52A 4qn9B-3t66A:
undetectable		 4qn9B-3t66A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 5 ALA A  56
HIS A 456
PRO A 292
PHE A 239
 None
 1.19A 4ze2A-3t66A:
undetectable		 4ze2A-3t66A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 5 PHE A  19
PHE A 193
LEU A 173
PHE A 167
 None
 1.34A 5wauC-3t66A:
undetectable
5wauJ-3t66A:
undetectable		 5wauC-3t66A:
20.72
5wauJ-3t66A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 5 PHE A  19
PHE A 193
LEU A 173
PHE A 167
 None
 1.35A 5wauc-3t66A:
undetectable
5wauj-3t66A:
undetectable		 5wauc-3t66A:
20.72
5wauj-3t66A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 5 PHE A  19
PHE A 193
LEU A 173
PHE A 167
 None
 1.29A 5xdqC-3t66A:
undetectable
5xdqJ-3t66A:
undetectable		 5xdqC-3t66A:
20.72
5xdqJ-3t66A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)
(Bacillus
halodurans) 		4 / 5 PHE A  19
PHE A 193
LEU A 173
PHE A 167
 None
 1.30A 5xdqP-3t66A:
undetectable
5xdqW-3t66A:
undetectable		 5xdqP-3t66A:
20.72
5xdqW-3t66A:
9.15