SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		5 / 9 ASP A 622
ILE A 613
ALA A 653
ILE A 659
THR A 626
 None
 1.43A 1aj6A-3t6aA:
undetectable		 1aj6A-3t6aA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		4 / 8 LEU A 716
LEU A 644
LEU A 709
THR A 746
 None
None
None
POG  A 834 ( 4.5A)
 0.89A 1dvtA-3t6aA:
undetectable
1dvtB-3t6aA:
undetectable		 1dvtA-3t6aA:
16.22
1dvtB-3t6aA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		4 / 7 TRP A 666
LEU A 669
THR A 676
LEU A 654
 None
 0.95A 1gtiA-3t6aA:
1.6		 1gtiA-3t6aA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		3 / 4 LYS A 550
ALA A 553
MET A 641
 None
 0.82A 1hk3A-3t6aA:
undetectable		 1hk3A-3t6aA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 811
LEU A 815
ILE A 613
THR A 626
LEU A 532
 None
 1.13A 1tw4A-3t6aA:
undetectable		 1tw4A-3t6aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 811
LEU A 815
ILE A 613
THR A 626
LEU A 532
 None
 1.13A 1tw4B-3t6aA:
undetectable		 1tw4B-3t6aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		3 / 3 ALA A 721
VAL A 722
GLN A 797
 None
 0.67A 3of4B-3t6aA:
undetectable		 3of4B-3t6aA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		4 / 4 PRO A 708
LEU A 710
ILE A 598
ARG A 595
 None
 1.21A 3w1wA-3t6aA:
undetectable		 3w1wA-3t6aA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		4 / 7 MET A 711
LEU A 709
SER A 648
HIS A 602
 None
 1.25A 4aq7A-3t6aA:
undetectable		 4aq7A-3t6aA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		5 / 11 ARG A 562
PHE A 768
VAL A 551
ILE A 777
MET A 641
 None
 1.36A 4dz2A-3t6aA:
undetectable
4dz2B-3t6aA:
undetectable		 4dz2A-3t6aA:
14.33
4dz2B-3t6aA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		5 / 11 MET A 641
ARG A 562
PHE A 768
VAL A 551
ILE A 777
 None
 1.39A 4dz2A-3t6aA:
undetectable
4dz2B-3t6aA:
undetectable		 4dz2A-3t6aA:
14.33
4dz2B-3t6aA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		4 / 5 LEU A 525
PHE A 524
PHE A 782
LEU A 786
 None
 0.96A 5x1bP-3t6aA:
undetectable		 5x1bP-3t6aA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		3 / 3 ASP A 643
LEU A 557
ARG A 562
 None
 0.90A 7dfrA-3t6aA:
undetectable		 7dfrA-3t6aA:
18.73