SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 6 TYR A 150
ILE A 122
TYR A 374
GLY A 373
 None
 1.15A 1maaB-3t6cA:
undetectable
1maaD-3t6cA:
undetectable		 1maaB-3t6cA:
20.14
1maaD-3t6cA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 TYR A 158
TYR A 199
GLN A 154
HIS A 325
 GCO  A 601 (-4.4A)
None
None
GCO  A 601 (-3.9A)
 1.18A 1nx9A-3t6cA:
undetectable		 1nx9A-3t6cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 TYR A 158
TYR A 199
GLN A 154
HIS A 325
 GCO  A 601 (-4.4A)
None
None
GCO  A 601 (-3.9A)
 1.18A 1nx9B-3t6cA:
undetectable		 1nx9B-3t6cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 TYR A 158
TYR A 199
GLN A 154
HIS A 325
 GCO  A 601 (-4.4A)
None
None
GCO  A 601 (-3.9A)
 1.19A 1nx9C-3t6cA:
undetectable		 1nx9C-3t6cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 TYR A 158
TYR A 199
GLN A 154
HIS A 325
 GCO  A 601 (-4.4A)
None
None
GCO  A 601 (-3.9A)
 1.19A 1nx9D-3t6cA:
undetectable		 1nx9D-3t6cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 5 PHE A 348
ILE A 350
TYR A 294
ARG A 321
 None
 1.32A 1qltA-3t6cA:
0.3		 1qltA-3t6cA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 LEU A 113
LEU A 114
SER A 344
 None
 0.59A 1tlmA-3t6cA:
undetectable		 1tlmA-3t6cA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 7 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.13A 1tv8A-3t6cA:
2.6		 1tv8A-3t6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 7 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.11A 1tv8B-3t6cA:
4.1		 1tv8B-3t6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 5 ASP A 342
PRO A 368
VAL A 377
ILE A 122
 None
 0.88A 2aoiA-3t6cA:
undetectable		 2aoiA-3t6cA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 5 ASP A 342
PRO A 368
VAL A 377
ILE A 122
 None
 1.00A 2aoiB-3t6cA:
undetectable		 2aoiB-3t6cA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 8 THR A 322
GLU A 316
SER A 344
VAL A 110
MET A  96
 None
 1.36A 2fb2A-3t6cA:
4.3		 2fb2A-3t6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 7 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.17A 2fb2B-3t6cA:
4.5		 2fb2B-3t6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 ASP A 208
THR A 269
PRO A 270
 None
 0.61A 2pynB-3t6cA:
undetectable		 2pynB-3t6cA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 ASP A 208
THR A 269
PRO A 270
 None
 0.62A 2qakB-3t6cA:
undetectable		 2qakB-3t6cA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 GLY A 130
ASP A 129
SER A 139
 None
 0.72A 2qhfA-3t6cA:
undetectable		 2qhfA-3t6cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 10 TYR A 199
ALA A 233
ALA A 237
THR A 269
LEU A 245
 None
 1.43A 2wuzA-3t6cA:
undetectable		 2wuzA-3t6cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 10 TYR A 199
ALA A 233
ALA A 237
THR A 269
LEU A 245
 None
 1.44A 2wuzB-3t6cA:
undetectable		 2wuzB-3t6cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 9 TYR A 199
ALA A 233
ALA A 237
THR A 269
LEU A 245
 None
 1.47A 2wv2A-3t6cA:
0.0		 2wv2A-3t6cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 ALA A  76
GLN A  73
ILE A  68
VAL A  24
LEU A  60
 None
EDO  A 706 ( 4.8A)
None
None
None
 1.06A 3dzuA-3t6cA:
undetectable		 3dzuA-3t6cA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 ILE A 305
VAL A  24
VAL A   9
LEU A  60
ILE A  71
 None
 1.14A 3gwxB-3t6cA:
undetectable		 3gwxB-3t6cA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 GLY A  37
ASN A 338
GLY A  93
SER A  92
GLY A 304
 None
 1.06A 3huoB-3t6cA:
undetectable		 3huoB-3t6cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 GLY A 334
SER A 331
ASP A  95
ILE A 305
LEU A 383
 None
 1.21A 3iv6D-3t6cA:
undetectable		 3iv6D-3t6cA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 4 ARG A 167
ASP A 223
GLY A 159
THR A 163
 None
MG  A 501 ( 2.5A)
None
None
 1.18A 3k4vB-3t6cA:
undetectable		 3k4vB-3t6cA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 11 ALA A 308
ILE A 299
ASP A  95
LEU A 341
ALA A 337
 None
 1.13A 3kw2A-3t6cA:
undetectable		 3kw2A-3t6cA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 THR A 128
ILE A 228
ALA A 233
ILE A 271
ALA A 272
 None
 1.12A 3nxuB-3t6cA:
undetectable		 3nxuB-3t6cA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 6 ILE A  12
GLU A 389
ALA A 393
ASN A 388
 None
 1.14A 3pgyA-3t6cA:
undetectable
3pgyB-3t6cA:
undetectable		 3pgyA-3t6cA:
22.72
3pgyB-3t6cA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 LEU A 343
HIS A 340
MET A 339
 None
 0.95A 3thrD-3t6cA:
undetectable		 3thrD-3t6cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 7 ILE A 385
GLY A  37
VAL A  23
SER A 331
 None
 0.87A 4a3uB-3t6cA:
6.1		 4a3uB-3t6cA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 11 TYR A 158
LEU A 214
GLN A 154
ILE A 151
TYR A 199
 GCO  A 601 (-4.4A)
None
None
None
None
 1.49A 4a7aA-3t6cA:
undetectable		 4a7aA-3t6cA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 GLY A 103
ALA A 106
ILE A 101
VAL A 110
ILE A 305
 None
 0.92A 4ax8A-3t6cA:
undetectable		 4ax8A-3t6cA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 GLY A 103
ALA A 106
ILE A 101
VAL A 110
ILE A 305
 None
 0.93A 4azvA-3t6cA:
undetectable		 4azvA-3t6cA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 ASP A 129
HIS A 127
TYR A 199
GLY A 160
LEU A 221
 None
None
None
EDO  A 703 (-4.2A)
None
 1.24A 4blvB-3t6cA:
undetectable		 4blvB-3t6cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 ARG A 227
THR A 403
TRP A 404
 None
 1.25A 4d7hA-3t6cA:
undetectable		 4d7hA-3t6cA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 ARG A 227
THR A 403
TRP A 404
 None
 1.26A 4ug5A-3t6cA:
undetectable		 4ug5A-3t6cA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 ARG A 227
THR A 403
TRP A 404
 None
 1.21A 4uglA-3t6cA:
undetectable		 4uglA-3t6cA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 7 PHE A 246
ALA A 272
PRO A 270
LEU A 248
 None
 1.07A 5dzkD-3t6cA:
undetectable
5dzkR-3t6cA:
undetectable		 5dzkD-3t6cA:
19.32
5dzkR-3t6cA:
1.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		3 / 3 ARG A 227
THR A 403
TRP A 404
 None
 1.28A 5g6cA-3t6cA:
undetectable		 5g6cA-3t6cA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 HIS A 225
TYR A 158
PRO A 327
TYR A 125
 GCO  A 601 (-3.9A)
GCO  A 601 (-4.4A)
GCO  A 601 (-4.0A)
None
 1.15A 5v4vA-3t6cA:
6.9		 5v4vA-3t6cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 HIS A 225
TYR A 158
PRO A 327
TYR A 125
 GCO  A 601 (-3.9A)
GCO  A 601 (-4.4A)
GCO  A 601 (-4.0A)
None
 1.16A 5v4vB-3t6cA:
5.8		 5v4vB-3t6cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 9 GLY A 103
ALA A 106
GLY A 382
LEU A 383
GLU A 112
 None
 1.27A 5vw4A-3t6cA:
undetectable		 5vw4A-3t6cA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 ASN A 338
HIS A 298
GLU A 352
ARG A 296
 None
None
GCO  A 601 (-2.8A)
GCO  A 601 (-4.1A)
 1.14A 6b94A-3t6cA:
undetectable		 6b94A-3t6cA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 ASN A 388
PRO A 365
ILE A 385
VAL A  23
ILE A 333
 None
 1.09A 6hlpA-3t6cA:
undetectable		 6hlpA-3t6cA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 12 GLY A 366
CYH A 367
TYR A 353
ILE A 333
MET A 356
 None
 1.28A 6md4A-3t6cA:
undetectable		 6md4A-3t6cA:
12.31