SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLU A 560
ARG A 563
ARG A 564
GLU A 551
 None
 0.87A 1cmaA-3t6pA:
undetectable
1cmaB-3t6pA:
1.3		 1cmaA-3t6pA:
14.58
1cmaB-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 1.02A 1cmaA-3t6pA:
undetectable
1cmaB-3t6pA:
1.3		 1cmaA-3t6pA:
14.58
1cmaB-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 1.04A 1cmcA-3t6pA:
undetectable
1cmcB-3t6pA:
undetectable		 1cmcA-3t6pA:
14.58
1cmcB-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 1.00A 1mj2A-3t6pA:
undetectable
1mj2B-3t6pA:
undetectable		 1mj2A-3t6pA:
14.58
1mj2B-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 1.01A 1mj2A-3t6pA:
undetectable		 1mj2A-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 1.02A 1mj2C-3t6pA:
undetectable		 1mj2C-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 0.99A 1mj2C-3t6pA:
undetectable
1mj2D-3t6pA:
undetectable		 1mj2C-3t6pA:
14.58
1mj2D-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 1.03A 1mjlA-3t6pA:
undetectable
1mjlB-3t6pA:
1.4		 1mjlA-3t6pA:
14.58
1mjlB-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 0.99A 1mjoA-3t6pA:
undetectable		 1mjoA-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 0.96A 1mjoB-3t6pA:
undetectable		 1mjoB-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 0.98A 1mjoC-3t6pA:
undetectable
1mjoD-3t6pA:
undetectable		 1mjoC-3t6pA:
14.58
1mjoD-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 0.99A 1mjoC-3t6pA:
undetectable		 1mjoC-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASP A 511
ARG A 569
VAL A 475
ILE A 478
ILE A 461
 None
 1.26A 1tcoC-3t6pA:
undetectable		 1tcoC-3t6pA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 4 LEU A 539
ILE A 510
ILE A 513
ALA A 521
 None
 0.78A 2i30A-3t6pA:
2.7		 2i30A-3t6pA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 VAL A 590
ILE A 604
GLY A 607
ILE A 608
ALA A 596
 None
 0.89A 3el0B-3t6pA:
undetectable		 3el0B-3t6pA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 PRO A 280
VAL A 283
THR A 612
GLY A 611
 None
 1.16A 3elzB-3t6pA:
undetectable		 3elzB-3t6pA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 10 ASP A 511
ARG A 569
VAL A 475
ILE A 478
ILE A 461
 None
 1.20A 3uqaA-3t6pA:
undetectable		 3uqaA-3t6pA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 SER A 415
GLU A 317
THR A 419
ASP A 320
 None
 1.39A 3zs3A-3t6pA:
undetectable		 3zs3A-3t6pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 CYH A 306
PHE A 295
GLU A 334
ARG A 614
LEU A 313
 ZN  A1002 (-2.2A)
None
None
None
None
 1.42A 4k38B-3t6pA:
undetectable		 4k38B-3t6pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A 511
ARG A 569
VAL A 475
ILE A 478
ILE A 461
 None
 1.18A 5b8iC-3t6pA:
undetectable		 5b8iC-3t6pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A 313
LYS A 416
THR A 420
TYR A 352
 None
 1.16A 5hbsA-3t6pA:
undetectable		 5hbsA-3t6pA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASP A 511
ARG A 569
VAL A 475
ILE A 478
ILE A 461
 None
 1.10A 5hw8D-3t6pA:
undetectable		 5hw8D-3t6pA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLY A 312
GLY A 311
GLN A 593
 None
 0.44A 5imsA-3t6pA:
undetectable		 5imsA-3t6pA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A 510
ARG A 465
ARG A 569
TYR A 547
 None
 1.04A 6hisA-3t6pA:
undetectable
6hisB-3t6pA:
undetectable		 6hisA-3t6pA:
13.20
6hisB-3t6pA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A 510
ARG A 465
ARG A 569
TYR A 547
 None
 1.03A 6hisB-3t6pA:
undetectable
6hisC-3t6pA:
undetectable		 6hisB-3t6pA:
13.20
6hisC-3t6pA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A 510
ARG A 465
ARG A 569
TYR A 547
 None
 1.03A 6hisC-3t6pA:
undetectable
6hisD-3t6pA:
undetectable		 6hisC-3t6pA:
13.20
6hisD-3t6pA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A 510
ARG A 465
ARG A 569
TYR A 547
 None
 1.03A 6hisD-3t6pA:
undetectable
6hisE-3t6pA:
undetectable		 6hisD-3t6pA:
13.20
6hisE-3t6pA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 TYR A 547
ILE A 510
ARG A 465
ARG A 569
 None
 1.03A 6hisA-3t6pA:
undetectable
6hisE-3t6pA:
undetectable		 6hisA-3t6pA:
13.20
6hisE-3t6pA:
13.20