SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 ALA A 551
LYS A 598
SER A 536
ILE A 537
LEU A 566
None
GOL  A   9 (-3.2A)
None
None
None
1.15A 1ddsB-3t6qA:
undetectable
1ddsB-3t6qA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 8 ILE A 238
ASN A 207
ASN A 228
LEU A 188
None
1.00A 1dzmA-3t6qA:
undetectable
1dzmA-3t6qA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 PHE A  81
GLU A  40
SER A  61
THR A  85
None
1.15A 1icuA-3t6qA:
undetectable
1icuB-3t6qA:
undetectable
1icuA-3t6qA:
15.55
1icuB-3t6qA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 SER A  61
THR A  85
PHE A  81
GLU A  40
None
1.16A 1icuC-3t6qA:
undetectable
1icuD-3t6qA:
undetectable
1icuC-3t6qA:
15.55
1icuD-3t6qA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 8 LEU A 519
SER A 460
ASN A 490
GLN A 463
None
1.00A 1ig3A-3t6qA:
undetectable
1ig3B-3t6qA:
undetectable
1ig3A-3t6qA:
16.78
1ig3B-3t6qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 GLN A 463
LEU A 519
SER A 460
ASN A 490
None
1.16A 1ig3A-3t6qA:
undetectable
1ig3B-3t6qA:
undetectable
1ig3A-3t6qA:
16.78
1ig3B-3t6qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 SER A  61
THR A  85
PHE A  81
GLU A  40
None
1.17A 1kqbC-3t6qA:
undetectable
1kqbD-3t6qA:
undetectable
1kqbC-3t6qA:
16.17
1kqbD-3t6qA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 LEU A 196
MET A 193
SER A 163
ILE A 185
PHE A 180
GOL  A   3 (-3.6A)
None
None
None
None
1.49A 1osvB-3t6qA:
undetectable
1osvB-3t6qA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 THR A 135
LEU A 106
PHE A  73
ALA A 117
ALA A 120
None
1.21A 1q23A-3t6qA:
undetectable
1q23B-3t6qA:
undetectable
1q23A-3t6qA:
16.92
1q23B-3t6qA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus;
Mus
musculus)
4 / 6 ASP C 105
ASP A 376
ASN A 402
GLU C 147
None
NAG  A 801 ( 4.2A)
NAG  A 801 (-1.8A)
None
0.84A 1rjdC-3t6qC:
undetectable
1rjdC-3t6qC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 11 LEU A  58
ILE A  89
LEU A  65
THR A  96
PHE A  73
None
1.47A 1tw4A-3t6qA:
undetectable
1tw4A-3t6qA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.83A 1v55A-3t6qA:
undetectable
1v55J-3t6qA:
undetectable
1v55A-3t6qA:
19.07
1v55J-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 LEU A 206
PHE A 224
PHE A 219
SER A 194
None
GOL  A   3 (-4.2A)
None
None
1.00A 1wrlE-3t6qA:
undetectable
1wrlF-3t6qA:
undetectable
1wrlE-3t6qA:
9.64
1wrlF-3t6qA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
3 / 3 THR A 306
GLU C 103
HIS A 379
None
MAN  A 806 (-3.0A)
MAN  A 806 ( 4.0A)
0.88A 1xwfA-3t6qA:
undetectable
1xwfA-3t6qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
3 / 3 THR A 306
GLU C 103
HIS A 379
None
MAN  A 806 (-3.0A)
MAN  A 806 ( 4.0A)
0.85A 1xwfB-3t6qA:
undetectable
1xwfB-3t6qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
3 / 3 THR A 306
GLU C 103
HIS A 379
None
MAN  A 806 (-3.0A)
MAN  A 806 ( 4.0A)
0.88A 1xwfC-3t6qA:
undetectable
1xwfC-3t6qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
3 / 3 THR A 306
GLU C 103
HIS A 379
None
MAN  A 806 (-3.0A)
MAN  A 806 ( 4.0A)
0.83A 1xwfD-3t6qA:
undetectable
1xwfD-3t6qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)
3t6q LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
5 / 12 ALA C  32
LEU C  83
ILE C  85
PHE C  70
PHE C  51
None
1.40A 1y0xX-3t6qC:
undetectable
1y0xX-3t6qC:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 LEU A  44
ASN A  45
LEU A  84
ILE A  89
None
0.90A 1z95A-3t6qA:
undetectable
1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 LEU A  51
LEU A  84
LEU A  44
ILE A  68
None
0.93A 1z95A-3t6qA:
undetectable
1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 LEU A 457
ASN A 479
LEU A 501
LEU A 450
None
1.02A 1z95A-3t6qA:
undetectable
1z95A-3t6qA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 8 PHE A 344
LEU A 317
LEU A 310
LEU A 305
None
1.05A 2bfpA-3t6qA:
undetectable
2bfpA-3t6qA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 8 PHE A 344
LEU A 317
LEU A 310
LEU A 305
None
1.00A 2bfpB-3t6qA:
undetectable
2bfpB-3t6qA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 10 LEU A 113
LEU A 108
LEU A 130
ILE A 143
ALA A 120
None
1.14A 2bxeB-3t6qA:
undetectable
2bxeB-3t6qA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
3t6q LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
5 / 12 ILE C  55
ALA C  32
VAL C 159
ALA C 157
TYR C  42
None
1.16A 2japA-3t6qC:
undetectable
2japA-3t6qC:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
3t6q LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
5 / 12 ILE C  55
ALA C  32
VAL C 159
ALA C 157
TYR C  42
None
1.16A 2japC-3t6qC:
undetectable
2japC-3t6qC:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A  92
GLN A 100
LEU A  82
LEU A  65
None
1.01A 2qqcB-3t6qA:
undetectable
2qqcC-3t6qA:
undetectable
2qqcB-3t6qA:
10.44
2qqcC-3t6qA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 LEU A  82
LEU A  65
ILE A  92
GLN A 100
None
0.98A 2qqcA-3t6qA:
undetectable
2qqcF-3t6qA:
undetectable
2qqcA-3t6qA:
6.44
2qqcF-3t6qA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 LEU A  82
LEU A  65
ILE A  92
GLN A 100
None
1.01A 2qqcG-3t6qA:
undetectable
2qqcJ-3t6qA:
undetectable
2qqcG-3t6qA:
6.44
2qqcJ-3t6qA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 LEU A  82
LEU A  65
ILE A  92
GLN A 100
None
1.02A 2qqcI-3t6qA:
undetectable
2qqcL-3t6qA:
undetectable
2qqcI-3t6qA:
6.44
2qqcL-3t6qA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 PHE A 239
LEU A 281
PHE A 297
GLY A 253
None
1.01A 2v0mC-3t6qA:
undetectable
2v0mC-3t6qA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 SER A 535
GLN A 493
ILE A 486
ASN A 485
PHE A 516
None
1.39A 2vdyA-3t6qA:
undetectable
2vdyA-3t6qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
4 / 8 ASN A 205
GLY A 208
ASN A 207
ILE C  78
GOL  C  12 ( 4.9A)
None
None
None
0.88A 2yoeB-3t6qA:
undetectable
2yoeC-3t6qA:
undetectable
2yoeB-3t6qA:
19.14
2yoeC-3t6qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.87A 3ag3A-3t6qA:
undetectable
3ag3J-3t6qA:
undetectable
3ag3A-3t6qA:
19.07
3ag3J-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 8 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.86A 3ag3N-3t6qA:
undetectable
3ag3W-3t6qA:
undetectable
3ag3N-3t6qA:
19.07
3ag3W-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 LEU A 206
GLY A 208
LEU A 204
SER A 203
None
0.91A 3aiaA-3t6qA:
undetectable
3aiaA-3t6qA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 MET A 116
PHE A  97
THR A 119
PHE A 132
LEU A 151
None
1.48A 3aobC-3t6qA:
undetectable
3aobC-3t6qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 THR A  72
GLN A 100
LEU A  84
LEU A  82
None
1.16A 3bgdA-3t6qA:
undetectable
3bgdA-3t6qA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 THR A  96
GLN A 100
LEU A  84
LEU A  82
None
1.00A 3bgdA-3t6qA:
undetectable
3bgdA-3t6qA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 THR A  96
GLN A 100
LEU A 106
LEU A  84
None
0.72A 3bgdB-3t6qA:
undetectable
3bgdB-3t6qA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
6 / 12 ILE A 185
ILE A 211
VAL A 237
LYS A 240
GLY A 241
LEU A 204
None
1.38A 3em0B-3t6qA:
undetectable
3em0B-3t6qA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 LEU A 271
ILE A 279
LEU A 300
PHE A 286
SER A 290
None
0.85A 3ko0K-3t6qA:
undetectable
3ko0L-3t6qA:
undetectable
3ko0S-3t6qA:
undetectable
3ko0T-3t6qA:
undetectable
3ko0K-3t6qA:
10.23
3ko0L-3t6qA:
10.23
3ko0S-3t6qA:
10.23
3ko0T-3t6qA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 5 ILE A  47
PHE A  60
ASP A  83
GLU A  59
None
1.16A 3kp6A-3t6qA:
undetectable
3kp6B-3t6qA:
undetectable
3kp6A-3t6qA:
12.83
3kp6B-3t6qA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)
3t6q CD180 ANTIGEN
(Mus
musculus)
3 / 3 ASP A 380
ASN A 406
SER A 329
None
0.87A 3lslA-3t6qA:
undetectable
3lslD-3t6qA:
undetectable
3lslA-3t6qA:
17.83
3lslD-3t6qA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)
3t6q CD180 ANTIGEN
(Mus
musculus)
3 / 3 SER A 329
ASP A 380
ASN A 406
None
0.88A 3lslA-3t6qA:
undetectable
3lslD-3t6qA:
undetectable
3lslA-3t6qA:
17.83
3lslD-3t6qA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
5 / 10 SER A 158
ILE C 120
GLU C 118
LEU C  74
ASP C  77
None
None
GOL  C  12 ( 4.9A)
None
GOL  C   4 ( 4.1A)
1.48A 3m0wC-3t6qA:
undetectable
3m0wD-3t6qA:
undetectable
3m0wE-3t6qA:
undetectable
3m0wF-3t6qA:
undetectable
3m0wC-3t6qA:
11.99
3m0wD-3t6qA:
11.99
3m0wE-3t6qA:
11.99
3m0wF-3t6qA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
3 / 3 ASP A 526
GLU A 600
SER A 453
None
0.83A 3p2kA-3t6qA:
2.0
3p2kA-3t6qA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 5 ASN A 451
ASP A 526
GLU A 600
SER A 453
NAG  A 901 (-2.4A)
None
None
None
1.00A 3p2kC-3t6qA:
undetectable
3p2kC-3t6qA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 SER A 528
ALA A 551
TYR A 547
LEU A 548
ILE A 511
None
1.40A 3qt0A-3t6qA:
undetectable
3qt0A-3t6qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 9 PHE A 268
PHE A 239
PHE A 286
THR A 308
PHE A 294
None
1.39A 3t3rC-3t6qA:
undetectable
3t3rC-3t6qA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 ILE A 546
ALA A 539
LEU A 527
LEU A 503
ILE A 511
None
0.84A 3uvvA-3t6qA:
undetectable
3uvvA-3t6qA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 GLY A 253
PHE A 268
PHE A 239
LEU A 235
None
0.68A 3v7pA-3t6qA:
undetectable
3v7pA-3t6qA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 SER A 535
GLN A 493
ILE A 486
ASN A 485
PHE A 516
None
1.29A 4c49B-3t6qA:
undetectable
4c49B-3t6qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 SER A 535
GLN A 493
ILE A 486
ASN A 485
PHE A 516
None
1.29A 4c49C-3t6qA:
undetectable
4c49C-3t6qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 SER A 535
GLN A 493
ILE A 486
ASN A 485
PHE A 516
None
1.34A 4c49D-3t6qA:
undetectable
4c49D-3t6qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 THR A 517
ILE A 486
ASN A 485
PHE A 516
HIS A 514
None
1.36A 4c49D-3t6qA:
undetectable
4c49D-3t6qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 8 PHE A 481
ALA A 515
LEU A 527
LEU A 508
None
0.84A 4ejgB-3t6qA:
undetectable
4ejgB-3t6qA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 PHE A 481
ALA A 515
LEU A 527
LEU A 508
None
0.87A 4ejgC-3t6qA:
undetectable
4ejgC-3t6qA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 SER A 491
LEU A 492
PHE A 481
ASP A 507
GLY A 478
None
1.32A 4j7xA-3t6qA:
undetectable
4j7xA-3t6qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)
3t6q CD180 ANTIGEN
(Mus
musculus)
3 / 3 ASP A 141
TRP A  91
SER A 138
None
1.06A 4lrhA-3t6qA:
undetectable
4lrhA-3t6qA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A  68
PHE A  97
LEU A  84
THR A 135
None
0.99A 4mmcA-3t6qA:
undetectable
4mmcA-3t6qA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 8 LEU A  84
ASN A 111
HIS A  93
ILE A 114
None
0.86A 4ok1A-3t6qA:
undetectable
4ok1A-3t6qA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 PHE A 224
THR A 232
LEU A 188
LEU A 250
LEU A 242
GOL  A   3 (-4.2A)
None
None
None
None
1.38A 4qynB-3t6qA:
undetectable
4qynB-3t6qA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)
3t6q LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
5 / 12 LEU C  53
LEU C 142
ALA C 157
VAL C  40
ALA C  32
None
1.20A 4x1iB-3t6qC:
undetectable
4x1iB-3t6qC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
None
1.02A 4x1iD-3t6qA:
undetectable
4x1iD-3t6qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
None
1.01A 4x1yD-3t6qA:
undetectable
4x1yD-3t6qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 11 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
None
0.98A 4x20D-3t6qA:
undetectable
4x20D-3t6qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus)
4 / 4 PHE A  62
ASP A  83
GLY C 117
SER A  61
None
1.19A 4xp9C-3t6qA:
undetectable
4xp9C-3t6qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.88A 5b1aA-3t6qA:
undetectable
5b1aJ-3t6qA:
undetectable
5b1aA-3t6qA:
19.07
5b1aJ-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.92A 5b3sA-3t6qA:
undetectable
5b3sJ-3t6qA:
undetectable
5b3sA-3t6qA:
19.07
5b3sJ-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
None
1.03A 5itzB-3t6qA:
undetectable
5itzB-3t6qA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 SER A 245
GLY A 270
MET A 274
ILE A 214
None
1.01A 5j4nA-3t6qA:
undetectable
5j4nA-3t6qA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 ILE A 247
LEU A 271
VAL A 276
ILE A 279
PHE A 286
None
0.96A 5mueA-3t6qA:
undetectable
5mueA-3t6qA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 ILE A 247
LEU A 271
VAL A 276
ILE A 279
PHE A 286
None
0.92A 5mugA-3t6qA:
undetectable
5mugA-3t6qA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus;
Mus
musculus)
4 / 4 GLN C 119
GLN A 134
PRO A 112
ALA A 110
None
1.48A 5odcA-3t6qC:
undetectable
5odcG-3t6qC:
undetectable
5odcA-3t6qC:
12.15
5odcG-3t6qC:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus
musculus;
Mus
musculus)
4 / 5 PRO A 112
ALA A 110
GLN C 119
GLN A 134
None
1.48A 5odcA-3t6qA:
undetectable
5odcG-3t6qA:
undetectable
5odcA-3t6qA:
20.90
5odcG-3t6qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)
3t6q CD180 ANTIGEN
(Mus
musculus)
5 / 12 VAL A 621
ASP A 620
GLN A 597
ARG A 617
LEU A 599
None
1.32A 5syfB-3t6qA:
undetectable
5syfB-3t6qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.90A 5xdqN-3t6qA:
undetectable
5xdqW-3t6qA:
undetectable
5xdqN-3t6qA:
19.07
5xdqW-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.91A 5xdxA-3t6qA:
undetectable
5xdxJ-3t6qA:
undetectable
5xdxA-3t6qA:
19.07
5xdxJ-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.92A 5zcqA-3t6qA:
undetectable
5zcqJ-3t6qA:
undetectable
5zcqA-3t6qA:
19.07
5zcqJ-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 GLN A 282
GLU A 256
HIS A 309
ALA A 307
None
1.13A 6f6jC-3t6qA:
undetectable
6f6jD-3t6qA:
undetectable
6f6jC-3t6qA:
20.29
6f6jD-3t6qA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 PHE A  97
LEU A 121
ALA A 120
ASN A 111
None
0.95A 6f88A-3t6qA:
undetectable
6f88A-3t6qA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 6 PHE A  97
LEU A 121
ALA A 120
THR A 135
None
0.96A 6f88A-3t6qA:
undetectable
6f88A-3t6qA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 7 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.81A 6nmpA-3t6qA:
undetectable
6nmpJ-3t6qA:
undetectable
6nmpA-3t6qA:
19.07
6nmpJ-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3t6q CD180 ANTIGEN
(Mus
musculus)
4 / 5 ILE A 352
LEU A 377
THR A 348
LEU A 372
None
0.80A 6nmpN-3t6qA:
undetectable
6nmpW-3t6qA:
undetectable
6nmpN-3t6qA:
19.07
6nmpW-3t6qA:
7.06