SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 5 HIS A 238
LEU A 185
SER A 179
GLY A 183
 None
 1.13A 1a4lB-3t7bA:
undetectable		 1a4lB-3t7bA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 12 LEU A 167
ALA A 173
LEU A  37
LEU A   8
ALA A 164
 None
 0.94A 1ao8A-3t7bA:
undetectable		 1ao8A-3t7bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 12 LEU A 167
ALA A 173
LEU A  37
LEU A   8
ALA A 164
 None
 0.97A 1bzfA-3t7bA:
undetectable		 1bzfA-3t7bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 12 LEU A  13
ALA A  83
LEU A  87
ALA A  91
ILE A 143
 None
 1.06A 1fk6A-3t7bA:
undetectable		 1fk6A-3t7bA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 7 ILE A 255
THR A 253
MET A 195
MET A 213
 None
 1.27A 1kglA-3t7bA:
undetectable		 1kglA-3t7bA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		3 / 3 LEU A 185
LEU A 203
MET A 213
 None
 0.76A 1ya3B-3t7bA:
undetectable		 1ya3B-3t7bA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 9 LEU A   4
LEU A  37
ILE A  39
LEU A 178
ILE A 176
 None
 1.21A 2f78A-3t7bA:
undetectable		 2f78A-3t7bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 9 LEU A   4
LEU A  37
ILE A  39
LEU A 178
ILE A 176
 None
 1.24A 2f78B-3t7bA:
undetectable		 2f78B-3t7bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 9 LEU A   4
LEU A  37
ILE A  39
LEU A 178
ILE A 176
 None
 1.14A 2f7aB-3t7bA:
undetectable		 2f7aB-3t7bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 6 LEU A 221
ASN A 218
ILE A 209
ALA A 200
 None
 1.01A 2j5mA-3t7bA:
undetectable		 2j5mA-3t7bA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 6 VAL A 214
GLY A  63
ARG A  65
LEU A 118
 None
 1.07A 3bjwE-3t7bA:
undetectable		 3bjwE-3t7bA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 6 LEU A 167
LEU A 171
LEU A  37
PRO A 142
 None
 1.12A 3q1eA-3t7bA:
undetectable
3q1eC-3t7bA:
undetectable		 3q1eA-3t7bA:
17.37
3q1eC-3t7bA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 7 ILE A 147
ILE A  72
GLU A 152
VAL A 111
 None
 0.86A 3ua5B-3t7bA:
undetectable		 3ua5B-3t7bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		3 / 3 HIS A  41
GLY A 100
ILE A 143
 None
 0.60A 4k50A-3t7bA:
undetectable		 4k50A-3t7bA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		3 / 3 HIS A  41
GLY A 100
ILE A 143
 None
 0.60A 4k50I-3t7bA:
undetectable		 4k50I-3t7bA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 9 PRO A 230
VAL A 231
ALA A 224
GLY A 172
GLY A 228
 None
 1.21A 4mm5A-3t7bA:
undetectable		 4mm5A-3t7bA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 11 PRO A 230
VAL A 231
ALA A 224
SER A 226
GLY A 228
 None
 1.27A 4mmaA-3t7bA:
undetectable		 4mmaA-3t7bA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 9 PRO A 230
VAL A 231
ALA A 224
GLY A 172
GLY A 228
 None
 1.15A 4mmbA-3t7bA:
undetectable		 4mmbA-3t7bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 10 PRO A 230
VAL A 231
ALA A 224
GLY A 172
GLY A 228
 None
 1.24A 4mmdA-3t7bA:
undetectable		 4mmdA-3t7bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 12 SER A 146
LEU A 167
VAL A 132
LEU A  13
LEU A  79
 GLU  A 258 ( 4.0A)
None
None
None
None
 1.44A 4o8fB-3t7bA:
undetectable		 4o8fB-3t7bA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 8 ILE A   6
LYS A   7
ILE A 176
ALA A 234
 None
GLU  A 258 (-2.7A)
None
None
 0.93A 4ou1A-3t7bA:
undetectable		 4ou1A-3t7bA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 12 LEU A 178
TRP A 236
ILE A 184
LEU A 185
GLY A   9
 None
None
None
None
GLU  A 258 ( 4.0A)
 1.11A 5d4uA-3t7bA:
undetectable		 5d4uA-3t7bA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 12 LEU A 178
TRP A 236
ILE A 184
LEU A 185
GLY A   9
 None
None
None
None
GLU  A 258 ( 4.0A)
 1.13A 5d4uB-3t7bA:
undetectable		 5d4uB-3t7bA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 7 ILE A 255
THR A 253
MET A 195
MET A 213
 None
 1.19A 5ljcA-3t7bA:
undetectable		 5ljcA-3t7bA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		4 / 6 ILE A 255
THR A 253
MET A 195
MET A 213
 None
 1.22A 5ljeA-3t7bA:
undetectable		 5ljeA-3t7bA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 11 PRO A 243
LEU A 178
LEU A   4
ASP A 174
LYS A   0
 None
 1.46A 6dlzA-3t7bA:
undetectable
6dlzD-3t7bA:
undetectable		 6dlzA-3t7bA:
14.86
6dlzD-3t7bA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 9 GLY A 252
LEU A 178
LEU A   4
ASP A 174
LYS A   0
 None
 1.40A 6dm0A-3t7bA:
1.4
6dm0D-3t7bA:
1.8		 6dm0A-3t7bA:
14.86
6dm0D-3t7bA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3t7b ACETYLGLUTAMATE
KINASE
(Yersinia
pestis) 		5 / 11 PRO A 243
LEU A 178
LEU A   4
ASP A 174
LYS A   0
 None
 1.45A 6dm1A-3t7bA:
undetectable
6dm1D-3t7bA:
undetectable		 6dm1A-3t7bA:
14.86
6dm1D-3t7bA:
14.86